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Sigma Receptors: Their Role in Disease and as Therapeutic Targets

  • Book
  • © 2017

Overview

Editors:
  1. Sylvia B. Smith

    1. Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, USA

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  2. Tsung-Ping Su

    1. Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Very few books about Sigma receptors, yet the field regarding Sigma receptors has exploded
  • A comprehensive treatise on this unique protein
  • Of significant relevance to very severe diseases (blindness, ALS, AD, PK, pain, schizophrenia, HD)

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 964)

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Table of contents (20 chapters)

  1. Front Matter

    Pages i-xiii
    Download chapter PDF

  2. Introduction to Sigma Receptors: Their Role in Disease and as Therapeutic Targets

    • Sylvia B. Smith
    Pages 1-4

  3. Structural Perspectives on Sigma-1 Receptor Function

    • Assaf Alon, Hayden Schmidt, Sanduo Zheng, Andrew C. Kruse
    Pages 5-13

  4. A Review of the Human Sigma-1 Receptor Structure

    • Felipe Ossa, Jason R. Schnell, José Luis Ortega-Roldan
    Pages 15-29

  5. Fluorinated PET Tracers for Molecular Imaging of σ1 Receptors in the Central Nervous System

    • Frauke Weber, Peter Brust, Erik Laurini, Sabrina Pricl, Bernhard Wünsch
    Pages 31-48

  6. The Evolution of the Sigma-2 (σ2) Receptor from Obscure Binding Site to Bona Fide Therapeutic Target

    • Chenbo Zeng, Robert H. Mach
    Pages 49-61

  7. Sigma 1 Receptor and Ion Channel Dynamics in Cancer

    • Olivier Soriani, Raphaël Rapetti-Mauss
    Pages 63-77

  8. Sigma-1 Receptors Fine-Tune the Neuronal Networks

    • Shang-Yi Anne Tsai, Tsung-Ping Su
    Pages 79-83

  9. Pharmacological Modulation of the Sigma 1 Receptor and the Treatment of Pain

    • Manuel Merlos, Javier Burgueño, Enrique Portillo-Salido, Carlos Ramón Plata-Salamán, José Miguel Vela
    Pages 85-107

  10. Sigma-1 Receptor Antagonists: A New Class of Neuromodulatory Analgesics

    • Cristina Sánchez-Fernández, José Manuel Entrena, José Manuel Baeyens, Enrique José Cobos
    Pages 109-132

  11. Sigma-1 Receptors and Neurodegenerative Diseases: Towards a Hypothesis of Sigma-1 Receptors as Amplifiers of Neurodegeneration and Neuroprotection

    • Linda Nguyen, Brandon P. Lucke-Wold, Shona Mookerjee, Nidhi Kaushal, Rae R. Matsumoto
    Pages 133-152

  12. Sigma-1 Receptor Agonists and Their Clinical Implications in Neuropsychiatric Disorders

    • Yakup Albayrak, Kenji Hashimoto
    Pages 153-161

  13. Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease

    • Yu Cai, Lu Yang, Fang Niu, Ke Liao, Shilpa Buch
    Pages 163-175

  14. Sigma Receptors and Substance Use Disorders

    • Valentina Sabino, Callum Hicks, Pietro Cottone
    Pages 177-199

  15. Stimulation of the Sigma-1 Receptor and the Effects on Neurogenesis and Depressive Behaviors in Mice

    • Kohji Fukunaga, Shigeki Moriguchi
    Pages 201-211

  16. Role of σ1 Receptors in Learning and Memory and Alzheimer’s Disease-Type Dementia

    • Tangui Maurice, Nino Goguadze
    Pages 213-233

  17. Sigma-1 Receptor in Motoneuron Disease

    • Renzo Mancuso, Xavier Navarro
    Pages 235-254

  18. The Sigma-1 Receptor–A Therapeutic Target for the Treatment of ALS?

    • Timur A. Mavlyutov, Erin M. Baker, Tasher M. Losenegger, Jaimie R. Kim, Brian Torres, Miles L. Epstein et al.
    Pages 255-265

  19. The Role of Sigma1R in Mammalian Retina

    • Jing Wang, Xuezhi Cui, Penny Roon, Alan Saul, Sylvia B. Smith
    Pages 267-284

  20. Peeking into Sigma-1 Receptor Functions Through the Retina

    • Timur A. Mavlyutov, Lian-Wang Guo
    Pages 285-297
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Keywords

About this book

Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types.  It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors.  Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.

Editors and Affiliations

  • Departments of Cellular Biology and Anatomy and Ophthalmology and the James and Jean Culver Vision Discovery Institute, Medical College of Georgia at Augusta University, Augusta, USA

    Sylvia B. Smith

  • Cellular Pathobiology Section, Integrative Neuroscience Research Branch, Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, US Department of Health and Human Services, Baltimore, USA

    Tsung-Ping Su

Bibliographic Information

  • Book Title: Sigma Receptors: Their Role in Disease and as Therapeutic Targets

  • Editors: Sylvia B. Smith, Tsung-Ping Su

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-50174-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing AG (outside the USA) 2017

  • Hardcover ISBN: 978-3-319-50172-7Published: 27 March 2017

  • Softcover ISBN: 978-3-319-84335-3Published: 13 June 2018

  • eBook ISBN: 978-3-319-50174-1Published: 16 March 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XIII, 312

  • Number of Illustrations: 14 b/w illustrations, 45 illustrations in colour

  • Topics: Biomedicine general, Protein Science, Receptors

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