Overview
- Presents a unique compendium on sumoylation topics
- Provides authoritative contributions from leading experts in the field of sumoylation
- Expands on a previous edition with 6 new chapters
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 963)
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Table of contents (22 chapters)
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Front Matter
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Molecular Functions
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Front Matter
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Cell Growth Regulation
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Front Matter
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Diseases
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Front Matter
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Keywords
About this book
This is the second edition of a very well received book that details how the sumoylation system functions and how it modulates numerous cellular activities. SUMO is a post-translational modifier in the ubiquitin super-family that has gained recognition over the last twenty years as an essential and prevalent regulatory molecule.
Individual chapters explore the biochemistry, molecular biology, and cell biology of the sumoylation system and its substrate proteins.
The book is divided into three themed parts: Molecular Functions (I), Cell Growth Regulation (II), and Diseases (III). Parts I and II focus on the contribution of sumoylation to cellular activities in both the nuclear and cytoplasmic compartments. The nuclear activities covered include nucleic acid metabolism (both RNA and DNA), chromosome structure and replication, and nucleocytoplasmic transport. Cytoplasmic processes presented include regulation of membrane ion channels, general metabolism, and apoptotic signalling. Topics in Part III include the role of sumoylation in developmental abnormalities (craniofacial and cardiovascular), diabetes, neurodegenerative diseases, cancer, and infections with viruses and bacteria.
Each of the corresponding chapter authors is an active researcher who has made significant contributions to understanding sumoylation. This second edition provides updates and revisions to most of the original chapters plus adds six new chapters to address important developing areas of sumoylation research.
This volume is intended for a scientific audience from undergraduates to independent researchers. The content will serve as both a solid introduction for the novice reader and an in depth treatment for the advanced scholar.
Editors and Affiliations
Bibliographic Information
Book Title: SUMO Regulation of Cellular Processes
Editors: Van G. Wilson
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-50044-7
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-50043-0Published: 24 February 2017
Softcover ISBN: 978-3-319-84304-9Published: 20 June 2018
eBook ISBN: 978-3-319-50044-7Published: 13 February 2017
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 2
Number of Pages: VIII, 415
Number of Illustrations: 15 b/w illustrations, 26 illustrations in colour
Topics: Biomedicine general, Protein Science, Cell Biology, Posttranslational Modification