Malignant Brain Tumors

1. Front Matter

   Pages i-xi

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2. Molecular and Clinical Characterization of Gliomas

   1. Front Matter

      Pages 1-1

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   2. Use of Advanced Neuroimaging (fMRI, DTI/Tractography) in the Treatment of Malignant Gliomas

      • Nicole M. Petrovich Brennan, Andrei I. Holodny

      Pages 3-13

   3. Molecular Neuropathology and the Ontogeny of Malignant Gliomas

      • Anita Huttner

      Pages 15-29

   4. Personalized Medicine Through Advanced Genomics

      • Mark W. Youngblood, E. Zeynep Erson-Omay, Murat Günel

      Pages 31-48

3. Surgery: Maximizing the Extent of Tumor Resection

   1. Front Matter

      Pages 49-49

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   2. The Usefulness of Stereotactic Neuronavigation Along with Intraoperative Imaging in Malignant Brain Tumor Surgery

      • Gregory Kuzmik, Anne Long, S. Bulent Omay, Jennifer Moliterno Günel

      Pages 51-62

   3. Mapping the Brain for Primary Brain Tumor Surgery

      • Emmanuel Mandonnet, Hugues Duffau

      Pages 63-79

   4. Fluorescence-Guided Resection of Malignant Gliomas

      • Walter Stummer

      Pages 81-101

   5. The Role of Laser-Induced Thermal Therapy in the Management of Malignant Gliomas

      • Elena Fomchenko, Veronica L. S. Chiang

      Pages 103-119

4. Adjuvant Therapies

   1. Front Matter

      Pages 121-121

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   2. Current Standard Treatment Options for Malignant Glioma

      • Kevin P. Becker, Joachim M. Baehring

      Pages 123-131

   3. Targeting Aberrant Signaling Pathways

      • Jacob Mandel, Santosh Kesari

      Pages 133-150

   4. Targeted Therapy of IDH1-Mutated Tumors

      • Owen Clark, Christian Grommes

      Pages 151-161

   5. Antiangiogenic Therapy for Malignant Gliomas

      • Nancy Wang, Jonas Kloepper, Rakesh K. Jain, Tracy T. Batchelor

      Pages 163-175

   6. Immunotherapy for High-Grade Gliomas

      • Teilo H. Schaller, John H. Sampson

      Pages 177-192

   7. Novel Delivery Strategies

      • David S. Hersh, Aniket S. Wadajkar, Graeme F. Woodworth

      Pages 193-216

   8. Radiation Therapy for Malignant Gliomas: Current Options

      • Laura E. G. Warren, Marc R. Bussiére, Helen A. Shih

      Pages 217-231

   9. Glioma Radiosensitizers: Exciting New Developments and Directions

      • Christopher D. Corso, Ranjit S. Bindra

      Pages 233-240

5. Tumor-Specific Approach

   1. Front Matter

      Pages 241-241

      PDF

This text addresses all aspects of patient evaluation and care. This includes new findings in imaging that provide a better understanding of the extent of the lesion as well as its relationship with critical neuroanatomic function. The evolution of intraoperative imaging, functional brain mapping,and technology to identify tumor from brain is covered. This has significantly improved the ability of surgeons to more safely and aggressively remove tumors.More importantly, a better understanding of tumor biology and genomics has created an opportunity to significantly revise tumor classification and better select optimal therapy for individual patients. The text covers novel and innovative treatment options including immunotherapy, tumor vaccines, antiangiogenic agents,and personalized cancer treatment.  In addition, novel agent delivery techniques are covered to offer the potential for increasing the effectiveness of treatment by delivering active agents directly where they are needed most.


Malignant Brain Tumors: State-of-the-Art Treatment provides a comprehensive overview of treatment for malignant gliomas, and will prove useful by updating physicians on new therapeutic paradigms and what is on the horizon for the near future. This text will be informative for surgeons, oncologists, neurologists, residents and students who treat these patients,as well as those who are training for a career in managing patients with these challenging tumors.
 

• Biology of Gliomas
• Neuro-Imaging
• Intraoperative Imaging
• Fluorescence-guided resection
• Antiangiogenic Therapy
• Oligodendroglioma
• Glioblastoma multiforme
• surgical oncology

“This textbook analyzes the dismal prognosis and very limited efficacy for single or multi agent therapy of Glioblastomas GBMs. … I recommend this book to neurosurgeons and oncologists” (Joseph Grenier, Amazon.de, May, 2018)

“This succinct book is designed as a comprehensive, yet concise update on the contemporary treatment of gliomas. … The audience includes neurosurgeons, neurologists, oncologists, and all practitioners with routine exposure to gliomas. … This is a satisfactory update on the contemporary biology and treatment for neuro-oncology’s enduring foe: gliomas. … The book provides a succinct, effective research update for clinicians wishing to familiarize themselves with advances in the field over the last decade.” (Darian Ross Esfahani, Doody’s Book Reviews, April, 2017)

• Neurosurgical Oncology, Yale University School of Medicine Neurosurgical Oncology, New Haven, USA

  Jennifer Moliterno Gunel

• Yale University School of Medicine, New Haven, USA

  Joseph M Piepmeier

• Yale School of Medicine, New Haven, USA

  Joachim M. Baehring

Joseph M Piepmeier, MD
Nixdorff-German Professor of Neurosurgery
Department of Neurosurgery
Yale University School of Medicine
New Haven, Connecticut
USA


Jennifer Moliterno Gunel, MD
Assistant Professor, Department of Neurosurgery
Section of Neurosurgical Oncology
Yale University School of Medicine
New Haven, Connecticut
USA




Joachim M. Baehring, MD, DSc.
Department of Neurology and Neurosurgery
Yale University School of Medicine
New Haven, Connecticut
USA

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