Overview
- Editors:
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Gael Cristofari
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Institute for Research on Cancer and Aging of Nice (IRCAN), French National Institute of Health and Medical Research (INSERM), Centre National de la Recherche Scientifique (CNRS), Faculty of Medicine, University of Nice-Sophia Antipolis (UNS), Université Côte d’Azur (UCA), Nice, France
- Authored by leading experts in the field
- The first book to explore not only insertion-based effects and their related consequences on germline and somatic genome dynamics, but also the role and impact of retrotransposons sequences in it's broader context
- Includes sections on lncRNA, neuronal disorders, and exaptation
- Includes supplementary material: sn.pub/extras
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Table of contents (13 chapters)
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- Simon J. Newkirk, Wenfeng An
Pages 29-61
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- Tara T. Doucet-O’Hare, Haig H. Kazazian Jr.
Pages 63-93
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- Marie-Jeanne H. C. Kempen, Gabriela O. Bodea, Geoffrey J. Faulkner
Pages 107-125
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- Angela Macia, Leon Tejwani, Pinar Mesci, Alysson Muotri, Jose L. Garcia-Perez
Pages 127-156
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- Catherine M. Ade, Geraldine Servant, Maria E. Morales, Astrid M. Roy-Engel
Pages 157-194
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- Zhaohui Su, Guillaume Bourque
Pages 195-213
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- Caroline Toudic, Xavier Elisseeff, Adjimon Gatien Lokossou, Benoit Barbeau
Pages 215-238
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- Maria E. Morales, Geraldine Servant, Catherine M. Ade, Prescott Deininger
Pages 239-257
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- Cristina Tufarelli, Richard M. Badge
Pages 259-273
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- Jill A. Kreiling, Brian C. Jones, Jason G. Wood, Marco De Cecco, Steven W. Criscione, Nicola Neretti et al.
Pages 297-321
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Back Matter
Pages 323-330
About this book
This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.
Editors and Affiliations
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Institute for Research on Cancer and Aging of Nice (IRCAN), French National Institute of Health and Medical Research (INSERM), Centre National de la Recherche Scientifique (CNRS), Faculty of Medicine, University of Nice-Sophia Antipolis (UNS), Université Côte d’Azur (UCA), Nice, France
Gael Cristofari
About the editor
Gael Cristofari is a biomedical expert in Molecular Biology & Genetics and Biology & Biochemistry at IRCAN, in Nice, France.
