Human Retrotransposons in Health and Disease

1. Front Matter

   Pages i-x

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2. Retrotransposons and the Mammalian Germline

   • Ian R. Adams

   Pages 1-28

3. L1 Regulation in Mouse and Human Germ Cells

   • Simon J. Newkirk, Wenfeng An

   Pages 29-61

4. Retrotransposon Contribution to Genomic Plasticity

   • Tara T. Doucet-O’Hare, Haig H. Kazazian Jr.

   Pages 63-93

5. The Mobilisation of Processed Transcripts in Germline and Somatic Tissues

   • Adam D. Ewing

   Pages 95-106

6. Neuronal Genome Plasticity: Retrotransposons, Environment and Disease

   • Marie-Jeanne H. C. Kempen, Gabriela O. Bodea, Geoffrey J. Faulkner

   Pages 107-125

7. Activity of Retrotransposons in Stem Cells and Differentiated Cells

   • Angela Macia, Leon Tejwani, Pinar Mesci, Alysson Muotri, Jose L. Garcia-Perez

   Pages 127-156

8. Environment, Cellular Signaling, and L1 Activity

   • Catherine M. Ade, Geraldine Servant, Maria E. Morales, Astrid M. Roy-Engel

   Pages 157-194

9. Retrotransposon-Derived Regulatory Regions and Transcripts in Stemness

   • Zhaohui Su, Guillaume Bourque

   Pages 195-213

10. Roles of Endogenous Retrovirus-Encoded Syncytins in Human Placentation

    • Caroline Toudic, Xavier Elisseeff, Adjimon Gatien Lokossou, Benoit Barbeau

    Pages 215-238

11. Alu-Alu Recombinations in Genetic Diseases

    • Maria E. Morales, Geraldine Servant, Catherine M. Ade, Prescott Deininger

    Pages 239-257

12. Retrotransposon-Driven Transcription and Cancer

    • Cristina Tufarelli, Richard M. Badge

    Pages 259-273

13. LINE-1 Retrotransposons as Neoplastic Biomarkers

    • Nemanja Rodic

    Pages 275-295

14. Contribution of Retrotransposable Elements to Aging

    • Jill A. Kreiling, Brian C. Jones, Jason G. Wood, Marco De Cecco, Steven W. Criscione, Nicola Neretti et al.

    Pages 297-321

15. Back Matter

    Pages 323-330

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This unique book explores the role of retrotransposons in human health and disease. The ability of retrotransposons to affect the structure of human genes is recognized since the late 80’s. However, the advances of deep-sequencing technologies have shed new light on the extent of retrotransposon-mediated genome variations. These progresses have also led to the discovery that retrotransposon activity is not restricted to the germline - resulting in inheritable genetic variations - but can also mobilize in somatic tissues, such as embryonic stem cells, neuronal progenitor cells, or in many cancers. This book covers topics related to the effects of retrotransposon insertions, and their consequences on germline and somatic genome dynamics, but also discuss the role and impact of retrotransposons sequences in a broader context, including a number of novel topics that emerged recently (long non-coding RNA, neuronal disorders, exaptation) with unexpected connections between retrotransposons, stem cell maintenance, placentation, circadian cycles or aging.

• Epigenetics
• Genome
• Germline
• L1
• lncRNA
• Mutagenesis

• Institute for Research on Cancer and Aging of Nice (IRCAN), French National Institute of Health and Medical Research (INSERM), Centre National de la Recherche Scientifique (CNRS), Faculty of Medicine, University of Nice-Sophia Antipolis (UNS), Université Côte d’Azur (UCA), Nice, France

  Gael Cristofari

Gael Cristofari is a biomedical expert in Molecular Biology & Genetics and Biology & Biochemistry at IRCAN, in Nice, France.

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