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Metabolomics: From Fundamentals to Clinical Applications

  • Book
  • © 2017

Overview

Editors:
  1. Alessandra Sussulini

    1. University of Campinas (UNICAMP) Institute of Chemistry Laboratory of Bioanalytics and Integrated Omics (LaBIOmics), Campinas, Brazil

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  • This book consists in providing a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine
  • The first book to cover metabolomics clinical applications also emphasizing analytical and statistical features
  • Written by experts in the field

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 965)

Part of the book sub series: Proteomics, Metabolomics, Interactomics and Systems Biology (PMISB)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
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  2. Fundamentals and Analytical Methodologies in Metabolomics

    1. Front Matter

      Pages 1-1
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    2. Metabolomics: Definitions and Significance in Systems Biology

      • Aline Klassen, Andréa Tedesco Faccio, Gisele André Baptista Canuto, Pedro Luis Rocha da Cruz, Henrique Caracho Ribeiro, Marina Franco Maggi Tavares et al.
      Pages 3-17

    3. Collection and Preparation of Clinical Samples for Metabolomics

      • Andrew J. Chetwynd, Warwick B. Dunn, Giovanny Rodriguez-Blanco
      Pages 19-44

    4. Nuclear Magnetic Resonance Strategies for Metabolic Analysis

      • Clement Heude, Jay Nath, John Bosco Carrigan, Christian Ludwig
      Pages 45-76

    5. Metabolomic Strategies Involving Mass Spectrometry Combined with Liquid and Gas Chromatography

      • Aline Soriano Lopes, Elisa Castañeda Santa Cruz, Alessandra Sussulini, Aline Klassen
      Pages 77-98

    6. Strategies Involving Mass Spectrometry Combined with Capillary Electrophoresis in Metabolomics

      • Karina Trevisan Rodrigues, Zuzana Cieslarová, Marina Franco Maggi Tavares, Ana Valéria Colnaghi Simionato
      Pages 99-141

  3. Statistical Analysis and Data Interpretation

    1. Front Matter

      Pages 143-143
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    2. Preprocessing and Pretreatment of Metabolomics Data for Statistical Analysis

      • Ibrahim Karaman
      Pages 145-161

    3. Chemometrics Methods and Strategies in Metabolomics

      • Rui Climaco Pinto
      Pages 163-190

    4. Computational Strategies for Biological Interpretation of Metabolomics Data

      • Jianguo Xia
      Pages 191-206

  4. Applications and Future Trends of Metabolomics in Clinical Cases

    1. Front Matter

      Pages 207-207
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    2. Applications of Metabolomics in Cancer Studies

      • Emily Grace Armitage, Michal Ciborowski
      Pages 209-234

    3. Chronic Diseases and Lifestyle Biomarkers Identification by Metabolomics

      • Annalaura Mastrangelo, Coral Barbas
      Pages 235-263

    4. Lipidomics, Biomarkers, and Schizophrenia: A Current Perspective

      • Sumit Sethi, Mirian A. F. Hayashi, Banny S. Barbosa, João G. M. Pontes, Ljubica Tasic, Elisa Brietzke
      Pages 265-290

    5. Spatial Metabolite Profiling by Matrix-Assisted Laser Desorption Ionization Mass Spectrometry Imaging

      • Berin A. Boughton, Brett Hamilton
      Pages 291-321

    6. Single-Cell Metabolomics

      • Samy Emara, Sara Amer, Ahmed Ali, Yasmine Abouleila, April Oga, Tsutomu Masujima
      Pages 323-343

  5. Erratum to: Chapters 1 and 11 of Metabolomics: From Fundamentals to Clinical Applications

    • Alessandra Sussulini
    Pages E1-E2

  6. Back Matter

    Pages 345-350
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Keywords

About this book

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented.

For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions. 

Editors and Affiliations

  • University of Campinas (UNICAMP) Institute of Chemistry Laboratory of Bioanalytics and Integrated Omics (LaBIOmics), Campinas, Brazil

    Alessandra Sussulini

About the editor

Alessandra Sussulini received her PhD in Analytical Chemistry from the University of Campinas, Brazil. Since 2014, she has been an Assistant Professor at the same university. Previously, she was a postdoctoral fellow from the Alexander von Humboldt Foundation at the BrainMet (Bioimaging of Metals in Brain and Metallomics) laboratory at the Central Division of Analytical Chemistry, Forschungszentrum Jülich, Germany. Her current research activities are focused on the application of imaging mass spectrometry (LA-ICP-IMS, MALDI-IMS and DESI-IMS), proteomics and metabolomics strategies to investigate clinical and toxicological biomarkers.

Bibliographic Information

  • Book Title: Metabolomics: From Fundamentals to Clinical Applications

  • Editors: Alessandra Sussulini

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-47656-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2017

  • Hardcover ISBN: 978-3-319-47655-1Published: 02 February 2017

  • Softcover ISBN: 978-3-319-83792-5Published: 09 June 2018

  • eBook ISBN: 978-3-319-47656-8Published: 28 January 2017

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 350

  • Number of Illustrations: 2 b/w illustrations, 54 illustrations in colour

  • Topics: Metabolomics, Gene Therapy, Gene Function

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