Authors:
- Explores the biology of interleukin 12 and its potential in cancer therapy
- Discusses antitumor effects identified in preclinical studies and clinical trials in cancer immunotherapy
- Is particularly relevant for scientists working in the pharmaceutical industry and in clinical oncology
- Includes supplementary material: sn.pub/extras
Part of the book series: SpringerBriefs in Immunology (BRIEFSIMMUN)
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Table of contents (3 chapters)
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Front Matter
About this book
This book discusses the immunotherapeutic potential of Interleukin 12 in the context of clinical oncology, as well as antitumor effects confirmed in preclinical studies and clinical trials in cancer immunotherapy. Due to its ability to activate both innate (NK cells) and adaptive (cytotoxic T lymphocytes) immunities, Interleukin 12 (IL-12) has been regarded as a promising candidate for tumor immunotherapy. However, despite the encouraging results in animal models, only very modest antitumor effects have been confirmed in early clinical trials. Recently, several clinical studies have been initiated in which IL-12 was applied as an adjuvant in cancer vaccines, in gene therapy including locoregional injections of IL-12 plasmid, and in the form of tumor-targeting immunocytokines (IL-12 fused to monoclonal antibodies).
Authors and Affiliations
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Department of Immunology, Centre for Biostructure Research, Medical University of Warsaw, Warsaw, Poland
Witold Lasek
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Department of Immunology, Medical University of Warsaw, Warsaw, Poland
Radoslaw Zagozdzon
Bibliographic Information
Book Title: Interleukin 12: Antitumor Activity and Immunotherapeutic Potential in Oncology
Authors: Witold Lasek, Radoslaw Zagozdzon
Series Title: SpringerBriefs in Immunology
DOI: https://doi.org/10.1007/978-3-319-46906-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Author(s) 2016
Softcover ISBN: 978-3-319-46905-8Published: 06 October 2016
eBook ISBN: 978-3-319-46906-5Published: 23 September 2016
Series ISSN: 2194-2773
Series E-ISSN: 2194-2781
Edition Number: 1
Number of Pages: VII, 75
Number of Illustrations: 6 b/w illustrations
Topics: Immunology, Cancer Research, Cytokines and Growth Factors, Oncology, Cell Biology