Editors:
- Offers cutting-edge information on the development of antibody drug conjugates and recombinant immunotoxins
- Explores related basic biological and chemical technologies and promotes new developments toward clinical applications
- Primarily aimed at postgraduate students, researchers and clinicians
Part of the book series: Milestones in Drug Therapy (MDT)
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Table of contents (8 chapters)
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Front Matter
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Back Matter
About this book
This book describes the newest developments in antibody drug conjugates and immunotoxins, paving their way to clinical application. Lessons learned from the current state of the art are used to further improve our understanding of their mechanisms of action and off target activities.
The book introduces scientists to all of the prerequisites that must be properly addressed, including identification of the right target, specific traits of target binding antibodies, proper selection of the toxic payload, internalization induced by binding, and next generation conjugation and linker technologies. These knowledge-based, revolutionary new drug principles will form the cornerstone of the future standard of care and will lead to major advances in application, as well as improved quality of life and patient survival rates. This book will be of interest to biotech companies and researchers working in the fields of immunology, pharmacology, and oncology.
Editors and Affiliations
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NBE-Therapeutics Ltd., Basel, Switzerland
Ulf Grawunder
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Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa
Stefan Barth
Bibliographic Information
Book Title: Next Generation Antibody Drug Conjugates (ADCs) and Immunotoxins
Editors: Ulf Grawunder, Stefan Barth
Series Title: Milestones in Drug Therapy
DOI: https://doi.org/10.1007/978-3-319-46877-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing AG 2017
Hardcover ISBN: 978-3-319-46875-4Published: 18 April 2017
Softcover ISBN: 978-3-319-83609-6Published: 18 July 2018
eBook ISBN: 978-3-319-46877-8Published: 07 April 2017
Series ISSN: 2296-6056
Series E-ISSN: 2296-6064
Edition Number: 1
Number of Pages: XI, 181
Number of Illustrations: 18 b/w illustrations, 39 illustrations in colour
Topics: Pharmacology/Toxicology, Antibodies, Pharmacotherapy, Cancer Research, Oncology