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  • © 2016

The Pathology of Cardiac Transplantation

A clinical and pathological perspective

  • Offers a comparative clinical–pathological diagnostic approach to each phase of the cardiac transplant process

  • Includes detailed, up-to-date pathological protocols

  • Features more than 150 color photos and illustrative cases to guide diagnosis

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Table of contents (25 chapters)

  1. Front Matter

    Pages i-xx
  2. Introduction

    1. Front Matter

      Pages 1-1
    2. Cardiac Transplantation and the Contribution of Pathology

      • Margaret Burke, Luciano Potena
      Pages 3-10
  3. Prior to Cardiac Transplantation

    1. Front Matter

      Pages 11-11
    2. Advanced End-Stage Heart Failure: Epidemiology and Management

      • John Parissis, Spyridon Katsanos, Sergei Pepoyan, Gerasimos Filippatos
      Pages 13-20
    3. Mechanical Circulatory Support in End-Stage Heart Failure: Bridge to Transplantation and Destination Therapy

      • Alexander Stepanenko, Evgenij Potapov, Volkmar Falk, Thomas Krabatsch
      Pages 21-32
    4. Clinical Indications for Heart Transplantation

      • Francesco Tona, Carlo Dal Lin
      Pages 33-40
    5. Pathologies Encountered in Explanted Native Hearts

      • Ornella Leone, Annalisa Angelini, Marny Fedrigo, Aryan Vink, Allard van der Wal
      Pages 41-99
  4. Heart Donation and Peritransplant Pathologies

    1. Front Matter

      Pages 113-113
    2. Donor Selection Criteria: Clinical and Pathological Insights

      • Ornella Leone, Luciano Potena, Alberto Foà, Andreas Zuckermann
      Pages 115-135
    3. Donor Organ Harvesting and Preservation

      • Jonida Bejko, Giuseppe Feltrin, Annalisa Angelini, Gino Gerosa
      Pages 137-145
    4. Perioperative Myocardial Damage to the Graft

      • Annalisa Angelini, Marny Fedrigo
      Pages 147-152
  5. Post-cardiac Transplantation: The Multiple Faces of Rejection

    1. Front Matter

      Pages 153-153
    2. Graft Failure/Dysfunction: Clinical Issues and Role of Endomyocardial Biopsy

      • Luciano Potena, Valentina Manfredini, Ornella Leone
      Pages 155-169
    3. Clinical Management of Transplant Recipients

      • Marco Masetti, Francesco Grigioni
      Pages 171-184
    4. Practical Immunology for Pathologists

      • John D. Smith, Marlene L. Rose
      Pages 185-198
    5. Pathology of Acute Cellular Rejection

      • Desley A. H. Neil, Alexandra J. Rice
      Pages 199-217
    6. Pathology of Antibody-Mediated Rejection

      • Samuel Rotman, Dylan V. Miller, Claire Toquet, Gerald J. Berry
      Pages 219-242
    7. “Mixed” Rejection in Heart Transplantation

      • Dylan V. Miller, Abdallah G. Kfoury
      Pages 243-250

About this book

This is the first book to focus entirely on the role of pathology in cardiac transplantation, linked to the clinical perspective through clinical–pathological correlation, multidisciplinary team working, and collaborative research. It provides a scientific framework with up-to-date pathological protocols and classification schemes and guides the reader through the chronological phases of the transplant process in a step-by-step approach. Topics include end-stage heart failure with pathologies encountered in the native heart, current issues surrounding donor selection, the multiple faces of rejection pathology correlated with clinical management and immunology, other post-transplant complications, details of pediatric and combined heart/other organ transplantation, and a useful practical appendix. Many high-quality images and illustrative cases are presented, along with learning points and ample references.

Transplantation medicine today is continuously changing as collaborative research into novel diagnostic techniques and immunosuppressive therapies translates into improved recipient management and survival. This book is aimed at practicing transplant pathologists and specialist trainees. It will also appeal to general pathologists and to physicians and surgeons involved in cardiac transplantation who need to understand the role of pathology in the clinical management of transplant recipients.

Editors and Affiliations

  • Cardiovascular and Cardiac Transplant Pathology Program Department of Pathology, Sant’Orsola-Malpighi University Hospital, Bologna, Italy

    Ornella Leone

  • Pathology of Cardiac Transplantation and Regenerative Medicine Unit Department of Cardiac Thoracic and Vascular Sciences, University of Padua, Padua, Italy

    Annalisa Angelini

  • Department of Pathology, Hôpital Européen Georges Pompidou, Paris, France

    Patrick Bruneval

  • Heart Failure and Heart Transplant Program, Cardiology Unit, Sant’Orsola-Malpighi University Hospital, Bologna, Italy

    Luciano Potena

About the editors

Annalisa Angelini, MD, is Associate Professor in Pathological Anatomy at University of Padua Medical School, Padua, Italy and Chief of the Heart Transplant Unit at Azienda Ospedaliera-Università Padua. Dr. Angelini became a Fellow of the European Society of Cardiology in 2004. She has served on a number of national and international committees, including as a Member of the Science Council, European Society of Cardiology (2004-6), Chair of the Working Group on Cardiovascular Morphology and Pathology, Association of European Paediatric Cardiologists (2007-present), and Chair of the ISHLT Council of Pathology and Basic Sciences (2009-10). She is a member of the editorial boards for the Journal of Heart and Lung Transplantation and Cardiogenesis and has published almost 170 papers in peer-reviewed journals.

Patrick Bruneval, MD, is Professor of Pathology, Université Paris Descartes, Paris, France, and Head of the Department of Pathology, Hôpital Européen Georges Pompidou, Paris. Dr. Bruneval has served as President of the Association for European Cardiovascular Pathology (2010-2) and Chair of the Pathology Council of the International Society for Heart and Lung Transplantation (2012-3). His research activities in the Paris-Centre de Recherche Cardiovasculaire (INSERM U970) have focused on the pathology of cardiac rejection (especially antibody-mediated rejection), renal fibrosis/inflammation, and cardiac cell therapy, and he has published very extensively on these and other topics.

 

Ornella Leone, MD, is Head of the Cardiovascular and Cardiac Transplant Pathology Unit at Sant’Orsola-Malpighi University Hospital, Bologna, Italy. From 2010 to 2013, Dr. Leone was President of the Italian Association for Cardiovascular Pathology. She has also served the Society of Cardiology as Coordinator of the Council of Directors for the Cardiovascular Anatomy and Pathology Group (2006-8) and Member of the Council of Directors of the Myocardial Disease Group (2012-4). Dr. Leone is a Founding Member of the Cardiovascular Anatomy and Pathology Group in the Italian Society of Cardiology and the Cardiovascular Pathology Group in the Italian Society of Pathology. She is a frequently invited speaker at national and international meetings and is the author of 93 journal articles, mostly in peer-reviewed journals.

 

Bibliographic Information

  • Book Title: The Pathology of Cardiac Transplantation

  • Book Subtitle: A clinical and pathological perspective

  • Editors: Ornella Leone, Annalisa Angelini, Patrick Bruneval, Luciano Potena

  • DOI: https://doi.org/10.1007/978-3-319-46386-5

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-46384-1Published: 13 February 2017

  • Softcover ISBN: 978-3-319-83507-5Published: 21 July 2018

  • eBook ISBN: 978-3-319-46386-5Published: 20 January 2017

  • Edition Number: 1

  • Number of Pages: XX, 450

  • Number of Illustrations: 11 b/w illustrations, 209 illustrations in colour

  • Topics: Pathology, Cardiology, Cardiac Surgery, Immunology

Buy it now

Buying options

eBook USD 109.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access