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The Immune Response to Implanted Materials and Devices

The Impact of the Immune System on the Success of an Implant

  • Book
  • © 2017

Overview

Editors:
  1. Bruna Corradetti

    1. Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy

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  • Explores the detrimental and beneficial effects of immune cells' activation in response to implants

  • Highlights the possibilities of biomimicry in modulating immune reactions

  • Describes the latest approaches to the activation of cellular immunity

  • Discusses regulatory challenges, translational considerations and literature case studies pertinent to the immunological safety of nanotechnology-based devices

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xviii
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  2. Host Response to Implanted Materials and Devices: An Overview

    • Michelle E. Scarritt, Ricardo Londono, Stephen F. Badylak
    Pages 1-14

  3. Implications of the Acute and Chronic Inflammatory Response and the Foreign Body Reaction to the Immune Response of Implanted Biomaterials

    • James M. Anderson, Sirui Jiang
    Pages 15-36

  4. Macrophages: The Bad, the Ugly, and the Good in the Inflammatory Response to Biomaterials

    • Marta Scatena, Karen V. Eaton, Melissa F. Jackson, Susan A. Lund, Cecilia M. Giachelli
    Pages 37-62

  5. Understanding Nanoparticle Immunotoxicity to Develop Safe Medical Devices

    • Marina A. Dobrovolskaia
    Pages 63-80

  6. Host Response to Synthetic Versus Natural Biomaterials

    • Kishor Sarkar, Yingfei Xue, Shilpa Sant
    Pages 81-105

  7. Convergence of Osteoimmunology and Immunomodulation for the Development and Assessment of Bone Biomaterials

    • Zetao Chen, Chengtie Wu, Yin Xiao
    Pages 107-124

  8. Modulation of Innate Immune Cells to Create Transplant Tolerance

    • Yue Zhao, Peixiang Lan, Xian C. Li
    Pages 125-150

  9. Inflammatory Cytokine Response to Titanium Surface Chemistry and Topography

    • Stephen M. Hamlet, Saso Ivanovski
    Pages 151-167

  10. The Biomechanical Environment and Impact on Tissue Fibrosis

    • Wayne Carver, Amanda M. Esch, Vennece Fowlkes, Edie C. Goldsmith
    Pages 169-188

  11. Advancing Islet Transplantation: From Donor to Engraftment

    • Omaima M. Sabek
    Pages 189-211

  12. Targeted Modulation of Macrophage Functionality by Nanotheranostics in Inflammatory Liver Disease and Cancer

    • Matthias Bartneck, Frank Tacke
    Pages 213-222

  13. T-Cell Mediated Immunomodulation and Transplant Optimization

    • Sandra Grass, Sara Khalid Al-Ageel, Martin Hildebrandt
    Pages 223-235

  14. Back Matter

    Pages 237-241
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Keywords

About this book

This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeutic outcome (healing, tissue restoration). Current cutting-edge approaches in tissue engineering, regenerative medicine, and nanomedicine offer the latest insights into the role immunomodulation in improving tolerance during tissue transplant in the treatment of orthopaedic, pancreatic, and hepatic diseases. "Immune Response to Implanted Materials and Devices" is intended for an audience of graduate students and professional researchers in both academia and industry interested in the development of smart strategies, which are able to exploit the self-healing properties of the body and achieve functional tissue restoration.

Editors and Affiliations

  • Department of Life and Environmental Sciences, Marche Polytechnic University, Ancona, Italy

    Bruna Corradetti

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