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Pancreatic Islet Biology

  • Book
  • © 2016

Overview

Editors:
  1. Anandwardhan A. Hardikar

    1. NHMRC Clinical Trials Centre Diabetes and Islet-biology Group, The University of Sydney Faculty of Medicine, Sydney, Australia

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  • Discusses the development of insulin-producing cells, the biggest research focus of stem cell biologists seeking a cure for diabetes
  • Explores key aspects of islet biology ranging from embryonic development and stem cell differentiation to clinical studies in islet transplantation
  • Provides worldwide expertise and an international perspective on the different approaches to pancreatic islet research
  • Includes supplementary material: sn.pub/extras

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xvi
    Download chapter PDF

  2. The Pathobiology of Diabetes Mellitus

    • Alicia J. Jenkins, David N. O’Neal, Christopher J. Nolan, Andrzej S. Januszewski
    Pages 1-48

  3. Comparative Analysis of Islet Development

    • Ananta Poudel, Omid Savari, Zehra Tekin, Manami Hara
    Pages 49-63

  4. Mathematical Modeling of Islet Generation, Degeneration and Regeneration

    • Junghyo Jo, Deborah A. Striegel, Manami Hara, Vipul Periwal
    Pages 65-81

  5. Epigenetic Regulation of Islet Development and Regeneration

    • Satyajeet Khare, Prachi Katre, Sanjeev Galande
    Pages 83-109

  6. Pancreatic Regeneration After Partial Pancreatectomy in Rodents

    • Wan-Chun Li, Chang-Yi Chen, Hung-Yu Chien, Susan Bonner-Weir
    Pages 111-123

  7. Regulators of Beta-Cell Death and Regeneration

    • Shin Takasawa, Asako Itaya-Hironaka, Akiyo Yamauchi, Hiroyo Ota, Maiko Takeda, Sumiyo Sakuramoto-Tsuchida et al.
    Pages 125-158

  8. MicroRNAs: A Link Between Type 1 Diabetes and the Environment?

    • Ammira Al-Shabeeb Akil, Andy Ho, Carah A. Figueroa-Crisostomo, William D. Rawlinson, Maria E. Craig
    Pages 159-192

  9. Transdifferentiation of Extra-Pancreatic Tissues for Cell Replacement Therapy for Diabetes

    • Irit Meivar-Levy, Hila Barash, Sarah Ferber
    Pages 193-215

  10. Generation of Human Islet Progenitor Cells via Epithelial-to-Mesenchymal Transition

    • Wilson Wong, Anandwardhan A. Hardikar, Mugdha V. Joglekar
    Pages 217-240

  11. Viral-Mediated Gene Therapy for the Generation of Artificial Insulin-Producing Cells as a Therapeutic Treatment for Type 1 Diabetes Mellitus

    • Dario Gerace, Rosetta Martiniello-Wilks, Ann M. Simpson
    Pages 241-255

  12. Regenerative Medicine: Clinical Islet Transplantation

    • Helen E. Thomas, Kate L. Graham, Thomas Loudovaris, Thomas W. H. Kay
    Pages 257-283

  13. Beta Cell Therapies for Type 1 Diabetes

    • Wayne John Hawthorne
    Pages 285-322

  14. Back Matter

    Pages 323-324
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Keywords

About this book

This comprehensive volume discusses in vitro laboratory development of insulin-producing cells. It encompasses multiple aspects of islet biology—from embryonic development and stem cell differentiation to clinical studies in islet transplantation, regulation of islet beta-cell regeneration, pancreatic progenitors, mathematical modelling of islet development, epigenetic regulation, and much more. The chapter authors represent leading laboratories from around the world who contribute their international perspectives and global expertise. Collectively, they provide the reader with a concise yet detailed knowledge of processes and current developments in islet regenerative biology.

Pancreatic Islet Biology, part of the Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers and clinicians in stem cells or endocrinology, especially those focusing on diabetes. 

Editors and Affiliations

  • NHMRC Clinical Trials Centre Diabetes and Islet-biology Group, The University of Sydney Faculty of Medicine, Sydney, Australia

    Anandwardhan A. Hardikar

About the editor

Anandwardhan A. Hardikar, Ph.D., currently leads Islet Biology and Diabetes research at the National Health and Medical Research Council’s (NHMRC) Clinical Trials Centre, at the University of Sydney, Australia. He received his Master’s in 1996, specializing in Genetics and then a Ph.D. in Diabetes research from the University of Pune, India (December 2000). After his initial postdoctoral work (on Pdx1) at the University of Pennsylvania, School of Medicine and then on islet xenotransplantation at the University of New South Wales, Sydney, Australia, he joined the NIDDK, National Institutes of Health in Bethesda, MD, to continue his research interests on lineage-committed pancreatic progenitor cells.  He started his own group at the National Center for Cell Science in Pune, India in 2006 and migrated to Australia towards the end of 2009. His research currently focuses on molecular biomarkers of beta cell death and type 1 diabetes progression, assessing the role of biota in diabetes,and understanding the epigenetic regulation of insulin-producing cells.

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