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  • © 2017

Ageing: Lessons from C. elegans

  • Provides a complete overview of the current state of ageing research in C. Elegans
  • Offers a unique focus on relevance for human ageing
  • Written by world’s leading researchers in the field of C. elegans ageing

Part of the book series: Healthy Ageing and Longevity (HAL)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-vi
  2. Introduction

    • Anders Olsen, Matthew S. Gill
    Pages 1-7
  3. Effects of Ageing on the Basic Biology and Anatomy of C. elegans

    • Laura A. Herndon, Catherine A. Wolkow, Monica Driscoll, David H. Hall
    Pages 9-39
  4. Dauer Formation and Ageing

    • Pedro Reis-Rodrigues, Kailiang Jia, Matthew S. Gill
    Pages 41-62
  5. Longevity Regulation by Insulin/IGF-1 Signalling

    • Seon Woo A. An, Murat Artan, Sangsoon Park, Ozlem Altintas, Seung-Jae V. Lee
    Pages 63-81
  6. Mitochondrial Longevity Pathways

    • Alfonso Schiavi, Natascia Ventura
    Pages 83-108
  7. Influences of Germline Cells on Organismal Lifespan and Healthspan

    • Francis R. G. Amrit, Arjumand Ghazi
    Pages 109-135
  8. Reproductive Ageing

    • Cheng Shi, Coleen T. Murphy
    Pages 137-162
  9. Nervous System Ageing

    • Claire BĂ©nard, Maria Doitsidou
    Pages 163-189
  10. Stress Response Pathways

    • Dana L. Miller, Joseph Horsman, Frazer I. Heinis
    Pages 191-217
  11. Oxidative Stress

    • Bart P. Braeckman, Patricia Back, Filip Matthijssens
    Pages 219-244
  12. Genome Stability and Ageing

    • Aditi U. Gurkar, Matthew S. Gill, Laura J. Niedernhofer
    Pages 245-264
  13. Protein Homeostasis and Ageing in C. elegans

    • Silvestre Alavez
    Pages 265-283
  14. Translational Control of Longevity

    • Jarod Rollins, Aric Rogers
    Pages 285-305
  15. Lipid Metabolism, Lipid Signalling and Longevity

    • Jonathon Duffy, Ayse Sena Mutlu, Meng C. Wang
    Pages 307-329
  16. Autophagy and Ageing

    • Malene Hansen
    Pages 331-354
  17. Dietary Restriction in C. elegans

    • Yue Zhang, William B. Mair
    Pages 355-391
  18. Integration of Metabolic Signals

    • Dana A. Lynn, Sean P. Curran
    Pages 393-409
  19. Microbiota, Probiotic Bacteria and Ageing

    • Katrine V. Christensen, Maria G. Morch, Tine H. Morthorst, Simon Lykkemark, Anders Olsen
    Pages 411-429
  20. The Future of Worm Ageing

    • Gordon J. Lithgow
    Pages 431-435

About this book


This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in thebiomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans.

With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.

Editors and Affiliations

  • Department of Molecular Biology and Genetics, Aarhus University, Aarhus, Denmark

    Anders Olsen

  • Department of Metabolics & Aging, The Scripps Research Institute - Scripps Florida, Jupiter, USA

    Matthew S. Gill

Bibliographic Information

Buy it now

Buying options

eBook USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 199.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access