Overview
- First book that covers the expertise from systems biology and pharmacodynamics researchers in one place
- Outlines how systems pharmacology should reduce the high attrition in the drug development pipeline
- All case studies illustrate practical applications
Part of the book series: AAPS Advances in the Pharmaceutical Sciences Series (AAPS, volume 23)
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Table of contents (20 chapters)
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Systems Modeling
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Pharmacodynamics
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Multi-scale Models of Drug Action
Keywords
About this book
Editors and Affiliations
About the editors
Holly H.C. Kimko-SA"> is a senior pharmacometrician in the Global Clinical Pharmacology department at Janssen Research & Development, LLC, Spring House, PA, and Adjunct Associate Professor in the Pharmacy School of Rutgers University, New Jersey. Dr. Kimko is a Janssen Research Fellow and American Association of Pharmaceutical Scientists Fellow. She championed the use of modeling and simulations in drug development at the Center for Drug Development Science at Georgetown University Medical School, Washington, DC in 1995–2002. Trained in biochemistry and pharmacy, Dr. Kimko earned her Ph.D. degree in pharmaceutical sciences from the University at Buffalo, State University of New York. She has published key papers on physiologically-based indirect response modeling and applications of clinical trial simulations and has edited two books on clinical trial simulations. Her research interests include strategic application of modeling and simulation tools in all aspects of drug development and post-approval life cycle management. Among her scientific endeavors is a specialty in pediatric drug development.
Bibliographic Information
Book Title: Systems Pharmacology and Pharmacodynamics
Editors: Donald E. Mager, Holly H.C. Kimko
Series Title: AAPS Advances in the Pharmaceutical Sciences Series
DOI: https://doi.org/10.1007/978-3-319-44534-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: American Association of Pharmaceutical Scientists 2016
Hardcover ISBN: 978-3-319-44532-8Published: 16 December 2016
Softcover ISBN: 978-3-319-83074-2Published: 04 July 2018
eBook ISBN: 978-3-319-44534-2Published: 29 November 2016
Series ISSN: 2210-7371
Series E-ISSN: 2210-738X
Edition Number: 1
Number of Pages: XIII, 511
Number of Illustrations: 56 b/w illustrations, 57 illustrations in colour
Topics: Pharmaceutical Sciences/Technology, Mathematical and Computational Biology, Medical Biochemistry