Editors:
- Practical cardiac genetics textbook for the clinician
- Containing detailed information on disease-causing genes
- Bench-to-bedside approach
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Table of contents (24 chapters)
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Front Matter
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Genetics
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Front Matter
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About this book
Clinical management and signs are the focus of this practical cardiogenetic reference for those who are involved in the care for cardiac patients with a genetic disease. With detailed discussion of the basic science of cardiogenetics in order to assist in the clinical understanding of the topic.
The genetic causes of various cardiovascular diseases are explained in a concise clinical way that reinforces the current management doctrine in a practical manner.
The authors will cover the principles of molecular genetics in general but also specific to cardiac diseases. They will discuss the etiology, pathogenesis, pathophysiology, clinical presentation, clinical diagnosis, molecular diagnosis and treatment of each cardiogenetic disease separately. Therapy advice, ICD indications, indications for and manner of further family investigation will all be covered, while each chapter will also contain take-home messages to reinforce the key points. The chapters reviewing the different diseases will each contain a table describing the genes involved in each. Each chapter will also contain specific illustrations, cumulatively giving a complete, practical review of each cardiogenetic disease separately.
Special emphasis will be given to advice on how to diagnose and manage cardiogenetic diseases in clinical practice, which genes should be investigated and why, and the pros and cons of genetic testing. Guidelines for investigation in families with sudden cardiac death at young age will also be included.
This book will be written for the general cardiologist and the clinical geneticist who is involved in cardiac patients and will provide answers to question such as:
Which genes are involved and which mutations? What is the effect of the mutation at cellular level? Which genes should be tested and why? What is the value of a molecular diagnosis? Does it influence therapy? When should the first degree relatives be tested and in which way?
Editors and Affiliations
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Department of Cardiology, St. Elisabeth-TweeSteden Ziekenhuis, Tilburg, The Netherlands
Hubert F. Baars
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Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
Pieter A. F. M. Doevendans
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Department of Clinical Genetics, VU University Medical Center, Amsterdam, The Netherlands
Arjan C. Houweling
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Department of Clinical Genetics, Academic Medical Center, Amsterdam, The Netherlands
J. Peter van Tintelen
About the editors
H. F. Baars
St. Elisabeth TweeSteden Ziekenhuis,
Department of Cardiology,
Tilburg, The Netherlands
Bergman Clinics Bilthoven
Bilthoven, The Netherlands
University Medical Center Utrecht,
Department of Cardiology,
Utrecht, The Netherlands
P. A. F. M. DoevendansUniversity Medical Center Utrecht,
Department of Cardiology,
Utrecht, The Netherlands
A.C. Houweling
VU University Medical Center,
Department of Clinical Genetics,
Amsterdam, The Netherlands
J. P. van Tintelen
Academic Medical Center,
Department of Clinical Genetics,
Amsterdam, The Netherlands
Bibliographic Information
Book Title: Clinical Cardiogenetics
Editors: Hubert F. Baars, Pieter A. F. M. Doevendans, Arjan C. Houweling, J. Peter van Tintelen
DOI: https://doi.org/10.1007/978-3-319-44203-7
Publisher: Springer Cham
eBook Packages: Medicine, Medicine (R0)
Copyright Information: Springer International Publishing Switzerland 2016
eBook ISBN: 978-3-319-44203-7Published: 30 November 2016
Edition Number: 2
Number of Pages: VIII, 405
Number of Illustrations: 38 b/w illustrations, 55 illustrations in colour
Topics: Cardiology, Human Genetics