Editors:
Written by experts in pendrin research
Provides readers with detailed knowledge about pendrin genetics, structure and pharmacology
Helps in understanding the molecular mechanisms of pendrin related disorders
Combines in the best way cutting-edge research with clinical aspects of pendrin function
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Table of contents (11 chapters)
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Front Matter
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The Role of Pendrin in the Inner Ear
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Front Matter
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The Role of Pendrin in the Thyroid
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Front Matter
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The Role of Pendrin in the Kidney
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Front Matter
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The Role of Pendrin in the Airways
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Front Matter
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The Pendrin Gene and Protein
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Front Matter
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Back Matter
About this book
This book reviews the current state of knowledge on the genetics, molecular biology and physiology of pendrin, with a particular focus on pendrin dysfunction and the consequences for human health.
Pendrin is a membrane transport protein expressed in the thyroid, inner ear, kidney and airways, and was recently found in a variety of other tissues and organs. Pendrin malfunction may cause a genetic disease called Pendred syndrome or non-syndromic deafness.
The book provides a thorough description of the multifaceted role of pendrin in human health and disease. As such, it offers an invaluable tool for physiology and pathology researchers, while also providing essential guidance for otorhinolaryngologists and endocrinologists in the diagnosis of Pendred syndrome and pendrin-related deafness.
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Editors and Affiliations
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Paracelsus Medical University Institute of Pharmacology and Toxicology, Salzburg, Austria
Silvia Dossena
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Paracelsus Medical University Institut of Pharmacology and Toxicology, Salzburg, Austria
Markus Paulmichl
About the editors
Silvia Dossena, PhD Institute of Pharmacology and Toxicology of the Paracelsus Medical University Salzburg, Austria
Bibliographic Information
Book Title: The Role of Pendrin in Health and Disease
Book Subtitle: Molecular and Functional Aspects of the SLC26A4 Anion Exchanger
Editors: Silvia Dossena, Markus Paulmichl
DOI: https://doi.org/10.1007/978-3-319-43287-8
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2017
Hardcover ISBN: 978-3-319-43285-4Published: 10 March 2017
Softcover ISBN: 978-3-319-82780-3Published: 20 July 2018
eBook ISBN: 978-3-319-43287-8Published: 02 March 2017
Edition Number: 1
Number of Pages: X, 226
Number of Illustrations: 10 b/w illustrations, 26 illustrations in colour
Topics: Molecular Medicine, Otorhinolaryngology, Endocrinology, Human Genetics