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Gastrointestinal Stromal Tumors

Bench to Bedside

  • Book
  • © 2017

Overview

Editors:
  1. Charles R. Scoggins

    1. School of Medicine, University of Louisville, Louisville, USA

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  2. Chandrajit P. Raut

    1. Brigham & Women’s Hospital, Harvard Medical School, Boston, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. John T. Mullen

    1. Harvard Medical School, Boston, USA

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  • Provides a concise yet comprehensive summary of the current status of the field

  • Written by experts in their fields

  • Richly illustrated with photographs and illustrations

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Table of contents (16 chapters)

  1. Front Matter

    Pages i-xi
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  2. History of GIST

    • Christina L. Roland, Barry W. Feig
    Pages 1-5

  3. Epidemiology of GIST

    • Taylor M. Coe, Jason K. Sicklick
    Pages 7-15

  4. Surgical Pathology of Gastrointestinal Stromal Tumors: Correlation with Clinical and Molecular Subtypes

    • Odise Cenaj, Vickie Y. Jo, Leona A. Doyle
    Pages 17-43

  5. Inherited GIST

    • Katherine A. Janeway
    Pages 45-57

  6. Localized Disease

    1. Front Matter

      Pages 59-59
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    2. Natural History and Prognosis of Localized Gastrointestinal Stromal Tumors in the Pre- and Post-imatinib Eras

      • Zhi Ven Fong, John T. Mullen
      Pages 61-72

    3. Imaging and Response Evaluation of Gastrointestinal Stromal Tumors

      • Sooyoung Shin, Haesun Choi
      Pages 73-89

    4. Endoscopic Evaluation of Gastrointestinal Stromal Tumors

      • Osman Yuksel, William R. Brugge
      Pages 91-102

    5. Endoscopic Management of Small GIST

      • Kavitha M. Nair, Field F. Willingham
      Pages 103-115

    6. Operative Management of Gastrointestinal Stromal Tumors

      • Jack W. Rostas, Prejesh Philips
      Pages 117-128

    7. Minimally Invasive Approaches to Gastrointestinal Stromal Tumors (GISTs)

      • Tiffany C. Cox, Vedra A. Augenstein, Sam Schell, B. Todd Heniford
      Pages 129-144

    8. Neoadjuvant Therapy and Surgical Consolidation for Localized Gastrointestinal Stromal Tumors

      • W. W. Tseng, S. Chopra, E. Jung, B. L. Eisenberg
      Pages 145-154

  7. Advanced Disease

    1. Front Matter

      Pages 155-155
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    2. Prognostic Factors for Advanced GIST

      • Christian F. Meyer
      Pages 157-170

    3. Advances on Molecular Characterization and Targeted Therapies on GIST

      • Gabriel Tinoco, Guozhi Hu, Ana Paz-Mejía, Jonathan Trent
      Pages 171-185

    4. Multimodality Therapy for Metastatic Gastrointestinal Stromal Tumor

      • David A. Mahvi, Emily Z. Keung, Chandrajit P. Raut
      Pages 187-208

    5. Management of Liver Metastases of Gastrointestinal Stromal Tumors

      • Andrew D. Morris, Shishir K. Maithel, David A. Kooby
      Pages 209-223

    6. Surgical Palliation

      • Brittany A. Potz, Thomas J. Miner
      Pages 225-239

  8. Back Matter

    Pages 241-243
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Keywords

About this book

This textbook provides a comprehensive, state of the art review of this field, and will serve as a valuable resource for clinicians, surgeons and researchers with an interest in GIST. The book  reviews new data about risk factors for the disease, profiles the new staging system for GIST, highlights our current understanding of genetic mutations that lead to GIST, and provides new perspectives about imaging of  GIST tumors. For localized disease, a greater appreciation of organ-sparing approaches and the importance of preservation of gastrointestinal function is discussed in detail, and advances in surgical techniques are highlighted, including minimally invasive surgery. For metastatic disease, the molecular biology of GIST is reviewed in a detailed and understandable manner, including the data that has fostered novel targeted approaches that have revolutionized management. Several landmark trials have been published in the last few years and are placed in context with respect to current management. Integration of surgery and systemic therapy through consolidative approaches has yielded provocative data that promises to further advance the field, and major advances in this domain are also discussed.   Gastrointestinal Stromal Tumors: Bench to Bedside will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging malignancy. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.  

Editors and Affiliations

  • School of Medicine, University of Louisville, Louisville, USA

    Charles R. Scoggins

  • Brigham & Women’s Hospital, Harvard Medical School, Boston, USA

    Chandrajit P. Raut

  • Harvard Medical School, Boston, USA

    John T. Mullen

About the editors

Charles R. Scoggins, University of Louisville, School of Medicine, 315 E. Broadway, Suite 303, 40202 Louisville, KY, USA, e-mail: charles.scoggins@louisville.edu

Chandrajit P. Raut, Brigham & Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, Department of Surgery, 75 Francis St., Boston, MA, USA, 02115 e-mail: craut@bwh.harvard.edu

John T. Mullen, Division of Surgical Oncology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Yawkey 7B, Boston, MA  02114, E-mail:  jmullen@mgh.harvard.edu

Bibliographic Information

  • Book Title: Gastrointestinal Stromal Tumors

  • Book Subtitle: Bench to Bedside

  • Editors: Charles R. Scoggins, Chandrajit P. Raut, John T. Mullen

  • DOI: https://doi.org/10.1007/978-3-319-42632-7

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2017

  • Hardcover ISBN: 978-3-319-42630-3Published: 23 December 2016

  • Softcover ISBN: 978-3-319-82623-3Published: 30 April 2018

  • eBook ISBN: 978-3-319-42632-7Published: 10 December 2016

  • Edition Number: 1

  • Number of Pages: XI, 243

  • Number of Illustrations: 37 b/w illustrations, 24 illustrations in colour

  • Topics: Surgical Oncology, General Surgery, Gastroenterology

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