Selenium

1. Front Matter

   Pages i-xxxi

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2. The Machinery of Selenoprotein Biosynthesis

   1. Front Matter

      Pages 1-1

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   2. Selenocysteine tRNA[Ser]Sec: From Nonsense Suppressor tRNA to the Quintessential Constituent in Selenoprotein Biosynthesis

      • Bradley A. Carlson, Byeong Jae Lee, Petra A. Tsuji, Ryuta Tobe, Jin Mo Park, Ulrich Schweizer et al.

      Pages 3-12

   3. Eukaryotic Mechanisms of Selenocysteine Incorporation and Its Reconstitution In Vitro

      • Mark H. Pinkerton, Paul R. Copeland

      Pages 13-24

   4. Probing Selenoprotein Translation by Ribosome Profiling

      • Michael T. Howard

      Pages 25-37

   5. Pathways in De Novo Biosynthesis of Selenocysteine and Cysteine in Eukaryotes

      • Vadim N. Gladyshev, Bradley A. Carlson, Dolph L. Hatfield

      Pages 39-45

   6. Prokaryotic Selenoprotein Biosynthesis and Function

      • Michael Rother

      Pages 47-58

   7. The Role of Selenium in Human Evolution

      • Louise White, Sergi Castellano

      Pages 59-71

   8. The Chemistry of Selenocysteine in Proteins

      • Rebecca N. Dardashti, Linoy Dery, Reem Mousa, Shahar Dery, Post S. Reddy, Norman Metanis

      Pages 73-83

   9. Evolution of Selenophosphate Synthetase

      • Marco Mariotti, Didac Santesmasses, Roderic Guigó

      Pages 85-99

   10. Structure and Mechanism of Selenocysteine Synthases

       • Malgorzata Dobosz-Bartoszek, Miljan Simonović

       Pages 101-112

   11. Mechanism, Structure, and Biological Role of Selenocysteine Lyase

       • Hisaaki Mihara, Ryuta Tobe, Nobuyoshi Esaki

       Pages 113-123

3. Selenoproteins, Their Occurrence and Function

   1. Front Matter

      Pages 125-125

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   2. Eukaryotic Selenoproteomes

      • Vadim N. Gladyshev

      Pages 127-139

   3. Prokaryotic Selenoproteins and Selenoproteomes

      • Yan Zhang

      Pages 141-150

   4. Functional Genomics of Selenoproteins and Se-responsive Pathways

      • Catherine Méplan, John Hesketh

      Pages 151-173

   5. Selenium Regulation of the Selenoprotein and Non-selenoprotein Transcriptomes in a Variety of Species

      • Roger A. Sunde

      Pages 175-186

   6. 77Se NMR Spectroscopy of Selenoproteins

      • Jun Liu, Sharon Rozovsky

      Pages 187-198

   7. Thioredoxin Reductase 1 as an Anticancer Drug Target

      • Edward E. Schmidt, Elias S. J. Arnér

      Pages 199-209

   8. Basics and News on Glutathione Peroxidases

      • Leopold Flohé, Regina Brigelius-Flohé

      Pages 211-222

In the current edition, Selenium: Its Molecular Biology and Role in Human Health expands extensively on the previous editions providing readers with the most significant advances in the rapidly developing selenium field. Evidence from epidemiology and veterinary science supports the essential role of selenium in (human) health, but its split personality in both preventing and supporting cancer and also in promoting insulin resistance has become more clearly defined. The pivotal role of glutathione peroxidase 4 in a new process of programmed cell death, ferroptosis, brings new impetus to the field. Recently defined mutations in selenoprotein and biosynthesis factor genes have been identified in patients, and the resulting disorders further emphasize the significance of selenoproteins in human health. The mechanism of selenoprotein biosynthesis, the functions of selenoproteins, and the roles of dietary selenium have been further elucidated, and new regulatory mechanisms involving selenoproteins discovered. The book, therefore, covers the breadth of current selenium research. With up-to-date chapters written by leaders in their fields, it serves as an invaluable resource for novices as well as specialists.

• biosynthesis
• selenoprotein
• tRNA
• Selenocysteine
• ribosome profiling
• selenophosphate
• thioredoxin system
• T function
• inflammation

“The book provides up to date and comprehensive review of hot topics in the field of Se research and is the source of valuable information for people working in science, clinics and industry.” (Jela Brozmanova, Neoplasma, Vol. 64 (3), 2017)

• Mouse Cancer Genetics Program, National Institutes of Health, National Cancer Institute, Bethesda, USA

  Dolph L. Hatfield

• Institut für Biochemie und Molekularbiologie, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany

  Ulrich Schweizer

• Department of Biological Sciences, Towson University, Towson, USA

  Petra A. Tsuji

• Division of Genetics, Department of Medicine, Brigham and Women’s Hospital Harvard Medical School, Boston, USA

  Vadim N. Gladyshev

Dolph Hatfield is Scientist Emeritus in the Molecular Biology of Selenium Section at the National Cancer Institute.

Ulrich Schweizer, is Professor at the Institute of Biochemistry and Molecular Biology, Rheinische Friedrich-Wilhelms-Universität Bonn.

Petra Tsuji is Assistant Professor in the at the Department of Biological Sciences at Towson University.

Vadim N. Gladyshev, is Professor in the Division of Genetics, Department of Medicine at the Brigham and Women’s Hospital and Harvard Medical School.

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