Overview
- and only fragmentarily in specialized journals
- Important advancements have been recorded in the field of systemic vasculitides in the last couple of years. The large majority of these advancements cannot be retrieved in the most recently published books devoted to vasculitides, mentioned below
- A fully updated volume is useful not only for experienced researchers and clinicians, but especially for postgraduate students and general practitioners who usually have a limited experience with vasculitis syndromes that must be diagnosed as early as possible to prevent a rapidly progressing and often life-threatening or lethal course
- In addition to conventional treatments, a number of biological drugs and monoclonal antibodies have been recently administered to relapsing and refractory patients. How to choose among the different therapeutic combinations cannot be found elsewhere, whereas this crucial problem is properly addressed and critically discussed comprehensively in this book
- Includes supplementary material: sn.pub/extras
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Table of contents (35 chapters)
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Front Matter
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Biology of Blood Vessels, Experimental Models and Nomenclature of Vasculitides
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Front Matter
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Primary Systemic Vasculitides
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Front Matter
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Keywords
About this book
In spite of their relatively low prevalence, systemic vasculitides have been the object of intensive basic and clinical investigations over the last few years. As a consequence, important advancements have been achieved: from updated diagnostic and classification criteria and a more rational nomenclature to the recognition of an expanding spectrum of clinical manifestations and potentially devastating complications; from the recognition of the viral etiology of conditions such as HCV-related cryoglobulinemic vasculitis and HBV-associated polyarteritis nodosa to newly named variable vessel vasculitis exemplified by Behçet’s disease; from single-organ vasculitis such as central nervous system vasculitis to the more recently emerging features of the IgG4-related, immune-mediated diseases that are showing remarkable clinical heterogeneity. In addition, intriguing pathogenetic hypotheses are being reported for certain chronic, relapsing vasculitides that are improving our understanding of their biology and basic pathophysiology. New avenues are being explored that will hopefully allow a deeper comprehension of the relationships between certain virus-driven vasculitides and lymphoproliferation, and possibly lead to the identification of novel biomarkers that may be used to single out patients at an increased risk of relapse. This explosion of knowledge is obviously resulting in state-of-the-art, personalized treatments of systemic vasculitides.
This book is a collection of reviews on the major vasculitides, written by scientists and clinicians with a multi-year experience in this field. We hope it will provide the reader with a stimulating container of new advances in scientific knowledge and more rational therapeutic approaches to this fascinating chapter of pathology.Editors and Affiliations
About the editors
Franco Dammacco is Emeritus Professor of Internal Medicine at the University of Bari Medical School and has been President of the Italian Society of Internal Medicine. His research and clinical interests include HCV-related cryoglobulinemic vasculitis, onco-hematology, connective tissue diseases and immunodeficiency syndromes. He is author or co-author of more than 470 papers and Editor-in-Chief of the journal Clinical and Experimental Medicine.
Domenico Ribatti is full Professor of Human Anatomy at the University of Bari Medical School. His main research topics are angiogenesis and anti-angiogenesis, with special emphasis for hematological malignancies, tumor microcirculation, and immunological competence. He is author of over 650 papers and 8 monographs.
Angelo Vacca is full Professor of Internal Medicine at the University of Bari Medical School and President of the Italian Society of Immunology, Clinical Immunology and Allergology. He isactively involved in research areas such as angiogenesis and tumor progression, multiple myeloma and related malignancies, biological markers of tumor invasion and metastasis, and controlled chemotherapy studies. On these topics he has published over 300 papers.
Bibliographic Information
Book Title: Systemic Vasculitides: Current Status and Perspectives
Editors: Franco Dammacco, Domenico Ribatti, Angelo Vacca
DOI: https://doi.org/10.1007/978-3-319-40136-2
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-40134-8Published: 24 October 2016
Softcover ISBN: 978-3-319-82038-5Published: 30 April 2018
eBook ISBN: 978-3-319-40136-2Published: 13 October 2016
Edition Number: 1
Number of Pages: XI, 438
Number of Illustrations: 23 b/w illustrations, 55 illustrations in colour
Topics: Immunology, Neurosciences, Pharmacology/Toxicology, Virology