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  • © 2016

Molecular and Cellular Biology of Platelet Formation

Implications in Health and Disease

  • Focus is set on platelet biogenesis

  • Describes cell and molecular platelet biology as well as clinical aspects

  • Includes the use of diverse animal models for platelet research

  • Written by internatinoal leading figures

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Table of contents (21 chapters)

  1. Front Matter

    Pages i-x
  2. Megakaryocytes and Thrombopoiesis

    1. Front Matter

      Pages 1-1
    2. Megakaryopoiesis and Platelet Biogenesis

      • Joseph E. Italiano Jr.
      Pages 3-22
    3. Impact of the Megakaryocytic Vascular Niche on Platelet Biogenesis

      • Harald Schulze, Daniela Semeniak, Alessandra Balduini
      Pages 93-114
    4. Morphogenesis of Platelets in the Circulation

      • Matthew T. Rondina, Hansjörg Schwertz
      Pages 115-129
  3. Platelet Biology: Signals and Functions

    1. Front Matter

      Pages 131-131
    2. Platelet Contents

      • Robert Flaumenhaft, Secil Koseoglu
      Pages 133-152
    3. Signalling Pathways Regulating Platelet Biogenesis

      • Alexandra Mazharian, Yotis A. Senis
      Pages 153-173
    4. Rap GTPase Signaling in Platelets and Megakaryocytes

      • Wolfgang Bergmeier, Ellen C. O’Shaughnessy
      Pages 175-191
    5. Regulation of Megakaryocyte and Platelet Survival

      • Amanda E. Au, Marion Lebois, Irina Pleines, Emma C. Josefsson
      Pages 193-220
    6. Platelet Functions Beyond Hemostasis

      • Rick Kapur, John W. Semple
      Pages 221-237
    7. Mouse Models for Platelet Production and Function

      • Markus Bender, Bernhard Nieswandt
      Pages 239-263
  4. Platelets in Health and Disease

    1. Front Matter

      Pages 265-265
    2. Fetal and Neonatal Megakaryopoiesis and Platelet Biology

      • Christof Dame, Viola Lorenz, Martha Sola-Visner
      Pages 267-291
    3. Platelets in Ischemic Stroke

      • Deya Cherpokova, Bernhard Nieswandt
      Pages 293-306
    4. Acquired Thrombocytopenia

      • Tamam Bakchoul, Andreas Greinacher
      Pages 327-349
    5. Megakaryocytes and Platelet Production During Viral Infection

      • Günther Schönrich, Martin J. Raftery
      Pages 351-362

About this book

This book gives a comprehensive insight into platelet biogenesis, platelet signal transduction, involvement of platelets in disease, the use of diverse animal models for platelet research and future perspectives in regard to platelet production and gene therapy. Being written by international experts, the book is a concise state-of-the art work in the field of platelet biogenesis, biology and research. It represents an indispensable tool for research scientists in biomedicine, vascular biology, hematopoiesis and hemostasis and specifically for scientists in platelet research, as well as for clinicians in the field of hematology and transfusion medicine.​

 

Reviews

“This book is true to its title, detailing the current state of research in the molecular and cellular biology of platelet formation. … the book would be of interest to anyone interested in platelet biogenesis -- from basic science and translational science researchers, to practicing clinicians … . It's a great read for anyone interested in what's happening in platelet research. I enjoyed reading this book and being brought up to speed with what's happening in platelet research today.” (Valerie L. Ng, Doody's Book Reviews, May, 2017)

Editors and Affiliations

  • Institute of Experimental Biomedicine I, University Hospital Würzburg, Würzburg, Germany

    Harald Schulze

  • Vascular Biology Programm, Harvard Medical School, Boston, USA

    Joseph Italiano

About the editors

P.D. Dr. Harald Schulze, studied biochemistry at the University of Hannover and at the Hannover Medical Faculty. As PostDoctoral Assistant at the Dana-Farber Cancer Insitute, Harvard Medical School, Boston, USA, he performed research on megakaryocytes and platelet biogenesis. Since 2005 Harald Schulze is Group leader and Head of the Laboratory for Pediatric Molecular Biology, Charité in Berlin. His group studies the basic mechanisms of platelet production from megakaryocytes. Another focus of the laboratory lies in the analysis of the rare congenital disorder, the TAR syndrome, which is based on a defective mechanism in hematopoiesis.

Dr. Joseph E. Italiano Jr. received his PhD from Florida State University and trained as a Post-Doctoral Fellow in the Division of Hematology at Brigham and Women’s Hospital from 1998-2000. He is currently Associate Professor of Medicine with appointments in the Division of Hematology at Brigham and Women’s Hospital, the Vascular Biology Program at Children’s Hospital Boston, and Harvard Medical School. His research focuses on how megakaryocytes produce platelets and how platelets regulate new blood vessel growth.

Bibliographic Information

  • Book Title: Molecular and Cellular Biology of Platelet Formation

  • Book Subtitle: Implications in Health and Disease

  • Editors: Harald Schulze, Joseph Italiano

  • DOI: https://doi.org/10.1007/978-3-319-39562-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-39560-9Published: 15 February 2017

  • Softcover ISBN: 978-3-319-81914-3Published: 17 July 2018

  • eBook ISBN: 978-3-319-39562-3Published: 07 February 2017

  • Edition Number: 1

  • Number of Pages: X, 460

  • Number of Illustrations: 15 b/w illustrations, 41 illustrations in colour

  • Topics: Human Physiology, Hematology, Cell Biology, Gene Therapy, Molecular Medicine, Blood Transfusion Medicine

Buy it now

Buying options

eBook USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 239.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 239.00
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access