Neurotoxin Modeling of Brain Disorders — Life-long Outcomes in Behavioral Teratology

1. Front Matter

   Pages i-viii

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2. Neuroteratology and Animal Modeling of Brain Disorders

   • Trevor Archer, Richard M. Kostrzewa

   Pages 1-40

3. Perinatal Lesioning and Lifelong Effects of the Noradrenergic Neurotoxin 6-Hydroxydopa

   • Richard M. Kostrzewa

   Pages 43-50

4. Selective Lifelong Destruction of Brain Monoaminergic Nerves Through Perinatal DSP-4 Treatment

   • Przemysław Nowak

   Pages 51-71

5. Noradrenergic–Dopaminergic Interactions Due to DSP-4–MPTP Neurotoxin Treatments: Iron Connection

   • Trevor Archer

   Pages 73-86

6. Perinatal Domoic Acid as a Neuroteratogen

   • Tracy A. Doucette, R. Andrew Tasker

   Pages 87-110

7. Perinatal 192 IgG-Saporin as Neuroteratogen

   • Laura Petrosini, Paola De Bartolo, Debora Cutuli, Francesca Gelfo

   Pages 111-123

8. NGF in Early Embryogenesis, Differentiation, and Pathology in the Nervous and Immune Systems

   • Luisa Bracci-Laudiero, Maria Egle De Stefano

   Pages 125-152

9. Disrupted Circadian Rhythm as a Common Player in Developmental Models of Neuropsychiatric Disorders

   • Eva M. Marco, Elena Velarde, Ricardo Llorente, Giovanni Laviola

   Pages 155-181

10. Neurobehavioral Effects from Developmental Methamphetamine Exposure

    • Sarah A. Jablonski, Michael T. Williams, Charles V. Vorhees

    Pages 183-230

11. Early-Life Toxic Insults and Onset of Sporadic Neurodegenerative Diseases—an Overview of Experimental Studies

    • Anna Maria Tartaglione, Aldina Venerosi, Gemma Calamandrei

    Pages 231-264

12. The Use of Perinatal 6-Hydroxydopamine to Produce a Rodent Model of Lesch–Nyhan Disease

    • Darin J. Knapp, George R. Breese

    Pages 265-277

13. Perinatal 6-Hydroxydopamine Modeling of ADHD

    • John P. Kostrzewa, Rose Anna Kostrzewa, Richard M. Kostrzewa, Ryszard Brus, Przemysław Nowak

    Pages 279-293

14. Attention-Deficit/Hyperactivity Disorder: Focus upon Aberrant N-Methyl-d-Aspartate Receptors Systems

    • Trevor Archer, Danilo Garcia

    Pages 295-311

15. Perinatal 6-Hydroxydopamine to Produce a Lifelong Model of Severe Parkinson’s Disease

    • John P. Kostrzewa, Rose Anna Kostrzewa, Richard M. Kostrzewa, Ryszard Brus, Przemysław Nowak

    Pages 313-332

16. Exercise and Nutritional Benefits in PD: Rodent Models and Clinical Settings

    • Trevor Archer, Richard M. Kostrzewa

    Pages 333-351

17. Lifelong Rodent Model of Tardive Dyskinesia—Persistence After Antipsychotic Drug Withdrawal

    • Richard M. Kostrzewa, Ryszard Brus

    Pages 353-362

18. Perinatal Influences of Valproate on Brain and Behaviour: An Animal Model for Autism

    • Peter Ranger, Bart A. Ellenbroek

    Pages 363-386

19. Applications of the Neonatal Quinpirole Model to Psychosis and Convergence upon the Dopamine D2 Receptor

    • Russell W. Brown, Daniel J. Peterson

    Pages 387-402

20. Postnatal Phencyclidine (PCP) as a Neurodevelopmental Animal Model of Schizophrenia Pathophysiology and Symptomatology: A Review

    • B. Grayson, S. A. Barnes, A. Markou, C. Piercy, G. Podda, J. C. Neill

    Pages 403-428

This book is authored by leading experts who made major discoveries in neuroteratology research focused on modeling human neural developmental disorders. Individual chapters address ADHD (attention-deficit hyperactivity disorder), Lesch-Nyhan disease, psychoses and schizophrenia, autism, and models of Parkinson’s Disease and tardive dyskinesia. The effects of perinatal stress and agonist insults on life-long outcomes are addressed, as well as the overall effects of perinatal neurotoxins on development of specific neural phenotypic systems. The book provides a unique compendium on how perinatal insults of various types can produce effects in brain that persist throughout the life span. Researchers can derive insight into experimental approaches in this research field; clinicians can develop insights into the influences of the many noxious and seemingly innocuous substances that might influence brain development in children.

• animal modeling of human disorders
• behavioral neuroteratology
• dopaminergic neurons
• glutamatergic neurons
• neurotoxins
• perinatal insults
• psychopharmacology

“This informative new book, written and edited by researchers in the field of the neuroteratology, presents the most recent data regarding how perinatal insults of various types can produce effects in the brain that persist throughout the lifespan. … The editors and chapter authors provide important information about toxic exposure during pregnancy. The target audience is ‘those engaged in studies in neuro- ontogeny; the book is also important collisions involved in the care of pregnant women or children.’” (Michael Joel Schrift, Doody's Book Reviews, December, 2016)

• Department of Biomedical Sciences, East Tennessee State University, Johnson City, USA

  Richard M. Kostrzewa

• Department of Psychology, University of Gothenburg, Gothenburg, Sweden

  Trevor Archer

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