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  • © 2016

Host Defense Peptides and Their Potential as Therapeutic Agents

  • Summarizes the latest developments in host defense peptides research
  • Explores potential therapeutic applications of host defense peptides
  • Written by international experts of host defense peptide research
  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-x
  2. Biological Targets of Host Defense Peptides

    1. Front Matter

      Pages 1-1
    2. Diversity in Host Defense Antimicrobial Peptides

      • Monique L. van Hoek
      Pages 3-26
    3. Antifungal Host Defense Peptides

      • Karl Lohner, Regina Leber
      Pages 27-55
    4. Antiviral Host Defence Peptides

      • Filipa Henderson Sousa, Victor Casanova, Craig Stevens, Peter G. Barlow
      Pages 57-94
    5. Anticancer Peptides: Prospective Innovation in Cancer Therapy

      • Diana Gaspar, Miguel A.R.B. Castanho
      Pages 95-109
    6. Plant Antimicrobial Peptides

      • Ravinder K. Goyal, Autar K. Mattoo
      Pages 111-136
  3. Immune Modulation by Host Defense Peptides

    1. Front Matter

      Pages 137-137
    2. Host Defense Peptides and the Eicosanoid Cascade

      • Min Wan, Xiao Tang, Jesper Z. Haeggström
      Pages 139-158
  4. Development of Resistance

    1. Front Matter

      Pages 159-159
    2. Bacterial Resistance to Host Defence Peptides

      • David A. Phoenix, Sarah R. Dennison, Frederick Harris
      Pages 161-204
  5. Recent Advances in Engineering Host Defense Peptides

    1. Front Matter

      Pages 227-227
    2. How to Teach Old Antibiotics New Tricks

      • Stephanie Deshayes, Michelle W. Lee, Nathan W. Schmidt, Wujing Xian, Andrea Kasko, Gerard C. L. Wong
      Pages 253-290
  6. Therapeutic Perspectives

    1. Front Matter

      Pages 291-291
    2. Antimicrobial Peptides and Preterm Birth

      • Catherine P James, Mona Bajaj-Elliott
      Pages 293-299
    3. Host Defense Peptides and Their Advancements in Translational Staphylococcus aureus Research

      • Sarah C. Mansour, Robert E.W. Hancock, Michael Otto
      Pages 301-321

About this book

This book offers an overview of our current understanding of host defense peptides and their potential for clinical applications as well as some of the obstacles to this. The chapters, written by leading experts in the field, detail the number and diversity of host defense peptides, and discuss the therapeutic potential not only of antibacterial, but also of antifungal, antiviral, plant antimicrobial and anticancer host defense peptides. The authors provide new insights into their mechanisms of action and their immunomodulatory properties, and review recent advances in the design of novel therapeutic molecules. Lastly, their potential to prevent preterm births and Staphylococcus aureus infections is highlighted. The book is of interest to researchers, industry and clinicians alike.

Editors and Affiliations

  • Health Sciences Centre, McMaster University, Hamilton, Canada

    Richard M. Epand

About the editor

RICHARD M. EPAND Professor Emeritus McMaster University Dept. of Biochemistry and Biomedical Sciences 4H28 Health Sciences Centre Hamilton, Ontario Canada L8S 4K1 Tel. 905-525-9140 ext. 22073 Email: epand@mcmaster.ca 450 publications

Bibliographic Information

  • Book Title: Host Defense Peptides and Their Potential as Therapeutic Agents

  • Editors: Richard M. Epand

  • DOI: https://doi.org/10.1007/978-3-319-32949-9

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-32947-5Published: 16 May 2016

  • Softcover ISBN: 978-3-319-81406-3Published: 27 May 2018

  • eBook ISBN: 978-3-319-32949-9Published: 06 May 2016

  • Edition Number: 1

  • Number of Pages: X, 321

  • Number of Illustrations: 9 b/w illustrations, 32 illustrations in colour

  • Topics: Protein Science, Immunology, Applied Microbiology, Medical Biochemistry, Microbiology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access