Laser-Driven Particle Acceleration Towards Radiobiology and Medicine

1. Front Matter

   Pages i-xviii

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2. Lasers Offer New Tools to Radiobiology and Radiotherapy

   • Antonio Giulietti, Toshiki Tajima

   Pages 1-15

3. Updating Radiobiology, Radiotherapy and Radiation Safety

   1. Front Matter

      Pages 17-17

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   2. Laser-Plasma Accelerators Based Ultrafast Radiation Biophysics

      • Yann A. Gauduel

      Pages 19-50

   3. Cyberknife, Dose Fractioning for Clinical Protocols

      • Raphaëlle Mouttet-Audouard, Thomas Lacornerie, Eric Lartigau

      Pages 51-65

   4. Radiation Therapy Towards Laser-Driven Particle Beams: An “OMICS” Approach in Radiobiology

      • Luigi Minafra, Valentina Bravatà, Francesco Paolo Cammarata, Giusi Irma Forte

      Pages 67-98

   5. Radiological Safety in Laser Facilities

      • Andrew Simons

      Pages 99-132

4. Updating Laser-driven Electron Acceleration and Dosimetry

   1. Front Matter

      Pages 133-133

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   2. Generation of Multi-GeV Electron Beams and Bio-medical Applications

      • Tae Moon Jeong, Jongmin Lee

      Pages 135-161

   3. Ionization Induced Electron Injection in Laser Wakefield Acceleration

      • Min Chen, Zheng-Ming Sheng

      Pages 163-182

   4. All-Optical X-Ray and γ-Ray Sources from Ultraintense Laser-Matter Interactions

      • Leonida A. Gizzi

      Pages 183-201

   5. Dosimetry of Laser-Driven Electron Beams for Radiobiology and Medicine

      • Luca Labate, Debora Lamia, Giorgio Russo

      Pages 203-218

5. Updating Laser-driven Ion Acceleration for Biomedical Applications

   1. Front Matter

      Pages 219-219

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   2. Laser-Driven Ion Accelerators: State of the Art and Applications

      • Marco Borghesi, Andrea Macchi

      Pages 221-247

   3. Biological Responses Triggered by Laser-Driven Ion Beams

      • Akifumi Yogo

      Pages 249-269

   4. High Resolution Ion and Electron Beam Radiography with Laser-Driven Clustered Sources

      • Anatoly Faenov, Tatiana Pikuz, Ryosuke Kodama

      Pages 271-294

   5. Recent Progress in Laser Ion Acceleration

      • Toshiki Tajima

      Pages 295-313

6. Back Matter

   Pages 315-320

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This book deals with the new method of laser-driven acceleration for application to radiation biophysics and medicine. It provides multidisciplinary contributions from world leading scientist in order to assess the state of the art of innovative tools for radiation biology research and medical applications of ionizing radiation. The book contains insightful contributions on highly topical aspects of spatio-temporal radiation biophysics, evolving over several orders of magnitude, typically from femtosecond and sub-micrometer scales. Particular attention is devoted to the emerging technology of laser-driven particle accelerators and their application to spatio-temporal radiation biology and medical physics, customization of non-conventional and selective radiotherapy and optimized radioprotection protocols.

• Innovative Radiotherapy
• Laser-Driven Particle Acceleration
• Laser-Plasma Interactions
• Multi-Gev Laser-Wakefield Accelerator
• Protontherapy of Cancer
• Radiobiological Tests
• Spatio-Temporal Radiation Biophysics
• Stable Production of Ultrashort Relativistic Electron Bunches
• Synchrotron Source Pre-Clinical Trials
• Ultrafast X-Ray Imaging of Living Cells

• Sezione "Adriano Gozzini", Istituto Nazionale di Ottica, Pisa, Italy

  Antonio Giulietti

Antonio Giulietti is a physicist operating at INO (National Institute of Optics, Italy). He has been CNR Research Director and Head of the Unit "Adriano Gozzini" of INO. He founded ILIL (Intense Laser Irradiation  Laboratory) in the CNR Campus of Pisa which has been operating for more than 20 years with scientific output and international collaboration making ILIL a primary reference in the domain of laser-plasmas. AG is author of more than 200 papers published on international refereed journals, mainly in the field of laser and plasma physics, plasma instabilities relevant to Inertial Fusion, radiation from plasmas, laser-driven particle acceleration and their biomedical potential. AG has organized and chaired a large number of international conferences on these topics. He is member of the International Advisory Board of the International Conference on High Energy Density Science, annually held in Yokohama. His research group has been supported by CNR, Italian Ministry of Education, Italian Ministry of Health, European Union, Extreme light Infrastructure (ELI), CEA (France), JSPS (Japan). AG has been very active in teaching and tutoring students and young scientists. Young scientists trained in the AG' lab are today Professors or Researchers in prestigious Universities or Research Institutions, including Universities of Pisa, Siena, Milano, Bordeaux, Oxford, Belfast, Ecole Polytechnique in Palaiseau, CEA-Saclay, BMI-Berlin, Rutherford Appleton Laboratory. In the last ten years 2006-2015 AG devoted most of his work at studying possible medical uses of laser-driven particle accelerators.  Experiments performed in Pisa and at CEA-Saclay led to the discovery of a high efficiency acceleration regime allowing the production of electron bunches whose charge and kinetic energy are suitable for radiotherapy. Those electrons were also used to drive a gamma sources and produce photo-activation, so opening a perspective of interest for nuclear medicine. In the meantime AG promoted R&D studies to achieve a practical usability of laser-driven accelerators in radiobiology and clinics, also in collaboration with CEA-Saclay and University of Osaka. In this framework he recently published (2015) a review paper on “Laser-Plasma Particle Sources for Biology and Medicine”. 

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