Molecular Targets and Strategies in Cancer Prevention

1. Front Matter

   Pages i-v

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2. Strategies to Target Pancreatic Cancer

   • Geou-Yarh Liou, Peter Storz

   Pages 1-20

3. Microbiota and Chronic Inflammation as Targets for Colorectal Cancer Prevention

   • Domenico Ciliberto, Lucia Fiorillo, Eleonora Iuliano, Teresa Del Giudice, Pierosandro Tagliaferri

   Pages 21-35

4. Challenges in Multiple Myeloma Chemoprevention: Potential Role of Natural, Synthetic and Endogenous Molecules

   • Nicola Amodio, Eugenio Morelli, Agnese Barone, Pierfrancesco Tassone

   Pages 37-60

5. Targeting MicroRNAs: Molecular Basis of Cancer Prevention

   • Yiwei Li, Fazlul H. Sarkar

   Pages 61-84

6. The Liquid Biopsies: A New Important Step in Cancer Research

   • Christian Rolfo, Jorge Chacártegui Borrás, Marco Giallombardo

   Pages 85-115

7. Targeting Tumor Angiogenesis for Cancer Prevention

   • Melissa García-Caballero, Beatriz Martínez Poveda, Miguel Ángel Medina, Ana Rodríguez Quesada

   Pages 117-149

8. miRNA as Prognostic and Therapeutic Targets in Tumor of Male Urogenital Tract

   • M. Caraglia, C. Alaia, A. Grimaldi, M. Boccellino, L. Quagliuolo

   Pages 151-171

9. Back Matter

   Pages 173-180

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The book focuses on the understanding of molecular pathways by which normal cell progress to the definable stage of cancer. The chapters explore microbiota and chronic inflammation, multiple myeloma chemoprevention, microRNAs, cancer regulation, liquid biopsies, and angiogenesis. Recent advances of molecular risk assessment, tumor microenvironment, microneoplasia, malignant gene expressions are highlighted to provide a means and design of future cancer prevention strategies and challenges thereupon. The volume also explores various receptor drugs that are in development process with the emphasis of inhibitors used to prevent malignant gene expression. The book bridges the gap between basic science and clinical application of current knowledge of cancer and emphasizes that tumor progression and cancer metastasis are not random - treatments and cure are logical and eventual.

Expertly authored and drawing from a wealth of international perspectives, Molecular Targets and Strategies in Cancer Prevention is invaluable reading for clinicians and researchers in the fields of oncology and molecular biology.

• cancer metastasis
• chemoprevention
• receptor tyrosine kinases
• signal transduction pathways
• tumor microenvironment

• Pharmaceutical Technology, Jadavpur University, Kolkata, India

  Malay Chatterjee

Dr. Malay Chatterjee, PhD, DSc, FAScT, is Emeritus Professor from the Department of Pharmaceutical Technology at Jadavpur University (India). He is also a Member of Pharmaceutical Education Board for the Government of India. Dr. Chatterjee has published over 165 scientific papers, 8 book chapters, and he has edited two contributed volumes--one is entitled Cell Signaling & Molecular Targets in Cancer, which was published by Springer in 2012. He is an Editorial Board member of several journals including, Research Journal of Medical Science, European Journal of General Medicine, and International Journal of Pharmacology, to name a few. He has received over 2122 citations.

Dr. Pierfrancesco Tassone is currently a Professor of Medical Oncology at the University "Magna Graecia" of Catanzaro. Dr. Tassone's research has taken him from the New York Medical College in Valhalla, NY to the Comprehensive Cancer Center, University of California San Diego, and later to the Dana Farber Cancer Institute and Harvard Medical School in Boston, Massachusetts. His research focuses on an approach of translational research integrating modern molecular acquisitions and new technologies to the methodological criteria of evidence-based medicine. In particular, Dr. Tassone generated monoclonal antibodies, identifying new tumor-associated antigens, and in recent years has studied the targeting of the tumor microenvironment for the development of new therapeutic strategies especially directed to multiple myeloma and methods of individualization of treatments cancer based on the genetic context and frameworks of hereditary-familial predisposition of breast cancer. He is author of over one hundred publications in prestigious international journals and has presented at conferences worldwide. 

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