Overview
- Editors:
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David M. Langenau
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Molecular Pathology and Cancer Center, Massachusetts General Hospital, CHARLESTOWN, USA
- Provides the most up-to-date research on zebrafish models for oncogene and tumor suppressor discovery
- Explores potential drug targets in various cancers, including leukemia, melanoma, pancreatic and liver cancers
- Reviews allograft cell transplantation and xenograft transplantation in zebrafish
- Includes supplementary material: sn.pub/extras
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Table of contents (23 chapters)
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Powers of the Zebrafish Model
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- Craig J. Ceol, Yariv Houvras
Pages 3-19
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- Marie Mayrhofer, Marina Mione
Pages 21-59
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- John M. Parant, Jing-Ruey Joanna Yeh
Pages 61-86
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- Michelle Dang, Rachel Fogley, Leonard I. Zon
Pages 103-124
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- Xiaoqian Huang, Ira Agrawal, Zhen Li, Weiling Zheng, Qingsong Lin, Zhiyuan Gong
Pages 147-168
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- Yelena Chernyavskaya, Brandon Kent, Kirsten C. Sadler
Pages 169-197
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- Jonathan W. Astin, Philip S. Crosier
Pages 199-218
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- Myron S. Ignatius, Madeline Hayes, David M. Langenau
Pages 219-237
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- C. Tulotta, S. He, W. van der Ent, L. Chen, A. Groenewoud, H. P. Spaink et al.
Pages 239-263
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- John C. Moore, David M. Langenau
Pages 265-287
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- Jaime Wertman, Chansey J. Veinotte, Graham Dellaire, Jason N. Berman
Pages 289-314
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- Wietske van der Ent, Wouter J. Veneman, Arwin Groenewoud, Lanpeng Chen, Claudia Tulotta, Pancras C. W. Hogendoorn et al.
Pages 315-332
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Cancer Models in Fish
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Front Matter
Pages 333-333
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- Nicholas R. Harrison, Fabrice J. F. Laroche, Alejandro Gutierrez, Hui Feng
Pages 335-369
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- Michael Phelps, Eleanor Chen
Pages 371-389
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- Katie L. Hwang, Wolfram Goessling
Pages 391-410
About this book
This volume focuses on defining the unique attributes of using the zebrafish cancer model for discovering important pathways and potential drug targets for the treatment of human cancers. Using the zebrafish model, the volume explores oncogene and tumor suppressor discovery, chemical genetic approaches, genomics, epigenetics, cancer imaging, and cell transplantation. Contributed chapters come from the most prominent laboratories working in this field, which provides a unique perspective on zebrafish models from a wide spectrum of the research community. In addition, the book offers a detailed analysis of the most current research in the area for specific zebrafish cancer models, including T cell leukemia, rhabdomyosarcoma, liver and pancreatic cancer, melanoma, neuroblastoma, germ cell tumors, and malignant peripheral sheath tumors. A chapter is also dedicated to the development and utilization of other piscine models of cancer. The compilation of chapters in the volume culminates into a comprehensive and definitive text on zebrafish and cancer, providing a much needed resource on the powerful attributes of the zebrafish model system.
Editors and Affiliations
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Molecular Pathology and Cancer Center, Massachusetts General Hospital, CHARLESTOWN, USA
David M. Langenau
About the editor
Dr. Langenau is an Associate Professor at Harvard Medical School and Associate Pathologist at the Massachusetts General Hospital. Dr. Langenau is joint-appointed through the Department of Pathology, the Cancer Center and the Center for Regenerative Medicine at the Massachusetts General Hospital. Dr. Langenau is also a principal faculty member at the Harvard Stem Cell Institute (HSCI) and a member of the Dana-Farber/Harvard Cancer Center. Dr. Langenau runs an active research group that focuses on uncovering mechanisms of progression and relapse in pediatic cancer. He has become a pioneer in using zebrafish to understand human cancer biology. His group has used the zebrafish model to dynamically visualize the hallmarks of cancer in live animals, to develop drug screening approaches to kill relapse-driving tumor propagating cells, and to uncover oncogenic drivers conserved in zebrafish and humans using bioinformatic approaches and cross-species comparisons.
