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Vascular Ion Channels in Physiology and Disease

  • Book
  • © 2016

Overview

Editors:
  1. Irena Levitan, PhD

    1. University of Illinois at Chicago, Chicago, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Alex M. Dopico, MD, PhD

    1. The University of Tennessee, Memphis, USA

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    You can also search for this editor in PubMed   Google Scholar

  • Presents the studies undertaken in the last decade to elucidate the roles of ion channels in different vascular diseases

  • Focuses on the roles of ion channels in vascular tissues under normal and pathological condition

  • Written by experts in the field

  • Includes supplementary material: sn.pub/extras

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xvii
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  2. Ion Channel Regulation of Vascular Tone and Blood Flow. Changes with Hypertension: Endothelial Cells

    1. Front Matter

      Pages 1-1
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    2. Endothelial Cell Ion Channel Expression and Function in Arterioles and Resistance Arteries

      • William F. Jackson
      Pages 3-36

    3. Contribution and Regulation of Calcium Channels in Endothelial Cells

      • Kwong Tai Cheng, Avia Rosenhouse-Dantsker, Asrar B. Malik
      Pages 37-62

    4. Mitochondrial Depolarization in Endothelial and Other Vascular Cells and Their Role in the Regulation of Cerebral Vascular Tone

      • David W. Busija, Ibolya Rutkai, Prasad V. Katakam
      Pages 63-78

    5. Ion Channels in Control of Blood Flow: Electrical Conduction Along Endothelium of Resistance Arteries

      • Erik J. Behringer, Steven S. Segal
      Pages 79-99

    6. Ca2+/Calmodulin-Gated Small- and Intermediate-Conductance KCa Channels in Cardiovascular Regulation: Targets for Novel Pharmacological Treatments

      • Ralf Köhler, Aida Olivan-Viguera
      Pages 101-127

  3. Ion Channel Regulation of Vascular Tone and Blood Flow. Changes with Hypertension: Smooth Muscle Cell

    1. Front Matter

      Pages 129-129
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    2. Regional Variation in Arterial Myogenic Responsiveness: Links to Potassium Channel Diversity/Function

      • Michael A. Hill, Yan Yang, Zahra Nourian, Barry D. Kyle, Kwangseok Hong, Andrew P. Braun
      Pages 131-152

    3. Ion Channel Trafficking and Control of Arterial Contractility

      • M. Dennis Leo, Jonathan H. Jaggar
      Pages 153-168

    4. Abnormalities of Vascular Ion Channels During Hypertension

      • Anup K. Srivastava, Lee Ann MacMillan-Crow, Sung W. Rhee, Nancy J. Rusch
      Pages 169-190

    5. Kv7 Potassium Channels as Therapeutic Targets in Cerebral Vasospasm

      • Bharath K. Mani, Lyubov I. Brueggemann, Sarkis Morales-Vidal, Christopher M. Loftus, Kenneth L. Byron
      Pages 191-214

    6. Lysosomal Transient Receptor Potential Mucolipin (TRPML) Channels in Vascular Regulation and Diseases

      • Fan Zhang, Pin-Lan Li
      Pages 215-229

  4. Ion Channels in the Regulation of Cell Proliferation, Remodeling, Hypertrophy and Angiogenesis

    1. Front Matter

      Pages 231-231
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    2. Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle

      • John G. McCarron, Susan Chalmers, Calum Wilson, Mairi E. Sandison
      Pages 233-254Open Access

    3. Role of Mechanosensitive TRP Channels in Abnormal Vasculature of Tumors

      • Holly C. Cappelli, Roslin J. Thoppil, Ravi K. Adapala, J. Gary Meszaros, Sailaja Paruchuri, Charles K. Thodeti
      Pages 255-273

    4. TRPC and Orai Channels in Store-Operated Calcium Entry and Vascular Remodelling

      • David J. Beech, Jing Li, Lynn McKeown, Hollie L. Appleby
      Pages 275-294

    5. Smooth Muscle Cell Ion Channels in Pulmonary Arterial Hypertension: Pathogenic Role in Pulmonary Vasoconstriction and Vascular Remodeling

      • Ramon J. Ayon, Haiyang Tang, Ruby A. Fernandez, Ayako Makino, Jason X.-J. Yuan
      Pages 295-324

  5. Ion Channel Regulation by Lipids and Channel Modifications in Metabolic Disease

    1. Front Matter

      Pages 325-325
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    2. Physiological Roles and Cholesterol Sensitivity of Endothelial Inwardly-Rectifying K+ Channels: Specific Cholesterol-Protein Interactions Through Non Annular Binding Sites

      • Irena Levitan, Sang Joon Ahn, Ibra Fancher, Avia Rosenhouse-Dantsker
      Pages 327-347
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Keywords

About this book

Ion channels are the major class of membrane proteins responsible for rapid and regulated transport of ions across biological membranes and for the generation and propagation of electrical signals in the brain, heart, and skeletal and vascular tissues. Ion channels are also known to play critical roles in regulation of cell proliferation, insulin secretion and intracellular signaling in a variety of cell types. This book focuses on the roles of ion channels in vascular tissues under normal and pathological conditions.  Vascular abnormalities are known to underlie a plethora of severe pathological conditions, such as atherosclerosis, systemic and pulmonary hypertension, coronary or cerebral vasospasm, and diabetes. In addition, misregulated angiogenesis is one of the major contributors to the development of tumors. Therefore, it is clearly imperative to obtain a better understanding of the molecular mechanisms that contribute to vascular disorders. This book will be the first comprehensive assembly of assays to present the studies that have been done during the last decade to elucidate the roles of ion channels in different vascular diseases.

Editors and Affiliations

  • University of Illinois at Chicago, Chicago, USA

    Irena Levitan, PhD

  • The University of Tennessee, Memphis, USA

    Alex M. Dopico, MD, PhD

About the editors

Alex Dopico, PhD, MD, is Chair of Pharmacology and Distinguished Professor at the University of Tennessee Health Science Center, Memphis, Tennessee.  His research interest focuses on the molecular interactions between small amphiphilic ligands, such as alcohol, and oligomeric ion channel proteins in excitable tissues, with a particular focus on cerebral artery smooth muscle.  Emphasis is put on determining site(s) of action and ion channel gating mechanisms targeted by the amphiphiles, role of membrane lipid microenvironment in regulating ligand-ion channel interaction, and consequences of such interaction on tissue and organ function.  Dr. Dopico currently holds a Merit Award from NIAAA, and also served as editor of the book Methods in Membrane Lipids published by Humana in 2007.


Irena Levitan, PhD, is a Professor of Medicine and Adjunct Professor of Pharmacology and Bioengineering at the University of Illinois at Chicago. Her current research interests focus on cholesterol regulation of ion channels and cellular biomechanics. She was named a Guyton Distinguished Lecturer by the Association of Chairs of Departments of Physiology for her quantitative and biophysical work on cholesterol modulation of ion channels and how this can affect integrated organ function. She also served as editor of the book Cholesterol Regulation of Ion Channels and Receptors, published by Wiley in 2012.

Bibliographic Information

  • Book Title: Vascular Ion Channels in Physiology and Disease

  • Editors: Irena Levitan, PhD, Alex M. Dopico, MD, PhD

  • DOI: https://doi.org/10.1007/978-3-319-29635-7

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-29633-3Published: 14 July 2016

  • Softcover ISBN: 978-3-319-80613-6Published: 30 May 2018

  • eBook ISBN: 978-3-319-29635-7Published: 06 July 2016

  • Edition Number: 1

  • Number of Pages: XVII, 431

  • Number of Illustrations: 28 b/w illustrations, 75 illustrations in colour

  • Topics: Human Physiology, Protein Science, Membrane Biology

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