Overview
- Provides an overall review of the bacterium's genetics and what DNA- and RNA-sequencing can tell us about the organism's physiology
- Reviews the interaction of H. somni with host endothelials cells and phagocytic cells
- Includes reviews on membrane proteins and lipooligasaccharides and the role these components play in the disease process
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 396)
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Table of contents (8 chapters)
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Front Matter
Keywords
About this book
This volume reviews the current understanding of the taxonomy, disease syndromes, genetics, biology, and pathogenic factors of Histophilus somni, as well as the host immune response to this pathogen. H. somni is one of the most important bacterial pathogens in cattle and other ruminants, and its virulence factors are highly conserved with Haemophilus influenzae and other members of the Pasteurellaceae. H. somni has been recognized as a major cause of thrombotic meningoencephalitis, respiratory disease syndromes, myocarditis, reproductive disease syndromes, polyarthritis, mastitis, ocular disease, and septicemia. The only known habitats of H. somni are the mucosal surfaces of ruminants, making this bacterium an opportunistic pathogen. Although it is capable of causing inflammation at systemic sites and is toxic to epithelial and phagocytic cells, the bacterium’s wide array of virulence factors act primarily as a defense against, or to escaperecognition from, host innate and adaptive immunity.
Editors and Affiliations
About the editor
Bibliographic Information
Book Title: Histophilus somni
Book Subtitle: Biology, Molecular Basis of Pathogenesis, and Host Immunity
Editors: Thomas J. Inzana
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-319-29556-5
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016
Hardcover ISBN: 978-3-319-29554-1Published: 19 April 2016
Softcover ISBN: 978-3-319-80598-6Published: 22 April 2018
eBook ISBN: 978-3-319-29556-5Published: 11 April 2016
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 160
Topics: Medical Microbiology, Veterinary Medicine/Veterinary Science, Bacteriology