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Neuro-Immuno-Gastroenterology

  • Book
  • © 2016

Overview

Editors:
  1. Cris Constantinescu

    1. Neurology, C Floor South Block, University of Nottingham, Nottingham, United Kingdom

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  2. Razvan Arsenescu

    1. Atlantic Digestive Health Institute, Morristown Medical Center, Columbus, USA

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    You can also search for this editor in PubMed   Google Scholar

  3. Violeta Arsenescu

    1. Armedica LLC, Columbus, USA

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  • Brings together gastroenterologists and neurologists with immunological interest

  • Combines basic immunology with clinical information

  • Addresses microbiological issues, providing expert information not frequently available in routine immunological literature

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Table of contents (18 chapters)

  1. Front Matter

    Pages i-xv
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  2. The Immunology of the Gastrointestinal System

    • Emily Staples, Tanya M. Monaghan, Yashwant Mahida
    Pages 1-22

  3. The Enteric Nervous System

    • Michael Constantinescu
    Pages 23-38

  4. Microbial Regulation of Gastrointestinal Immunity in Health and Disease

    • Sheila Patrick, Rebecca J. Ingram, Thamarai Schneiders, Denise C. Fitzgerald
    Pages 39-52

  5. Roles of Substance P in Gastrointestinal Functions and Neuroimmune Interactions

    • Janek Vilisaar, Razvan I. Arsenescu
    Pages 53-73

  6. Immunomodulation by Vasoactive Intestinal Polypeptide (VIP)

    • Kirsten M. Hooper, Weimin Kong, Doina Ganea
    Pages 75-96

  7. Helicobacter pylori, Experimental Autoimmune Encephalomyelitis, and Multiple Sclerosis

    • Karen Robinson, Joanna Stephens, Cris S. Constantinescu, Bruno Gran
    Pages 97-122

  8. Stress and the Gastrointestinal System

    • Bruno Bonaz
    Pages 123-156

  9. Nutrition, Macrobiotics, and the Brain’s Neuroinflammatory Response

    • Violeta Arsenescu
    Pages 157-167

  10. Guillain–Barré Syndrome and Campylobacter jejuni Enteritis

    • Nortina Shahrizaila, Nobuhiro Yuki
    Pages 169-180

  11. Gut Microbiota: A Possible Role in the Pathogenesis of Multiple Sclerosis

    • Takashi Yamamura
    Pages 181-187

  12. Intestinal Parasites and Immunomodulation in Neuroinflammatory Disease

    • Radu Tanasescu
    Pages 189-209

  13. Neurological Complications of Anti-TNF Treatments and Other Neurological Aspects of Inflammatory Bowel Disease

    • Su-Yin Lim, Cris S. Constantinescu
    Pages 211-225

  14. Intestinal Bacterial Antigens, Toxin-Induced Pathogenesis and Immune Cross-Reactivity in Neuromyelitis Optica and Multiple Sclerosis

    • Cris S. Constantinescu, I-Jun Chou
    Pages 227-236

  15. Targeting Immunomodulatory Agents to the Gut-Associated Lymphoid Tissue

    • Atheer Zgair, Jonathan Chi Man Wong, Pavel Gershkovich
    Pages 237-261

  16. The Neuroimmunology of Gluten Intolerance

    • Marios Hadjivassiliou, David S. Sanders, Daniel Aeschlimann
    Pages 263-285

  17. The Neurology of Autoimmune Pernicious Anaemia (Subacute Combined Degeneration)

    • Laura Edwards
    Pages 287-307

  18. The Impact of Multiple Sclerosis on Gastrointestinal System Function

    • David J. Levinthal, Klaus Bielefeldt
    Pages 309-326

  19. The Neurology of Whipple’s Disease

    • Ribal Bassil, Carolina Ionete
    Pages 327-337
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Keywords

About this book

This book addresses important issues regarding the interaction between the nervous system, the immune system, and the digestive system. Gut flora has a profound influence on the shaping of the immune response, not only in the gastrointestinal system but also in the nervous system. Fascinatingly, manipulation of intestinal immune responses can be used to modulate neurological disease. Conversely, the nervous system and the psyche have significant effects on the functioning of the gut and liver. 

After introductory chapters on the neurology, the immunology and microbiology of the gut, the effects of the gut immune system and gut flora and its manipulation on neurological disease are discussed, followed by molecular mimicry and immune tolerance in neuroimmune diseases. Additionally, several chapters deal with gastrointestinal manifestations of neurological diseases. 

Neuro-Immuno-Gastroenterology is aimed at neurologists, gastroenterologists, and immunologists.

Reviews

“This book is designed to increase the understanding of the complex relationship between the gut flora, the nervous system, and the immune system, a topic that is often poorly understood and underappreciated in clinical medicine. … book is intended for practicing clinicians in the fields of gastroenterology, neurology, and immunology, written by authors who are experts in their fields. … a useful contribution to the field, as many books aiming to cover a wealth of information lack these specific topics.” (Nicole E. Pisapia, Doody's Book Reviews, March, 2017)

Editors and Affiliations

  • Neurology, C Floor South Block, University of Nottingham, Nottingham, United Kingdom

    Cris Constantinescu

  • Atlantic Digestive Health Institute, Morristown Medical Center, Columbus, USA

    Razvan Arsenescu

  • Armedica LLC, Columbus, USA

    Violeta Arsenescu

About the editors

Cris S Constantinescu graduated from Boston University School of Medicine and completed a PhD in Immunology at the University of Pennsylvania. He completed training in Neurology and Fellowship in Neuroimmunology at the University of Pennsylvania. His main research interest is in the immunopathogenesis and the immunotherapeutics of multiple sclerosis, and in neuroimmune interactions. He is currently Professor and Chair of Clinical Neurology in the Division of Clinical Neuroscience at the University of Nottingham in the United Kingdom.

Razvan Arsenescu received his Ph.D. degree from The University of Kentucky College of Medicine – Microbiology, Immunology & Molecular Genetics – and his medical degree from The University of Medicine and Pharmacy Tg. Mures, Romania. Currently, he is the Chief of Atlantic Digestive Health Institute and Director of Atlantic Inflammatory Bowel Diseases Center in Morristown, NJ, USA.

Violeta Arsenescu received her Ph.D. degree from The University of Kentucky College of Medicine – Graduate Center for Nutritional Sciences, and her medical degree from The University of Medicine and Pharmacy Tg. Mures, Romania. Currently, she is the Director of Medical Nutrition Consulting at Armedica LLC.

Bibliographic Information

  • Book Title: Neuro-Immuno-Gastroenterology

  • Editors: Cris Constantinescu, Razvan Arsenescu, Violeta Arsenescu

  • DOI: https://doi.org/10.1007/978-3-319-28609-9

  • Publisher: Springer Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-28607-5Published: 02 June 2016

  • Softcover ISBN: 978-3-319-80387-6Published: 30 May 2018

  • eBook ISBN: 978-3-319-28609-9Published: 24 May 2016

  • Edition Number: 1

  • Number of Pages: XV, 337

  • Number of Illustrations: 7 b/w illustrations, 34 illustrations in colour

  • Topics: Neurology, Gastroenterology, Immunology

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