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Calcium Entry Pathways in Non-excitable Cells

  • Book
  • © 2016

Overview

Editors:
  1. Juan A. Rosado

    1. Depto. Fisiología, University of Extremadura, Cáceres, Spain

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  • Provides an extensive overview of the mechanisms underlying calcium entry in non-excitable cells
  • Includes relevant background information, critical analysis of the current observations and directions for future research
  • Written in a concise manner by leading scientists in the field

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 898)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-x
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  2. Store-Operated Calcium Entry

    1. Front Matter

      Pages 1-1
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    2. Historical Overview of Store-Operated Ca2+ Entry

      • Letizia Albarran, Jose J. Lopez, Ginés M. Salido, Juan A. Rosado
      Pages 3-24

    3. The STIM1: Orai Interaction

      • Irene Frischauf, Marc Fahrner, Isaac Jardín, Christoph Romanin
      Pages 25-46

    4. The TRPCs, Orais and STIMs in ER/PM Junctions

      • Dong Min Shin, Aran Son, Seonghee Park, Min Seuk Kim, Malini Ahuja, Shmuel Muallem
      Pages 47-66

    5. TRP-Na+/Ca2+ Exchanger Coupling

      • Alan G. S. Harper, Stewart O. Sage
      Pages 67-85

    6. Role of TRPC Channels in Store-Operated Calcium Entry

      • Hwei Ling Ong, Lorena Brito de Souza, Indu S. Ambudkar
      Pages 87-109

    7. Phospholipase A2 as a Molecular Determinant of Store-Operated Calcium Entry

      • Tarik Smani, Alejandro Domínguez-Rodriguez, Paula Callejo-García, Juan A. Rosado, Javier Avila-Medina
      Pages 111-131

    8. Extracellular Calcium Has Multiple Targets to Control Cell Proliferation

      • Thierry Capiod
      Pages 133-156

    9. Regulation of Platelet Function by Orai, STIM and TRP

      • Alejandro Berna-Erro, Isaac Jardín, Tarik Smani, Juan A. Rosado
      Pages 157-181

  3. Non-capacitative Ca2+ Entry Pathways

    1. Front Matter

      Pages 183-183
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    2. On the Roles of the Transient Receptor Potential Canonical 3 (TRPC3) Channel in Endothelium and Macrophages: Implications in Atherosclerosis

      • Guillermo Vazquez, Sumeet Solanki, Prabhatachandra Dube, Kathryn Smedlund, Prince Ampem
      Pages 185-199

    3. Second Messenger-Operated Calcium Entry Through TRPC6

      • Alexandre Bouron, Sylvain Chauvet, Stuart Dryer, Juan A. Rosado
      Pages 201-249

    4. Transient Receptor Potential Canonical 7 (TRPC7), a Calcium (Ca2+) Permeable Non-selective Cation Channel

      • Xuexin Zhang, Amy M. Spinelli, Timothy Masiello, Mohamed Trebak
      Pages 251-264

    5. Calcium Entry Through Thermosensory Channels

      • Francisco J. Taberner, Isabel Devesa, Antonio Ferrer-Montiel
      Pages 265-304

    6. Calcium Signalling through Ligand-Gated Ion Channels such as P2X1 Receptors in the Platelet and other Non-Excitable Cells

      • Martyn P. Mahaut-Smith, Kirk A. Taylor, Richard J. Evans
      Pages 305-329

  4. Role of Cellular Microdomains and Organelles in Calcium Entry

    1. Front Matter

      Pages 331-331
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    2. The Calcium Entry-Calcium Refilling Coupling

      • Ziane Elaib, Francois Saller, Regis Bobe
      Pages 333-352

    3. Microdomains Associated to Lipid Rafts

      • Jonathan Pacheco, Josué O. Ramírez-Jarquín, Luis Vaca
      Pages 353-378

    4. Role of Scaffolding Proteins in the Regulation of TRPC-Dependent Calcium Entry

      • Bruno Constantin
      Pages 379-403
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Keywords

About this book

Calcium entry pathways in non-excitable cells presents a concise synthesis of thoughtfully selected topics covering from the different calcium entry mechanisms in non-excitable cells to the cellular microdomains and organelles regulating the calcium entry process. Particular attention is given to the fascinating group of ion channels involved in different calcium entry pathways as well as the emerging role of these channels in human disease. Calcium entry is an essential mechanism for cellular function in non-excitable cells. In general, two main calcium entry pathways exist in non-excitable cells: one pathway, named store-operated calcium entry (SOCE) requires store depletion and the second pathway is regulated by receptor occupation, but independently on calcium store depletion. The search for the molecular components of calcium entry has identified the stromal interaction molecule 1 (STIM1), as the calcium sensor of the intracellular calcium stores, and Orai as well as TRP channelsas the calcium-permeable channels located in the plasma membrane. The location, interactions and function of these channels are finely regulated by a number of scaffolding proteins, membrane microdomains and cellular organelles that fine tune the amount of calcium entering the cell. Cutting-edge and user-friendly, this volume presents relevant background information, critical analysis of the current observations and directions for future research. The book is intended for basic scientists specializing in cellular biology or ion transport, as well as for biomedical researchers.

Editors and Affiliations

  • Depto. Fisiología, University of Extremadura, Cáceres, Spain

    Juan A. Rosado

Bibliographic Information

  • Book Title: Calcium Entry Pathways in Non-excitable Cells

  • Editors: Juan A. Rosado

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-26974-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Hardcover ISBN: 978-3-319-26972-6Published: 17 May 2016

  • Softcover ISBN: 978-3-319-80050-9Published: 26 May 2018

  • eBook ISBN: 978-3-319-26974-0Published: 09 May 2016

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 471

  • Number of Illustrations: 2 b/w illustrations, 34 illustrations in colour

  • Topics: Cell Biology, Human Physiology

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