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B Cell Receptor Signaling

  • Book
  • © 2016

Overview

Editors:
  1. Tomohiro Kurosaki

    1. WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

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    You can also search for this editor in PubMed   Google Scholar

  2. Jürgen Wienands

    1. Cellular and Molecular Immunology, Georg August University Goettingen, Göttingen, Germany

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    You can also search for this editor in PubMed   Google Scholar

  • Discusses current models of how the B cell antigen receptor becomes activated
  • Focusses on the elucidation of intracellular B cell receptor signaling pathways
  • Describes modulation of B cell activation by coreceptors and under disease conditions
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 393)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-x
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  2. Assembly and Function of the Precursor B-Cell Receptor

    • Rudolf Übelhart, Markus Werner, Hassan Jumaa
    Pages 3-25

  3. Receptor Dissociation and B-Cell Activation

    • Jianying Yang, Michael Reth
    Pages 27-43

  4. Molecular Mechanisms of B Cell Antigen Gathering and Endocytosis

    • Robbert Hoogeboom, Pavel Tolar
    Pages 45-63

  5. BTK Signaling in B Cell Differentiation and Autoimmunity

    • Odilia B. J. Corneth, Roel G. J. Klein Wolterink, Rudi W. Hendriks
    Pages 67-105

  6. The Memory Function of the B Cell Antigen Receptor

    • Jürgen Wienands, Niklas Engels
    Pages 107-121

  7. PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

    • Klaus Okkenhaug, Jan A. Burger
    Pages 123-142Open Access

  8. Role of Calcium Signaling in B Cell Activation and Biology

    • Yoshihiro Baba, Tomohiro Kurosaki
    Pages 143-174

  9. Roles of the NF-κB Pathway in B-Lymphocyte Biology

    • Yoshiteru Sasaki, Kazuhiro Iwai
    Pages 177-209

  10. MAP Kinase Cascades in Antigen Receptor Signaling and Physiology

    • Tomoharu Yasuda
    Pages 211-231

  11. Erratum to: PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL)

    • Klaus Okkenhaug, Jan A. Burger
    Pages E1-E1
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Keywords

About this book

This volume details our current understanding of the architecture and signaling capabilities of the B cell antigen receptor (BCR) in health and disease. The first chapters review new insights into the assembly of BCR components and their organization on the cell surface. Subsequent contributions focus on the molecular interactions that connect the BCR with major intracellular signaling pathways such as Ca2+ mobilization, membrane phospholipid metabolism, nuclear translocation of NF-kB or the activation of Bruton’s Tyrosine Kinase and MAP kinases. These elements orchestrate cytoplasmic and nuclear responses as well as cytoskeleton dynamics for antigen internalization. Furthermore, a key mechanism of how B cells remember their cognate antigen is discussed in detail. Altogether, the discoveries presented provide a better understanding of B cell biology and help to explain some B cell-mediated pathogenicities, like autoimmune phenomena or the formation of B cell tumors, whilealso paving the way for eventually combating these diseases.

Editors and Affiliations

  • WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

    Tomohiro Kurosaki

  • Cellular and Molecular Immunology, Georg August University Goettingen, Göttingen, Germany

    Jürgen Wienands

About the editors

Tomohiro Kurosaki, MD, PhD, is a professor at WPI Immunology Frontier Research Center at Osaka University, Japan Jürgen Wienands, PhD, is a professor of Cellular and Molecular Immunology at the University of Göttingen, Germany

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