Overview
- Covers the great discoveries of protein crystallography of the 20th century, as told by one of the protagonists
- Explains the unique selectivity of proteins in the binding of small molecules
- Addresses the most important questions about protein binding sites
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Table of contents (5 chapters)
Keywords
About this book
Reviews
“This study is quite probably the inspiration behind ‘The discreet charm’, which is a personal, and passionate story of how proteins interact with other chemical moieties, be it organic molecules or other proteins. … The book is well illustrated, both with copies of original figures from the referenced bibliography, as well as schematic structure figures prepared using Protein Data Bank (PDB) entries. … the book is a pleasure to read.” (Zygmunt Derewenda, Crystallography Reviews, May, 2016)
Authors and Affiliations
About the author
Joseph Yariv graduated from The Hebrew University in Jerusalem with a Ph.D. in biochemistry. After postdoctoral studies at the Sloan Kettering Institute and Columbia University in New York, USA he joined the department of biophysics of The Weizmann Institute of Science in Rehovot, Israel where he worked until his retirement in the position of Senior Scientist. His work dealt with protein isolation, crystallization and structure solution. He was the first to label a methionine in the active-site of b-galacosidase of E. coli. He produced crystals of concanavalin A complexes with methyl-glucoside and with methyl-mannoside and participated in solving the structure of this protein binding-site for saccharides. He collaborated with physicists at The Hebrew University in Jerusalem in studying by Mossbauer Spectroscopy the state of iron in E. coli that led to the isolation of bacterioferritin, the first ferritin-like molecule to be found in bacteria and named as such, and solutionof its structure.
Bibliographic Information
Book Title: The Discreet Charm of Protein Binding Sites
Authors: Joseph Yariv
DOI: https://doi.org/10.1007/978-3-319-24996-4
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-24994-0Published: 18 December 2015
Softcover ISBN: 978-3-319-79717-5Published: 27 March 2019
eBook ISBN: 978-3-319-24996-4Published: 09 December 2015
Edition Number: 1
Number of Pages: XIII, 60
Number of Illustrations: 6 b/w illustrations, 10 illustrations in colour
Topics: Protein-Ligand Interactions, Biological and Medical Physics, Biophysics, Bioorganic Chemistry, Receptors, Crystallography and Scattering Methods, Protein Science