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  • © 2016

Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management

  • Provides a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans
  • Addresses statistics and epidemiology of lung cancer, along with the incidence of lung cancer in non-smokers
  • Evaluates the state of current therapies–immune, targeted therapies against EGFR TKIs, KRAS, ALK and the associated challenges, especially resistance mechanisms

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 890)

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Table of contents (11 chapters)

  1. Front Matter

    Pages i-x
  2. Lung Cancer Genomics in the Era of Accelerated Targeted Drug Development

    • Priyanga Wijesinghe, Aliccia Bollig-Fischer
    Pages 1-23
  3. Emerging Biomarkers in Personalized Therapy of Lung Cancer

    • Philip T. Cagle, Kirtee Raparia, Bryce P. Portier
    Pages 25-36
  4. The Role of Cancer Stem Cells in Recurrent and Drug-Resistant Lung Cancer

    • Raagini Suresh, Shadan Ali, Aamir Ahmad, Philip A. Philip, Fazlul H. Sarkar
    Pages 57-74
  5. The Microenvironment of Lung Cancer and Therapeutic Implications

    • Vivek Mittal, Tina El Rayes, Navneet Narula, Timothy E. McGraw, Nasser K Altorki, Mary Helen Barcellos-Hoff
    Pages 75-110
  6. Next-Generation Sequencing and Applications to the Diagnosis and Treatment of Lung Cancer

    • Kristina M. Kruglyak, Erick Lin, Frank S. Ong
    Pages 123-136
  7. Nanomedicine for Treatment of Lung Cancer

    • Sajid Hussain
    Pages 137-147
  8. Personalized Therapy of Small Cell Lung Cancer

    • Bryan J. Schneider, Gregory P. Kalemkerian
    Pages 149-174
  9. Personalized Radiation Therapy (PRT) for Lung Cancer

    • Jian-Yue Jin, Feng-Ming (Spring) Kong
    Pages 175-202
  10. Back Matter

    Pages 223-231

About this book

This, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and the promise of epigenetics and next-generation sequencing for the advancements towards personalized therapy of lung cancer patients. With chapters on state-of-the-art therapies and technologies written by leading experts working to develop novel companion diagnosis tools for the personalized treatment of lung cancer patients, this volume brings readers up-to-date by presenting the current knowledge on the efforts to make personalized management of lung cancer patients a reality. 

Editors and Affiliations

  • Wayne State University, Karmanos Cancer Institute, Detroit, USA

    Aamir Ahmad

  • Karamanos Cancer Institute, Wayne State University, Detroit, USA

    Shirish M. Gadgeel

About the editors

Aamir Ahmad, PhD, is a Scientist at the Wayne State University School of Medicine Department of Pathology and the Karmanos Cancer Institute, with over 100 published scientific articles in peer-reviewed journals and many book chapters. He has been a member of leading cancer organizations such as American Association for Cancer Research (AACR, Philadelphia, USA) and International Union against Cancer (UICC, Geneva, Switzerland). In addition to serving as a reviewer for a number of peer-reviewed scientific journals, he is currently a Section Editor for the journal PLoS ONE responsible for policy drafts for the journal and identification and management of special issues. In addition to the current volume, Dr. Ahmad has worked with Springer to edit two more volumes, Breast Cancer Metastasis and Drug Resistance and Lung Cancer and Personalized Medicine: Current Knowledge and Therapies.

Shirish M. Gadgeel is a Professor in the Department of Oncology at Karmanos Cancer Institute/Wayne State University in Detroit. He is also the co-leader of the Molecular Therapeutics Program of Karmanos Cancer Institute and the Leader of the Multidisciplinary Thoracic Oncology team. He is

a member of several professional societies, including the American Society of Clinical Oncology and the International Association for the Study of Lung Cancer. He currently serves on the Editorial Board of the journals Cancer and Clinical Lung Cancer. Dr. Gadgeel has been and is a Principal Investigator of several trials focused on the treatment of Lung Cancer. He has over 80 peer reviewed publications.  

Bibliographic Information

  • Book Title: Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management

  • Editors: Aamir Ahmad, Shirish M. Gadgeel

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-24932-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Hardcover ISBN: 978-3-319-24931-5Published: 18 January 2016

  • Softcover ISBN: 978-3-319-79702-1Published: 30 March 2018

  • eBook ISBN: 978-3-319-24932-2Published: 24 December 2015

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 231

  • Number of Illustrations: 1 b/w illustrations, 21 illustrations in colour

  • Topics: Cancer Research

Buy it now

Buying options

eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access