Editors:
- First book dedicated to Epigenetics of Infectious Disease
- Deals with two major classes of infectious pathogens, i.e. bacteria and viruses
- Comprehensive review of epigenetic reprogramming by bacteria and viruses
Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 879)
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Table of contents (6 chapters)
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Front Matter
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Back Matter
About this book
Epigenetic modification of cellular genomes is a fascinating means of regulating tissue- and cell type-specific gene expression in all developmental stages of the life of an organism. Carefully orchestrated processes, such as DNA methylation and a plenitude of specific histone modifications secure the faithful transmission of gene expression patterns to progeny cells. Upon chronic infection, the epigenetic cellular balance can become disrupted and, in the long run, through the epigenetic reprogramming of host cell genomes, contribute to the malignant conversion of formerly healthy cells, in many cases preceded by the establishment of an epigenetic field of cancerization. The present volume undertakes to highlight the interactions of infectious pathogens and their effector molecules with the epigenetic regulatory machinery of the cell. Clearly, the recent take-off of epigenetics research did not leave Research on Infectious Diseases and Infection-Associated Cancer untouched. This resulted in a great many of clinically relevant data on understanding the molecular mechanisms of chronic infectious disease. Infectious pathogen- and disease-specific epigenetic alterations are already being used for the early detection of malignant disease and for the prediction of chemotherapy resistance or response to treatment.
Editors and Affiliations
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University of Szeged, Szeged, Hungary
Janos Minarovits
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University of Regensburg, Regensburg, Germany
Hans Helmut Niller
Bibliographic Information
Book Title: Patho-Epigenetics of Infectious Disease
Editors: Janos Minarovits, Hans Helmut Niller
Series Title: Advances in Experimental Medicine and Biology
DOI: https://doi.org/10.1007/978-3-319-24738-0
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016
Hardcover ISBN: 978-3-319-24736-6Published: 18 December 2015
Softcover ISBN: 978-3-319-79669-7Published: 27 March 2019
eBook ISBN: 978-3-319-24738-0Published: 11 December 2015
Series ISSN: 0065-2598
Series E-ISSN: 2214-8019
Edition Number: 1
Number of Pages: XV, 137
Number of Illustrations: 8 illustrations in colour
Topics: Microbial Genetics and Genomics, Infectious Diseases, Molecular Medicine, Virology, Medical Microbiology