Physical Models of Cell Motility

1. Front Matter

   Pages i-ix

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2. Macroscopic Model of Substrate-Based Cell Motility

   • Falko Ziebert, Jakob Löber, Igor S. Aranson

   Pages 1-67

3. Cell Crawling Driven by Spontaneous Actin Polymerization Waves

   • Karsten Kruse

   Pages 69-93

4. A Modular View of the Signaling System Regulating Chemotaxis

   • Pablo A. Iglesias

   Pages 95-134

5. Cell Locomotion in One Dimension

   • Pierre Recho, Lev Truskinovsky

   Pages 135-197

6. Back Matter

   Pages 199-201

   PDF

This book surveys the most recent advances in physics-inspired cell movement models. This synergetic, cross-disciplinary effort to increase the fidelity of computational algorithms will lead to a better understanding of the complex biomechanics of cell movement, and stimulate progress in research on related active matter systems, from suspensions of bacteria and synthetic swimmers to cell tissues and cytoskeleton.Cell motility and collective motion are among the most important themes in biology and statistical physics of out-of-equilibrium systems, and crucial for morphogenesis, wound healing, and immune response in eukaryotic organisms. It is also relevant for the development of effective treatment strategies for diseases such as cancer, and for the design of bioactive surfaces for cell sorting and manipulation. Substrate-based cell motility is, however, a very complex process as regulatory pathways and physical force generation mechanisms are intertwined. To understand the interplay between adhesion, force generation and motility, an abundance of computational models have been proposed in recent years, from finite element to immerse interface methods and phase field approaches.This book is primarily written for physicists, mathematical biologists and biomedical engineers working in this rapidly expanding field, and ca
n serve as supplementary reading for advanced graduate courses in biophysics and mathematical biology. The e-book incorporates experimental and computer animations illustrating various aspects of cell movement.

• Adhesion and Cell Motility
• Adhesive Substrate
• Cell Motility Models
• Cell Movement Biomechanics
• Chemical Waves and Cell Motility
• Cytoskeletal Waves
• Eukaryotic Cell Motility
• Force Generation and Cell Motility
• Phase-field Methods Cell Motility
• Substrate-based Cell Motility

• Argonne National Laboratory, Argonne, USA

  Igor S. Aranson

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