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Long Non-coding RNAs in Human Disease

  • Book
  • © 2016

Overview

Editors:
  1. Kevin V. Morris

    1. City of Hope - Beckman Research Institute, Center for Gene Therapy City of Hope-Beckman Research Institute, Duarte, USA

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  • Summarizes the tremendous
  • progress made within the last decade in understanding the roles of lncRNA in
  • Bridges the divide between inferring lncRNA mechanisms and targeting lncRNAs by means of rational therapeutics
  • Stresses the vital role of lncRNA disease mechanisms for a necessary and profound reassessment of Genome-Wide Association studies in the new era of personalized medicine
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 394)

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Table of contents (10 chapters)

  1. Front Matter

    Pages i-viii
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  2. Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and Its Implications in Disease Conditions

    • John Lalith Charles Richard, Yuya Ogawa
    Pages 1-27

  3. Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease

    • Francesca Aguilo, Serena Di Cecilia, Martin J. Walsh
    Pages 29-39

  4. Form and Function of Exosome-Associated Long Non-coding RNAs in Cancer

    • Chris Hewson, Kevin V. Morris
    Pages 41-56

  5. Long Noncoding RNAs in Lung Cancer

    • Anna Roth, Sven Diederichs
    Pages 57-110

  6. Pseudogene-Expressed RNAs: Emerging Roles in Gene Regulation and Disease

    • Dan Grandér, Per Johnsson
    Pages 111-126

  7. Functional Long Non-coding RNAs in Vascular Smooth Muscle Cells

    • Amy Leung, Kenneth Stapleton, Rama Natarajan
    Pages 127-141

  8. Long Noncoding RNAs as Targets and Regulators of Nuclear Receptors

    • Charles E. Foulds, Anil K. Panigrahi, Cristian Coarfa, Rainer B. Lanz, Bert W. O’Malley
    Pages 143-176

  9. Noncoding Transcriptional Landscape in Human Aging

    • Marina C. Costa, Ana Lúcia Leitão, Francisco J. Enguita
    Pages 177-202

  10. lncRNAs in Stress Response

    • Saba Valadkhan, Alberto Valencia-Hipólito
    Pages 203-236

  11. Expression Specificity of Disease-Associated lncRNAs: Toward Personalized Medicine

    • Quan Nguyen, Piero Carninci
    Pages 237-258

  12. Back Matter

    Pages 259-262
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Keywords

About this book

This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.

Editors and Affiliations

  • City of Hope - Beckman Research Institute, Center for Gene Therapy City of Hope-Beckman Research Institute, Duarte, USA

    Kevin V. Morris

About the editor

Kevin Morris is an Associate Professor at the Department of Molecular and Experimental Medicine, The Scripps Research Institute in La Jolla, CA, USA. The responsible series editor is Peter K. Vogt, The Scripps Research Institute in La Jolla, CA, USA.

Bibliographic Information

  • Book Title: Long Non-coding RNAs in Human Disease

  • Editors: Kevin V. Morris

  • Series Title: Current Topics in Microbiology and Immunology

  • DOI: https://doi.org/10.1007/978-3-319-23907-1

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2016

  • Hardcover ISBN: 978-3-319-23906-4Due: 22 April 2016

  • Softcover ISBN: 978-3-319-79551-5Published: 22 April 2018

  • eBook ISBN: 978-3-319-23907-1Published: 13 April 2016

  • Series ISSN: 0070-217X

  • Series E-ISSN: 2196-9965

  • Edition Number: 1

  • Number of Pages: VIII, 262

  • Topics: Cancer Research, Immunology, Human Genetics

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