Hemodiafiltration

1. Front Matter

   Pages i-xiv

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2. History and Current Status of Online Haemodiafiltration

   • Bernard Canaud, Ingrid Ledebo

   Pages 1-16

3. Technical Aspects

   1. Front Matter

      Pages 17-17

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   2. Convective Techniques

      • Luciano A. Pedrini, Simona Zerbi

      Pages 19-39

   3. Water Treatment and Safety Requirements

      • Richard A. Ward, James E. Tattersall

      Pages 41-55

   4. Dialyzers for Hemodiafiltraion

      • Claudio Ronco, Sara Samoni, Silvia De Rosa

      Pages 57-68

4. Hemodiafiltration Equipment

   1. Front Matter

      Pages 69-69

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   2. Baxter Online Hemodiafiltration Systems

      • Jan Sternby, Anders Felding, Lars-Göran Nilsson

      Pages 71-78

   3. Dialog+: B. Braun Hemodiafiltration System

      • Marten Kelm, Björn Bröker, Claudia Barth

      Pages 79-86

   4. Online Hemodiafiltration Systems by Bellco: Flexya

      • Andrea Fiorenzi

      Pages 87-94

   5. Online Hemodiafiltration by Fresenius Medical Care

      • Bernard Canaud, Pascal Kopperschmidt, Reiner Spickermann, Emanuele Gatti

      Pages 95-102

   6. Nikkiso Hemodiafiltration Equipment

      • Daisuke Toshigami, Uwe Rogalla, Yoshiro Ueda

      Pages 103-110

   7. Nipro Online Hemodiafiltration System: Surdial™-X

      • Matteo Lavezzini

      Pages 111-118

5. Effects of Hemodiafiltration on Various Biomarkers

   1. Front Matter

      Pages 119-119

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   2. Effects of Convective Dialysis Techniques on Electrolytes and Mineral Metabolism

      • Andrew Davenport, Marc Vervloet

      Pages 121-135

   3. Effects of Haemodiafiltration of Anemia Control

      • Lucia Del Vecchio, Neelke C. van der Weerd, Francesco Locatelli

      Pages 137-151

   4. Effects of Hemodiafiltration of Inflammation and Oxidative Stress

      • Andrew Davenport

      Pages 153-163

   5. Effects on the Removal of Uremic Toxins

      • Griet L. R. L. Glorieux, Detlef H. Krieter

      Pages 165-182

   6. Effects of Hemodiafiltration on Platelets and Coagulation

      • Menso J. Nubé, Auguste Sturk

      Pages 183-195

6. Clinical Aspects of Hemodiafiltration

   1. Front Matter

      Pages 197-197

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This book gives a complete description of online hemodiafiltration, in five sections. It is unique in the systematic and complete way in which hemodiafiltration is described. Each chapter is completed by a point-to-point summary of essential information, in a separate text box. Part of the book is dedicated to the theoretical background of convective clearance. In this part, safety issues and quality control is reviewed (especially on the quality of water for dialysis and substitution fluid), as well as equipment (both dialyzers and machines) with which this treatment can be performed. As recently the results of several randomized controlled trials were available, the effect of hemodiafiltration on hard clinical end points (mortality and morbidity) is discussed in detail. This has not been done before, as the most recent book/journal on hemodiafiltration was published in 2011, before the results of the 3 randomized controlled trials were published. Furthermore, the methodological quality of the trials is discussed by an expert, in order to help the readers in their judgment of the trials Part of the book concentrates on the effect of the treatment on several biomarkers and uremic toxins. Several clinically relevant issues is discussed separately, such as the prescription of anticoagulation during the treatment, drug prescription and clearance for patients treated with hemodiafiltration, and hemodynamic stability. Finally, a practical guide on how to perform the treatment is provided. In this unique section, seemingly simple but important details of hemodiafiltration-treatment is discussed, such as the importance of needle size for blood flow rates, the difference between filtration fraction and substitution ratio, the different targets that can be set and how to reach them. As most literature is mainly focused on theoretical issues, this unique feature really will help the field to perform hemodiafiltration, and answer practical questions.

• Convective Clearance
• Hemodialfiltration
• Hemodialysis
• Technical Guide
• Uremic Clearance

“It is designed to introduce hemodiafiltration to healthcare professionals and those involved in the dialysis industry, and to discuss how current dialysis therapies have not provided improved survival benefits to patients. … It is aimed at healthcare professionals, regulating bodies, the dialysis industry, patients, and the insurance industry. … This book is very important to modern day nephrology. … an excellent introduction to the modality, its potential future use in treating the dialysis population, and potential for improved patient survival.” (Juan-Carlos Aycnena, Doody's Book Reviews, May, 2016)

• Department of Nephrology, VU University Medical Centre, Amsterdam, The Netherlands

  Menso J. Nubé

• Department of Nephrology, VU University Medical Center, Amsterdam, The Netherlands

  Muriel P.C. Grooteman

• Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands

  Peter J. Blankestijn

Menso J. Nubé is professor at the department of Nephrology at the VU Vrije Universiteit Medical Center (VUmc) in Amsterdam, the Netherlands. He is involved in research on biocompatibility of hemodialysis treatment and hemodiafiltration since 1993, and an expert in cardiovascular disease in patients with kidney disease. 

Muriel P.C. Grooteman is internist/nephrologist at the department of Nephrology at the VU Vrije Universiteit Medical Center (VUmc) in Amsterdam. She is involved in research on biocompatibility of hemodialysis treatment and hemodiafiltration since 1993, and a specialist in cardiovascular complications of dialysis treatment. 

Peter J. Blankestijn is internist/nephrologist and associate professor at the department of Nephrology at the University Medical Center Utrecht (UMCU) in Utrecht, the Netherlands. He is an expert in autonomic dysregulation in patients with end stage kidney disease, and involved in research on hemodialysis and hemodiafiltration since the 90s. 

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