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Epstein Barr Virus Volume 2

One Herpes Virus: Many Diseases

  • Book
  • © 2015

Overview

Editors:
  1. Christian Münz

    1. Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

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  • Historical reminiscence of Professor Sir Anthony Epstein on the discovery of EBV 50 years ago
  • 32 comprehensive chapters on EBV virology, tumorigenesis and immune control
  • Newest insights on EBV strain variation, the recombinant EBV system and in vivo models of infection
  • Comprehensive account of EBV associated diseases, including autoimmune diseases
  • Update on EBV specific therapies including adoptive T cell transfer and new vaccine formulations
  • Includes supplementary material: sn.pub/extras

Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 391)

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Table of contents (17 chapters)

  1. Front Matter

    Pages i-vi
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  2. EBV Latency

    1. Front Matter

      Pages 1-1
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    2. EBNA1

      • Lori Frappier
      Pages 3-34

    3. EBNA2 and Its Coactivator EBNA-LP

      • Bettina Kempkes, Paul D. Ling
      Pages 35-59

    4. The EBNA3 Family: Two Oncoproteins and a Tumour Suppressor that Are Central to the Biology of EBV in B Cells

      • Martin J. Allday, Quentin Bazot, Robert E. White
      Pages 61-117

    5. The Latent Membrane Protein 1 (LMP1)

      • Arnd Kieser, Kai R. Sterz
      Pages 119-149

    6. Latent Membrane Protein 2 (LMP2)

      • Osman Cen, Richard Longnecker
      Pages 151-180

    7. EBV Noncoding RNAs

      • Rebecca L. Skalsky, Bryan R. Cullen
      Pages 181-217

  3. Lytic EBV Infection

    1. Front Matter

      Pages 219-219
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    2. Viral Entry

      • Liudmila S. Chesnokova, Ru Jiang, Lindsey M. Hutt-Fletcher
      Pages 221-235

    3. Epstein-Barr Virus Lytic Cycle Reactivation

      • Jessica McKenzie, Ayman El-Guindy
      Pages 237-261

  4. Immune Responses to EBV

    1. Front Matter

      Pages 263-263
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    2. Innate Immune Recognition of EBV

      • Anna Lünemann, Martin Rowe, David Nadal
      Pages 265-287

    3. Epstein-Barr Virus-Specific Humoral Immune Responses in Health and Disease

      • Jaap M. Middeldorp
      Pages 289-323

    4. T-Cell Responses to EBV

      • Andrew D. Hislop, Graham S. Taylor
      Pages 325-353

    5. Immune Evasion by Epstein-Barr Virus

      • Maaike E. Ressing, Michiel van Gent, Anna M. Gram, Marjolein J. G. Hooykaas, Sytse J. Piersma, Emmanuel J. H. J. Wiertz
      Pages 355-381

  5. Animal Models of EBV Infection

    1. Front Matter

      Pages 383-383
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    2. Non-human Primate Lymphocryptoviruses: Past, Present, and Future

      • Janine Mühe, Fred Wang
      Pages 385-405

    3. EBV Infection of Mice with Reconstituted Human Immune System Components

      • Christian Münz
      Pages 407-423

  6. Therapy of EBV Associated Diseases

    1. Front Matter

      Pages 425-425
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Keywords

About this book

Epstein Barr virus (EBV) was discovered as the first human tumor virus around 50 years ago. Since its discovery in Burkitt’s lymphoma it has been associated with various other malignancies, infectious mononucleosis and even autoimmune diseases. The two book volumes on EBV summarize the first 50 years of research on this tumor virus, starting with historical perspectives on discovery, oncogenicity and immune control, reviewing the role that the virus plays in the various associated diseases and concluding with a discussion on how the immune system keeps persistent EBV infection under control in healthy EBV carriers and can be used to treat EBV associated diseases. The respective 32 chapters are written by international experts from three continents for health care providers, biomedical researchers and patients that are affected by EBV. The assembled knowledge should help to understand EBV associated diseases better and to develop EBV specific vaccination in the near future.

Editors and Affiliations

  • Institute of Experimental Immunology, University of Zürich, Zürich, Switzerland

    Christian Münz

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