The Serpin Family

1. Front Matter

   Pages i-viii

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2. The Human SERPIN Repertoire and the Evolution of 14q32.1 and 18q21.3 Gene Clusters

   • Susana Seixas

   Pages 1-14

3. Serpins in Plants

   • Maja Cohen, Thomas H. Roberts, Robert Fluhr

   Pages 15-28

4. Peptides as Modulators of Serpin Action

   • Cathleen Jendrny, Annette G. Beck-Sickinger

   Pages 29-45

5. Genomic and Functional Studies of Serpins from Basal Vertebrates Provide Insight into the Evolution of Haemostatic Control and Blood Pressure Regulation

   • Hermann Ragg, Yunjie Wang

   Pages 47-57

6. Regulation of Neutrophil Serine Proteases by Intracellular Serpins

   • Charaf Benarafa

   Pages 59-76

7. SerpinB1: A Global Regulator of Neutrophil Homeostasis

   • Lifei Hou, Kalamo Farley, Eileen Remold-O’Donnell

   Pages 77-91

8. Serpins in T Lymphocyte Immunity and Blood Development

   • Philip G. Ashton-Rickardt

   Pages 93-106

9. Plasminogen Activator Inhibitor Type-2 (PAI-2)/SerpinB2: A Unique Multifunctional Serpin

   • Tierra A. Johnson, Marguerite S. Buzza, Ekemini A. U. Riley, Toni M. Antalis

   Pages 107-126

10. Maspin Is a Multifunctional Tumor-Suppressing Serpin

    • Heidi Y. Shi, Jeremy S. Zhang, Ming Zhang

    Pages 127-152

11. Protein C Inhibitor

    • Felix C. Wahlmüller

    Pages 153-177

12. Protease Nexin-1: A Serpin Involved in Pathophysiology

    • Véronique Arocas, Marie-Christine Bouton

    Pages 179-196

13. PEDF in the Retina

    • Jeanee Bullock, S. Patricia Becerra

    Pages 197-212

14. Defining the Proteostasis Network Responsible for Managing the Fate of Newly Synthesized Alpha1-Antitrypsin

    • Richard N. Sifers

    Pages 213-228

15. Endoplasmic Reticulum Stress and the Protein Overload Response in the Serpinopathies

    • Adriana Ordóñez, Stefan J. Marciniak

    Pages 229-251

16. Serpins in Caenorhabditis elegans

    • Cliff J. Luke, Mark T. Miedel, Linda P. O’Reilly, Allyson Wyatt, Ryan R. Knoerdel, Stephen C. Pak et al.

    Pages 253-268

17. The Dual Role of Serpins and Tissue-Type Plasminogen Activator During Stroke

    • Benoit D. Roussel, Morgane Louessard, Sara Martinez de Lizarrondo, Denis Vivien

    Pages 269-292

18. Serpins, Viruses, and the Virome: New Directions in Therapy

    • Sriram Ambadapadi, Hao Chen, Donghang Zheng, Liying Liu, Erbin Dai, Ganesh Munuswamy-Ramanujam et al.

    Pages 293-326

19. Back Matter

    Pages 327-329

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The book provides an comprehensive overview on biology, genetics and cellular functions of serpins (serine protease inhibitors) in health and disease. With over 1000 members serpins are the most diverse family of protease inhibitors. Latest groundbreaking research findings are presented and broaden the understanding on inhibitory and non-inhibitory serpins, not only in mammalian organisms but also in insects, worms, plants and viruses.​

• Antitrypsin and Antithrombin
• Cellular Proteostasis Systems
• Proteolysis
• SERPINA and SERPINB
• Serine Protease Inhibitor

• Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Vienna, Austria

  Margarethe Geiger, Felix Wahlmüller, Margareta Furtmüller

Univ. Prof. Dr. Margarethe Geiger Department of Vascular Biology and Thrombosis Research, Center of Physiology and Pharmacology, Medical University of Vienna, Schwarzspanierstrasse 17, 1090 Wien Margarethe Geiger is a professor of vascular physiology at the Medical University of Vienna. Her research is focused on the role of non-inhibitory serine protease inhibitors in cell signaling. Dr. Margareta Furtmüller Department of Vascular Biology and Thrombosis Research, Med. Univ. Vienna, Schwarzspanierstrasse 17, 1090 Wien, email: margareta.furtmueller@meduniwien.ac.at Dr. Felix Wahlmüller Department of Vascular Biology and Thrombosis Research, Med. Univ. Vienna, Schwarzspanierstrasse 17, 1090 Wien, email: felix.wahlmueller@meduniwien.ac.at

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