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  • © 2015

Engineering Mineralized and Load Bearing Tissues

  • Provides a unique platform to achieve the coveted functional regeneration of mineralized and load bearing tissues
  • Represents a valuable reference source for university and college faculties, professionals, post-doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues
  • Covers 14 stimulating chapters, written by internationally recognized experts, and supported by informative tables and over 50 illustrations in color
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 881)

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Table of contents (14 chapters)

  1. Front Matter

    Pages i-x
  2. Fabrication Methods and Techniques

    1. Front Matter

      Pages 1-1
    2. 3D Printing and Biofabrication for Load Bearing Tissue Engineering

      • Claire G. Jeong, Anthony Atala
      Pages 3-14
    3. Microfabrication of Cell-Laden Hydrogels for Engineering Mineralized and Load Bearing Tissues

      • Chia-Cheng Li, Mahshid Kharaziha, Christine Min, Richard Maas, Mehdi Nikkhah
      Pages 15-31
    4. Electrospinning of Bioinspired Polymer Scaffolds

      • Jose V. Araujo, Pedro P. Carvalho, Serena M. Best
      Pages 33-53
  3. Applied Strategies for Tissue Engineering: Bone and Cartilage

    1. Front Matter

      Pages 55-55
    2. Bone Tissue Engineering Challenges in Oral & Maxillofacial Surgery

      • Brandon T. Smith, Jonathan Shum, Mark Wong, Antonios G. Mikos, Simon Young
      Pages 57-78
    3. Engineering Pre-vascularized Scaffolds for Bone Regeneration

      • Giada D. G. Barabaschi, Vijayan Manoharan, Qing Li, Luiz E. Bertassoni
      Pages 79-94
    4. Morphogenic Peptides in Regeneration of Load Bearing Tissues

      • Seyedsina Moeinzadeh, Esmaiel Jabbari
      Pages 95-110
    5. Osseointegration of Plateau Root Form Implants: Unique Healing Pathway Leading to Haversian-Like Long-Term Morphology

      • Paulo G. Coelho, Marcelo Suzuki, Charles Marin, Rodrigo Granato, Luis F. Gil, Nick Tovar et al.
      Pages 111-128
    6. Dentin Matrix Proteins in Bone Tissue Engineering

      • Sriram Ravindran, Anne George
      Pages 129-142
    7. Multiphasic, Multistructured and Hierarchical Strategies for Cartilage Regeneration

      • Clara R. Correia, Rui L. Reis, João F. Mano
      Pages 143-160
    8. Anterior Cruciate Ligament: Structure, Injuries and Regenerative Treatments

      • Ali Negahi Shirazi, Wojciech Chrzanowski, Ali Khademhosseini, Fariba Dehghani
      Pages 161-186
    9. Hard-Soft Tissue Interface Engineering

      • Oliver E. Armitage, Michelle L. Oyen
      Pages 187-204
  4. Applied Strategies for Tissue Engineering: Dentin, Enamel, Cementum and PDL

    1. Front Matter

      Pages 205-205
    2. Cementum and Periodontal Ligament Regeneration

      • Danijela Menicanin, K. Hynes, J. Han, S. Gronthos, P. M. Bartold
      Pages 207-236
    3. Amelogenin in Enamel Tissue Engineering

      • Vuk Uskoković
      Pages 237-254
    4. Whole Tooth Regeneration as a Future Dental Treatment

      • Masamitsu Oshima, Takashi Tsuji
      Pages 255-269
  5. Back Matter

    Pages 271-276

About this book

This book offers a comprehensive overview of current challenges and strategies to regenerate load-bearing and calcified human tissues, including bone, cartilage,tendon, ligaments and dental structures (dentin, enamel, cementum and periodontal ligament). Tissue engineering has long held great promises as an improved treatment option for conditions affecting mineralized and load-bearing structures in the body. Although significant progress has been achieved in recent years, a number of challenges still exist.

Scaffold vascularization, new biofabrication methods (3D printing, lithography, microfabrication), peptide conjugation methods, interface engineering, scaffold mechanical properties, iPS cells, organs-on-a-chip, are some of the topics discussed in this book. More specially, in the first section readers will find an overview of emerging biofabrication methods. In section 2, applied strategies for regeneration of (2.1) bone, cartilage and ligament, as well as (2.2) dentin, cementum, enamel and periodontal ligament are discussed across 14 chapters.

While other volumes have addressed the regeneration of individual tissues, or exclusively focused on different regenerative strategies, the focus of this work is to bring together researchers integrating backgrounds in materials sciences, engineering, biology, mechanics, fluidics, etc, to address specific challenges common to regeneration of several load-bearing and calcified tissues. Therefore, this book provides a unique platform to stimulate progress in the regeneration of functional tissue substitutes.

We envision that this book will represent a valuable reference source for university and college faculties, post‐doctoral research fellows, senior graduate students, and researchers from R&D laboratories in their endeavors to fabricate biomimetic load bearing tissues.

Editors and Affiliations

  • Center for Regenerative Medicine, Oregon Health and Science University, Portland, USA

    Luiz E. Bertassoni

  • Department of Biomaterials and Biomimetics, New York University, New York, USA

    Paulo G. Coelho

Bibliographic Information

  • Book Title: Engineering Mineralized and Load Bearing Tissues

  • Editors: Luiz E. Bertassoni, Paulo G. Coelho

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-22345-2

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015

  • Hardcover ISBN: 978-3-319-22344-5Published: 20 November 2015

  • Softcover ISBN: 978-3-319-35568-9Published: 23 August 2016

  • eBook ISBN: 978-3-319-22345-2Published: 07 November 2015

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: X, 276

  • Number of Illustrations: 6 b/w illustrations, 54 illustrations in colour

  • Topics: Systems Biology, Regenerative Medicine/Tissue Engineering, Dentistry

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access