Overview
- Nominated as an outstanding Ph.D. thesis by the University of Nottingham, UK
- Includes a concise review of electrocyclizations in natural product synthesis
- Presents a multidisciplinary approach to the investigation of natural products spanning chemistry, biology, and physics
- Describes the total synthesis of a number of complex polypropionate natural products, as well as a new methodology for accessing alkenyl halides
- Includes supplementary material: sn.pub/extras
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (7 chapters)
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Front Matter
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Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products
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Front Matter
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Synthesis of Alkenyl Nitriles by the Palladium-Catalysed Cyanation of Vinyl Halides with Acetone Cyanohydrin
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Front Matter
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Back Matter
Keywords
About this book
This thesis addresses fundamental scientific questions such as:
How are complex natural products synthesized in vivo?
Can we replicate these conditions in a laboratory environment?
What is the biological function of such secondary metabolites?
What are the biological origins of chirality?
These issues are explored in an accessible manner using a multidisciplinary approach spanning chemistry, biology and physics to investigate an interesting family of complex natural products isolated from marine molluscs – the tridachiahydropyrones.
The work has achieved:
Elegant biomimetic syntheses of a number of the tridachiahydropyrone compounds in vitro using organic synthesis techniques
The characterization of the interactions between these compounds and a range of model membrane systems using a series of fluorescence spectroscopic studies
The investigation of the antioxidant and photoprotective properties of the compounds by means of biophysical assay techniques
The synthesis of tridachiahydropyrone utilizing the model membrane systems as biomimetic reaction media.
Authors and Affiliations
Bibliographic Information
Book Title: Synthetic and Biophysical Studies on the Tridachiahydropyrone Family of Natural Products
Authors: Kimberley Jade Powell
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-22069-7
Publisher: Springer Cham
eBook Packages: Chemistry and Materials Science, Chemistry and Material Science (R0)
Copyright Information: Springer International Publishing Switzerland 2016
Hardcover ISBN: 978-3-319-22068-0Published: 22 August 2015
Softcover ISBN: 978-3-319-36981-5Published: 22 October 2016
eBook ISBN: 978-3-319-22069-7Published: 12 August 2015
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XIX, 136
Number of Illustrations: 134 b/w illustrations, 17 illustrations in colour
Topics: Organic Chemistry, Biological and Medical Physics, Biophysics, Spectroscopy/Spectrometry