Biology in Stem Cell Niche

1. Front Matter

   Pages i-xii

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2. The Hematopoietic Stem Cell Niche: Cell-Cell Interactions and Quiescence

   • Paul J. Childress, Marta B. Alvarez, Brahmananda R. Chitteti, Melissa A. Kacena, Edward F. Srour

   Pages 1-22

3. The Mammalian Limbal Stem Cell Niche: A Complex Interaction Between Cells, Growth Factors and Extracellular Matrix

   • Federico Castro-Muñozledo

   Pages 23-56

4. Emerging Engineering Strategies for Studying the Stem Cell Niche

   • Olivia J. Scheideler, Lydia L. Sohn, David V. Schaffer

   Pages 57-106

5. Bioreactors and the Design of the Stem Cell Niche

   • Yongjia Fan, Donghui Jing, Emmanuel S. Tzanakakis

   Pages 107-128

6. Stem Cell Niche-Radiobiological Response

   • David J. Olivos III, Rajendran Sellamuthu, Pratibha Singh, Sasidhar Vemula, Louis M. Pelus, Christie M. Orschell et al.

   Pages 129-146

7. Impact of Radiation on Hematopoietic Niche

   • Setsuko Mise-Omata, Takahiro S. Doi, Kazuhiro Aoki, Yuichi Obata

   Pages 147-160

8. From Neurogenic Niche to Site of Injury: Stem Cell-Mediated Biobridge for Brain Repair

   • Ike De La Pena, Naoki Tajiri, Sandra Acosta, Stephanny Reyes, Arum Yoo, Michael McGrogan et al.

   Pages 161-172

9. Using Stem Cells to Promote Wound Healing: An Emerging Solution for a Clinical Problem

   • Anthony D. Foster, Thomas A. Davis

   Pages 173-196

10. Cancer Stem Cell Niche

    • M. Mathonnet, A. Perraud, S. Blondy, N. Christou, H. Akil, S. Battu et al.

    Pages 197-209

11. Insight into Cancer Stem Cell Niche; Lessons from Cancer Stem Cell Models Generated In Vitro

    • Akifumi Mizutani, Ting Yan, Arun Vaidyanath, Junko Masuda, Akimasa Seno, Tomonari Kasai et al.

    Pages 211-226

12. Back Matter

    Pages 227-228

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This comprehensive volume explores functions, pathologies, and applications of stem cells in relation to the niches in which they develop. Ten chapters cover the subject in depth, from a historical perspective through signaling, hormonal control, quiescence, biomimetics, epigenetics, engineering strategies for emulating, tumorigenesis and more. The chapter authors represent a broad range of international expertise and perspectives.

This installment of the popular Stem Cell Biology and Regenerative Medicine series delivers authoritative, international perspectives on this rapidly growing field. Biology of Stem Cell Niche is an ideal complementary volume to Tissue-Specific Stem Cell Niche and Adult Stem Cells, Second Edition and will be invaluable to clinicians and researchers working with stem cells as well as to postgraduate trainees who are studying them.

• biomimetics
• cell signaling
• epigenetics
• quiescence
• tumorgenesis

• Sprott Centre for Stem Cell Research, Ottawa Hospital Research Institute, Ottawa, Canada

  Kursad Turksen

Kursad Turksen received his Ph.D. from the University of Toronto in the area of osteoprogenitor biology and cell selection methodologies. He then did postdoctoral training at the Howard Hughes Medical Institute, University of Chicago, studying epidermal biology through use of genetically-altered mouse models. He joined the Ottawa Hospital Research Institute [previously known as the Loeb Research Institute] where he rose to the position of Senior Scientist in the Division of Regenerative Medicine. His research interests focus on stem cell biology, with a particular interest in the Claudin family of tight junction proteins and their role in epidermal lineage commitment and progression during development in health and disease. Dr. Turksen is currently Editor in Chief of the Springer journal Stem Cell Reviews and Reports in addition to serving as series editor for the Springer series Stem Cell Biology and Regenerative Medicine.

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