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Antiepileptic Drugs and Pregnancy

A Guide for Prescribers

  • Book
  • © 2016

Overview

Authors:
  1. MJ Eadie

    1. Emeritus Professor of Clinical Neurology and Neuropharmacology, University of Queensland, and Honorary Consultant Neurologist, Royal Brisbane and Women's hospital, Brisbane, Australia

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  2. FJE Vajda

    1. Department of Medicine and Neurology, Director of the Australian Epilepsy and Pregnancy Register, University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia

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  • Provides a rational basis for treatment decisions involving antiepileptic drug use during pregnancy and in those wishing to become pregnant
  • Offers an up-to-date, systematic account of the teratogenic potential of anti-seizure drugs and weighs potential fetal adverse reactions against the risks of uncontrolled maternal seizure disorders
  • Describes the impact of pregnancy on the pharmacology of antiepileptic drugs
  • Includes supplementary material: sn.pub/extras

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Table of contents (12 chapters)

  1. Front Matter

    Pages i-xii
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  2. Introduction

    • MJ Eadie, FJE Vajda
    Pages 1-4

  3. Antiepileptic Drugs and Becoming Pregnant

    • MJ Eadie, FJE Vajda
    Pages 5-13

  4. Antiepileptic Drug Pharmacokinetics in Pregnancy

    1. Front Matter

      Pages 15-15
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    2. Antiepileptic Drug Disposition in Pregnancy

      • MJ Eadie, FJE Vajda
      Pages 17-26

    3. The Older Antiepileptic Drugs

      • MJ Eadie, FJE Vajda
      Pages 27-66

    4. Commonly Used Newer Antiepileptic Drugs

      • MJ Eadie, FJE Vajda
      Pages 67-85

    5. Antiepileptic Drugs Sometimes Used in Pregnancy

      • MJ Eadie, FJE Vajda
      Pages 87-108

  5. Antiepileptic Drugs and the Foetus

    1. Front Matter

      Pages 109-109
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    2. Antiepileptic Drugs, Epileptic Seizures and the Foetus

      • MJ Eadie, FJE Vajda
      Pages 111-127

    3. Antiepileptic Drugs and Foetal Malformations: A Possible Class Effect

      • MJ Eadie, FJE Vajda
      Pages 129-151

    4. Particular Antiepileptic Drugs and Foetal Malformations

      • MJ Eadie, FJE Vajda
      Pages 153-174

    5. Antiepileptic Drugs, Cognition and Neurodevelopment

      • MJ Eadie, FJE Vajda
      Pages 175-189

  6. Antiepileptic Drug Use and Pregnancy

    1. Front Matter

      Pages 191-191
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    2. Antiepileptic Drug Therapy: Management Issues and Pregnancy

      • MJ Eadie, FJE Vajda
      Pages 193-213

    3. Antiepileptic Drugs and Pregnancy: The Future

      • MJ Eadie, FJE Vajda
      Pages 215-220

  7. Back Matter

    Pages 221-232
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Keywords

About this book

A description of our current understanding of antiepileptic drug use during pregnancy, this book includes chapters on the impact of seizures on the mother and developing child, changes in maternal physiology during pregnancy and its impact on drug disposition, and the pharmacokinetic differences between the various anti-seizure medications. It also deals with the possible harmful effects of antiepileptic drug exposure during pregnancy on the physical and intellectual development of the fetus. Clinicians have to balance the potential adverse effects of the medicine for the fetus and mother-to-be against the risks that uncontrolled seizures hold for both when treating pregnant women with antiepileptic drugs. Only recently have enough scientific data emerged to provide a rational basis for treatment decisions that take in both aspects. This work provides a single, accessible and up-to-date resource for busy clinicians.

Authors and Affiliations

  • Emeritus Professor of Clinical Neurology and Neuropharmacology, University of Queensland, and Honorary Consultant Neurologist, Royal Brisbane and Women's hospital, Brisbane, Australia

    MJ Eadie

  • Department of Medicine and Neurology, Director of the Australian Epilepsy and Pregnancy Register, University of Melbourne and Royal Melbourne Hospital, Melbourne, Australia

    FJE Vajda

About the authors

Frank JE Vajda was trained in Melbourne and London.  He is Past President of the Epilepsy Society of Australia, Founder of the Raoul Wallenberg Centre for Clinical Neuropharmacology,Founder and Director of the AustralianPregnancy Register, Member of the Central Project Commission of EURAP and Professorial Fellow, Royal Melbourne Hospital, University of Melbourne. Previously, he was Professor of Clinical Neuropharmacology at Monash University.

Mervyn Eadie is currently Emeritus Professor of Clinical Neurology and Neuropharmacology in the University of Queensland and Honorary Consultant Neurologist to the Royal Brisbane and Women’s Hospital. He was formerly Chairman of the Australian Drug Evaluation Committee. His main research interests in recent years have been in the clinical pharmacology of drugs used for treating neurological disease and in the histories of epilepsy and migraine.

Bibliographic Information

  • Book Title: Antiepileptic Drugs and Pregnancy

  • Book Subtitle: A Guide for Prescribers

  • Authors: MJ Eadie, FJE Vajda

  • DOI: https://doi.org/10.1007/978-3-319-21434-4

  • Publisher: Adis Cham

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer International Publishing Switzerland 2016

  • Hardcover ISBN: 978-3-319-21433-7Published: 11 September 2015

  • Softcover ISBN: 978-3-319-36420-9Published: 23 August 2016

  • eBook ISBN: 978-3-319-21434-4Published: 27 August 2015

  • Edition Number: 1

  • Number of Pages: XII, 232

  • Topics: General Practice / Family Medicine, Obstetrics/Perinatology/Midwifery, Maternal and Child Health, Neurology

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