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Stem Cells in the Lung

Development, Repair and Regeneration

  • Book
  • © 2015

Overview

Editors:
  1. Ivan Bertoncello

    1. Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Australia

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  • Presents a comprehensive overview of the current understanding of the organization of endogenous lung stem and progenitor cell compartments from fetal development, postnatal growth and in adulthood
  • Scope is deliberately focused on taking a cellular perspective, rather than the molecular perspective covered elsewhere
  • Excludes any discussion of lung cancer so topic is covered in depth and does not overlap within the literature
  • Includes supplementary material: sn.pub/extras

Part of the book series: Stem Cell Biology and Regenerative Medicine (STEMCELL)

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xiv
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  2. Fetal Lung Development

    1. Front Matter

      Pages 1-1
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    2. The Regulation of Branching Morphogenesis in the Developing Lung

      • Jichao Chen
      Pages 3-16

    3. Epithelial–Mesenchymal Crosstalk in Lung Development

      • David Warburton
      Pages 17-23

    4. Lung Vasculogenesis and Angiogenesis

      • Bernard Thébaud, Mervin C. Yoder
      Pages 25-41

    5. Neural Regulation of Lung Development

      • Alan J. Burns, Lucy J. Freem, Jean-Marie Delalande
      Pages 43-62

    6. Fetal and Neonatal Origins of Lung Disease

      • Foula Sozo, Megan O’Reilly, Richard Harding
      Pages 63-94

  3. Adult Lung Stem and Progenitor Cells

    1. Front Matter

      Pages 95-95
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    2. Stem and Progenitor Cells of the Trachea and Proximal Airways

      • Ahmed E. Hegab, Tomoko Betsuyaku, Brigitte N. Gomperts
      Pages 97-112

    3. Stem Cells of the Distal Bronchiolar Airways

      • Robert E. Hynds, Adam Giangreco
      Pages 113-126

    4. Regenerative Cells in the Ageing Lung

      • Andrew M. Hoffman
      Pages 127-145

  4. Regulation of Lung Regeneration and Repair

    1. Front Matter

      Pages 147-147
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    2. Stromal Regulation of Lung Regeneration and Repair

      • Jonathan L. McQualter
      Pages 149-158

    3. Immunomodulatory Regulation of Lung Regeneration and Repair

      • Jonathan L. McQualter, Desiree Anthony, Ross Vlahos, Steven Bozinovski
      Pages 159-168

    4. Extracellular Matrix Specification of Regenerative Cells in the Adult Lung

      • Janette K. Burgess, Gavin Tjin
      Pages 169-189

    5. Role of Mechanical Stress in Lung Repair and Regeneration

      • Connie C. W. Hsia, Priya Ravikumar
      Pages 191-210

  5. Cellular Therapies for Lung Disease

    1. Front Matter

      Pages 211-211
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    2. Cellular Origins of Fibrotic Lung Diseases

      • Vibha N. Lama
      Pages 213-223

    3. Mesenchymal Stromal Cell-Based Therapies for Lung Disease

      • Daniel Chambers
      Pages 225-242

    4. Lung Vascular Regeneration and Repair

      • Mervin C. Yoder, Bernard Thébaud
      Pages 243-263
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Keywords

About this book

This book presents a comprehensive overview of the current understanding of the organization of endogenous lung stem and progenitor cell compartments during fetal lung development, postnatal lung growth and in adulthood. Progressing stage by stage, the chapters on fetal lung development emphasize the integrated role of epithelial, stromal, vascular and neural cell elements in building a functional lung, while the subsequent chapters on adult lung regeneration describe the nature and properties of adult lung stem/progenitor cells distributed along the proximal-distal axis of the airway tree. The chapters on regulation of lung regeneration and repair discuss how regenerative cells interact with their niche microenvironment and how regulation of lung regeneration and repair in the steady state and following injury recapitulates ontogeny. And, lastly, the chapters on cellular therapies for lung disease and bioengineering the lung focus on promising emerging therapies and approaches in lung regenerative medicine. The scope of this volume of the Stem Cell Biology and Regenerative Medicine series focuses on exploring the topic of building and rebuilding the lung from a cellular rather than a molecular perspective. Thus, the section on cellular therapies does not include extensive coverage of each of the numerous lung diseases, including cancer, which could be amenable to stem cell-based therapies, although the final chapter does include some discussion on the future prospects and challenges. All of the contributors are working on the cutting edge of the lung stem cell field, making this book essential reading for those with an interest in the field of lung stem cell biology and the potential role of cellular therapies and tissue bioengineering approaches in lung regenerative medicine, including biomedical scientists, graduate students, post-graduate researchers and respiratory clinicians.

Editors and Affiliations

  • Lung Health Research Centre, Department of Pharmacology and Therapeutics, University of Melbourne, Melbourne, Australia

    Ivan Bertoncello

About the editor

Ivan Bertoncello, MSc, PhD is an Honorary Principle Research Fellow and Associate Professor in the Department of Pharmacology and Therapeutics; and a member of the executive of the Lung Health Research Centre, at the University of Melbourne, Victoria, Australia. He has previously held appointments as Head of the Adult Lung Stem Cell Laboratory at the Australian Stem Cell Centre at Monash University; and Head of the Lung Regeneration Laboratory in the Department of Pharmacology and Therapeutics at the University of Melbourne. His international reputation in stem cell research was originally built on pioneering studies analysing the organisation and regulation of bone marrow stem and progenitor cells. His laboratory employed similar methods to analyse endogenous adult lung stem and progenitor cells in order to understand how regenerative cells in the adult lung are organised, and how they can be harnessed to treat lung disease or repair the injured lung.

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