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Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

  • Book
  • © 2015

Overview

Editors:
  1. Sadegh Babashah

    1. Faculty of Biol. Scs. Dept. of Mol. Gen., Tarbiat Modares University , Tehran, Iran

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  • Introduces emerging concepts in cancer stem cell biology and advances our understanding of potential cancer stem cell-based approaches for the development of therapeutic strategies in oncology
  • Provides a platform for cancer researchers to obtain new perspectives and insightful information regarding the potential role of cancer stem cells in the future of clinical oncology
  • Differing from other books on the topic, this book is a tremendous resource for both academic and clinical investigators

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Table of contents (19 chapters)

  1. Front Matter

    Pages i-xxx
    Download chapter PDF

  2. The Biology of Cancer Stem Cells

    1. Front Matter

      Pages 1-1
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    2. Cancer Stem Cells: A Quick Walk Through the Concepts

      • Katayoon Pakravan, Mohammad Amin Mahjoub, Babak Jahangiri, Sadegh Babashah
      Pages 3-11

    3. Cellular Plasticity, Cancer Stem Cells and Metastasis

      • Paola Ferrari, Andrea Nicolini
      Pages 13-66

    4. Cytokine Networks and Cancer Stem Cells

      • Clifford Liongue, Alister C. Ward, Wei Duan, Sarah Shigdar
      Pages 67-87

    5. Implications of CXCR4/CXCL12 Interaction for Cancer Stem Cell Maintenance and Cancer Progression

      • Claudia Peitzsch, Monica Cojoc, Ina Kurth, Anna Dubrovska
      Pages 89-130

    6. Non-coding RNAs in Cancer and Cancer Stem Cells

      • Ryou-u Takahashi, Hiroaki Miyazaki, Takahiro Ochiya
      Pages 131-153

    7. Self-Renewal Pathways in Mammary Stem Cells and Carcinogenesis

      • Lu Deng, Jiahui Xu, Dong Wang, Suling Liu
      Pages 155-174

  3. Cancer Stem Cells in Human Malignancies

    1. Front Matter

      Pages 175-175
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    2. Breast Cancer Stem Cells

      • Giorgia G. Silveira, Joao Paulo Oliveira-Costa, Alfredo Ribeiro-Silva
      Pages 177-197

    3. Lung Cancer Stem Cells

      • Gavitt A. Woodard, David M. Jablons
      Pages 199-225

    4. Colorectal Cancer Stem Cells

      • Pratima Nangia-Makker, Yingjie Yu, Lulu Farhana, Kulsoom Ahmed, Adhip P. N. Majumdar
      Pages 227-245

    5. Pancreatic Cancer Stem Cells

      • Deepak Ray, Reyhaneh Khoshchehreh, Alexandra Aicher, Christopher Heeschen
      Pages 247-271

    6. Glioblastoma Cancer Stem Cells

      • Luca Persano, Alessandro Della Puppa, Elena Porcù, Francesca Maule, Giampietro Viola
      Pages 273-296

    7. Head and Neck Cancer Stem Cells

      • Chiara Bianchini, Andrea Ciorba
      Pages 297-305

    8. Leukemic and Lymphoid Stem Cells

      • Michael W. Becker, Kristen M. O’Dwyer
      Pages 307-332

    9. Leukemic Stem Cells in Acute Lymphoblastic Leukemia

      • Ugo Testa
      Pages 333-389

  4. Novel Approaches for Targeting Cancer Stem Cells

    1. Front Matter

      Pages 391-391
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    2. Targeting Key Stemness-Related Pathways in Human Cancers

      • Krysta M. Coyle, Margaret L. Thomas, Mohammad Sultan, Paola Marcato
      Pages 393-443

    3. Targeting Cancer Stem Cells and the Tumor Microenvironment

      • Alice Turdo, Matilde Todaro, Giorgio Stassi
      Pages 445-476
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Keywords

About this book

The concept of cancer stem cells has great clinical implications. This is due to the fact that small subpopulations of these cells have been identified in a variety of neoplastic conditions ranging from solid tumors to liquid malignancies. Although there are some huge gaps in our current understanding of the role played by cancer stem cells in cancer biology, a growing body of evidence provides strong support for the principal functions of these cells in tumorigenesis. This has represented the potential of cancer stem cells in the development of novel and innovative tools for the treatment of metastatic tumors. This book aims to offer a broad framework for obtaining insight into the state-of-the-art knowledge on cancer stem cell biology and highlight the therapeutic implications of these cells in the future of clinical oncology.

Editors and Affiliations

  • Faculty of Biol. Scs. Dept. of Mol. Gen., Tarbiat Modares University , Tehran, Iran

    Sadegh Babashah

Bibliographic Information

  • Book Title: Cancer Stem Cells: Emerging Concepts and Future Perspectives in Translational Oncology

  • Editors: Sadegh Babashah

  • DOI: https://doi.org/10.1007/978-3-319-21030-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-21029-2Published: 24 November 2015

  • Softcover ISBN: 978-3-319-36393-6Published: 23 August 2016

  • eBook ISBN: 978-3-319-21030-8Published: 12 November 2015

  • Edition Number: 1

  • Number of Pages: XXX, 560

  • Topics: Cancer Research, Oncology, Drug Resistance, Molecular Medicine, Human Genetics

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