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  • © 2015

Intestinal Tumorigenesis

Mechanisms of Development & Progression

  • Provides in-depth review of recent developments in the field of intestinal tumorigenesis

  • Covers the role of signaling pathways, epigenetics and stem cells

  • Gives latest targeted therapies for intestinal tumorigenesis

  • Includes supplementary material: sn.pub/extras

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Table of contents (13 chapters)

  1. Front Matter

    Pages i-xi
  2. Hereditary CRC Syndromes

    • Manish Gala, Daniel C. Chung
    Pages 1-28
  3. Microsatellite Instability and Intestinal Tumorigenesis

    • Meena A. Prasad, Barbara Jung
    Pages 29-53
  4. Biology of Intestinal Epithelial Stem Cells

    • Noah F. Shroyer, Kristin Bell, Yuan-Hung Lo
    Pages 55-99
  5. The Role of PI3K Signaling Pathway in Intestinal Tumorigenesis

    • Jennifer W. Harris, Tianyan Gao, B. Mark Evers
    Pages 101-135
  6. The Epigenetics in Intestinal Tumorigenesis

    • Leticia Moreira, Francesc Balaguer, Ajay Goel
    Pages 137-168
  7. MicroRNA Involvement in Intestinal Tumorigenesis

    • Naohiro Nishida, George A. Calin
    Pages 169-188
  8. Microbiome Implications in Intestinal Tumorigenesis

    • David Posocco, Oxana Dmitrieva, Sergei I. Grivennikov
    Pages 189-209
  9. Inflammation and Colorectal Cancer

    • Rishu Dheer, Julie M. Davies, Maria T. Abreu
    Pages 211-256
  10. Sphingolipids in Intestinal Inflammation and Tumorigenesis

    • Mónica García-Barros, Nicolas Coant, Ashley J. Snider
    Pages 257-286
  11. Aging: An Etiological Factor in The Development of Intestinal Tumorigenesis

    • Jyoti Nautiyal, Krystyn Purvis, Adhip P. N. Majumdar
    Pages 287-308
  12. Epithelial to Mesenchymal Transition (EMT) and Intestinal Tumorigenesis

    • Ashleigh Pulkoski-Gross, Xi E. Zheng, Deborah Kim, Jillian Cathcart, Jian Cao
    Pages 309-364
  13. Omics and Biomarkers Development for Intestinal Tumorigenesis

    • Mehmet Koyuturk, Rod K. Nibbe
    Pages 365-389
  14. Targeted Therapies For Intestinal Tumorigenesis

    • E. Gabriela Chiorean, Andrew Coveler, Jon Grim, William M. Grady
    Pages 391-440
  15. Back Matter

    Pages 441-445

About this book

This volume includes the information necessary to understand recent critical advances in the mechanisms of intestinal tumorigenesis and to comprehend the complexity of the process. The volume aims to entice new researchers to participate in relevant studies, and to provide a forum for discussion within the scientific community to shape future research in this field. Discoveries in intestinal tumorigenesis lead to further understanding of mechanisms involved in colon cancer. Additionally, advancements in techniques and methods open the doors for new approaches to better define the molecular and organismal mechanisms of intestinal tumorigenesis. Chapters are authored by widely published authorities in the field.

Each year, there are close to 150,000 new cases of colorectal cancer, which results in approximately 50,000 deaths per year in the United States; these figures render colorectal cancer a significant health concern. Studies attempting to understand the mechanisms of development and progression of colorectal cancer have been ongoing for decades and each year brings new discoveries yielding a better comprehension of the underlying processes at work.

Editors and Affiliations

  • Department of Medicine, Stony Brook University, Stony Brook, USA

    Vincent W. Yang, Agnieszka B. Bialkowska

About the editors

Vincent W. Yang, MD, Ph.D, is a nationally recognized physician, scientist, and gastrointestinal cancer investigator. He is the Simons Chair of the Department of Medicine at Stony Brook University. He is also a Professor in the Department of Medicine, with a joint appointment as a Professor in the Department of Physiology & Biophysics. Dr. Yang is on the editorial board of such journals as the American Journal of Medicine, Translational Oncogenomics, World Journal of Gastroenterology, American Journal of Physiology-Gastrointestinal, and Liver Physiology. Throughout his career, Dr. Yang has received several awards and honors. He has published over 130 scientific papers and has been cited over 5,000 times.

 Agnieszka Bialkowska, Ph.D, is a Research Assistant Professor in the Department of Medicine at Stony Brook University. She specializes in the mechanisms of development and progression of colorectal cancer. Dr. Bialkowska is also a Senior Research Scientist in Dr. Vincent W. Yang's lab. She has published over 20 scientific papers.

Bibliographic Information

  • Book Title: Intestinal Tumorigenesis

  • Book Subtitle: Mechanisms of Development & Progression

  • Editors: Vincent W. Yang, Agnieszka B. Bialkowska

  • DOI: https://doi.org/10.1007/978-3-319-19986-3

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: Springer International Publishing Switzerland 2015

  • Hardcover ISBN: 978-3-319-19985-6Published: 02 October 2015

  • Softcover ISBN: 978-3-319-34624-3Published: 23 August 2016

  • eBook ISBN: 978-3-319-19986-3Published: 19 September 2015

  • Edition Number: 1

  • Number of Pages: XI, 445

  • Topics: Cancer Research, Molecular Medicine, Cell Biology

Buy it now

Buying options

eBook USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access