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The Smoothened Receptor in Cancer and Regenerative Medicine

  • Book
  • © 2015

Overview

Editors:
  1. Martial Ruat

    1. Institute of Neurosciences Paris-Saclay (Neuro-PSI), National Centre for Scientific Research, Gif-Yvette, France

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  • Overview chapters introduce the newcomer to the topic covered
  • Series covers hot topics of frontier research summarized by reputed scientists in the field
  • Volumes are useful and of relevance for a long period of time

Part of the book series: Topics in Medicinal Chemistry (TMC, volume 16)

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Table of contents (7 chapters)

  1. Front Matter

    Pages i-vii
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  2. Smoothened Inhibitors in Cancer

    • Martial Ruat, Lucile Hoch
    Pages 1-11

  3. Canonical and Non-Canonical Hedgehog Signaling Pathways: Role of G Proteins

    • Natalia A. Riobo
    Pages 13-42

  4. Structure–Activity Relationships and Mechanism of Action of Small Molecule Smoothened Modulators Discovered by High-Throughput Screening and Rational Design

    • Fabrizio Manetti, Maurizio Taddei, Elena Petricci
    Pages 43-107

  5. Receptor Modifications in Hedgehog Regulation

    • Qing Shi, Jin Jiang
    Pages 109-125

  6. Three-Dimensional Structure of the Smoothened Receptor: Implications for Drug Discovery

    • Didier Rognan, Isabelle Mus-Veteau
    Pages 127-146

  7. Smoothened, Stem Cell Maintenance and Brain Diseases

    • Martial Ruat, Hélène Faure, Mathieu Daynac
    Pages 147-171

  8. The Role of Smoothened and Hh Signaling in Neovascularization

    • Raffaella Soleti, Ramaroson Andriantsitohaina, Maria Carmen Martínez
    Pages 173-205

  9. Back Matter

    Pages 207-210
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Keywords

About this book

Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.

Editors and Affiliations

  • Institute of Neurosciences Paris-Saclay (Neuro-PSI), National Centre for Scientific Research, Gif-Yvette, France

    Martial Ruat

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