Animal Models of Ophthalmic Diseases

1. Front Matter

   Pages i-xv

   PDF

2. Animal Models of Herpes Keratitis

   • Robert L. Hendricks, Hongmin Yun, Alexander M. Rowe, Kate L. Carroll

   Pages 1-10

3. Animal Models of Cataracts

   • Judith West-Mays, Scott Bowman

   Pages 11-29

4. Animal Models of Glaucoma

   • Thomas V. Johnson, Stanislav I. Tomarev

   Pages 31-50

5. Animal Models of Age-Related Macular Degeneration: Subretinal Inflammation

   • Florian Sennlaub

   Pages 51-65

6. Animal Models of Diabetic Retinopathy

   • Mei Chen, Alan Stitt

   Pages 67-83

7. Animal Models of Autoimmune Uveitis

   • Jennifer L. Kielczewski, Rachel R. Caspi

   Pages 85-100

8. Animal Models of Retinitis Pigmentosa (RP)

   • Bo Chang

   Pages 101-116

9. An Animal Model of Graves’ Orbitopathy

   • J. Paul Banga, Sajad Moshkelgosha, Utta Berchner-Pfannschmidt, Anja Eckstein

   Pages 117-126

10. Animal Models of Ocular Tumors

    • Martine J. Jager, Jinfeng Cao, Hua Yang, Didier Decaudin, Helen Kalirai, Wietske van der Ent et al.

    Pages 127-140

11. Epilogue

    • Charles E. Egwuagu

    Pages 141-142

12. Back Matter

    Pages 143-152

    PDF

This book describes experimental animal models that mimic common human ocular diseases: herpetic keratitis, cataract, glaucoma, age-related macular degeneration, diabetic retinopathy, uveitis, retinitis pigmentosa, Graves’ disease, and intraocular tumors. In conjunction, these models reflect the diversity and utility of tools used to study human disease. World expert clinicians discuss each model based on their clinical experience and the text is supported by numerous photos and diagrams. In describing the most pertinent animal models of ophthalmic diseases, this book will be of interest to ophthalmologists, vision researchers, fellows, residents and medical students.

• Age-related Macular Degeneration
• Cataract
• Diabetic Retinopathy
• Glaucoma
• Intraocular Tumors

• Laboratory of Immunology, National Eye Institute, Bethesda, USA

  Chi-Chao Chan

Chi-Chao Chan, MD, graduated from the School of Medicine, Johns Hopkins University, Baltimore, Md., in 1975. She completed a residency in the Department of Ophthalmology, Stanford University School of Medicine and then became a Post-Doctoral Fellow at the Wilmer Ophthalmological Institute and a second Post-Doctoral Fellow at the National Eye Institute. Since 1992 she has been Chief of the Section on Immunopathology, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Md., and in 1999 she was also appointed Chief of the Histology Core at the institute. Dr. Chan has received numerous awards, including an American Academy of Ophthalmology Senior Achievement Award in 2013 and in 2011 she was named an ARVO (Association for Research in Vision Ophthalmology) Gold Fellow. Since 1998 she has been the Honorary Director of the Eye Research Institute, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China. Between 2007 and 2012 she was an Adjunct Professor in the Department of Ophthalmology & Visual Sciences, Chinese University of Hong Kong, and from 2008 to 2011, a Visiting Professor at Peking Union Medical College (PUMC), Beijing, China. Dr. Chan is an active member of many societies in the field of ophthalmology. She is an editorial board member for many journals, including the Journal of Ophthalmology, Journal of Ophthalmic Inflammation & Infection and the Journal of Clinical & Experimental Ophthalmology and from 2007 to 2014 was a Section Editor for the British Journal of Ophthalmology. She is the lead or co-author of more than 600 articles in peer-reviewed journals and co-author of Primary Intraocular Lymphoma (World Scientific Publishing Co., 2007).

Policies and ethics