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Immune Responses to Biosurfaces

Mechanisms and Therapeutic Interventions

  • Conference proceedings
  • © 2015

Overview

Editors:
  1. John D. Lambris

    1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

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  2. Kristina N. Ekdahl

    1. Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

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  3. Daniel Ricklin

    1. Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

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  4. Bo Nilsson

    1. Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

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  • Proceedings of the September 2014 Aegean Conference on Immune Responses to Bio surfaces
  • Discusses the immune response to biomaterial devices, implants and therapies that can adversely affect clinical outcomes
  • Features advances in biomaterial and cell surface treatments
  • Includes supplementary material: sn.pub/extras

Part of the book series: Advances in Experimental Medicine and Biology (AEMB, volume 865)

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Table of contents (13 papers)

  1. Front Matter

    Pages i-xii
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  2. Mechanisms

    1. Front Matter

      Pages 1-1
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    2. Thromboinflammation in Therapeutic Medicine

      • Kristina N. Ekdahl, Yuji Teramura, Sana Asif, Nina Jonsson, Peetra U. Magnusson, Bo Nilsson
      Pages 3-17

    3. Complement Interactions with Blood Cells, Endothelial Cells and Microvesicles in Thrombotic and Inflammatory Conditions

      • Diana Karpman, Anne-lie StÃ¥hl, Ida Arvidsson, Karl Johansson, Sebastian Loos, Ramesh Tati et al.
      Pages 19-42

    4. Role of Complement on Broken Surfaces After Trauma

      • Markus Huber-Lang, Anita Ignatius, Rolf E. Brenner
      Pages 43-55

    5. Complement Involvement in Periodontitis: Molecular Mechanisms and Rational Therapeutic Approaches

      • George Hajishengallis, Tomoki Maekawa, Toshiharu Abe, Evlambia Hajishengallis, John D. Lambris
      Pages 57-74

  3. Biomaterials

    1. Front Matter

      Pages 75-75
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    2. The Lectin Pathway of Complement and Biocompatibility

      • Estrid Hein, Peter Garred
      Pages 77-92

    3. Foreign Body Reaction to Subcutaneous Implants

      • Michail Kastellorizios, Namita Tipnis, Diane J. Burgess
      Pages 93-108

    4. Molecular Characterization of Macrophage-Biomaterial Interactions

      • Laura Beth Moore, Themis R. Kyriakides
      Pages 109-122

    5. Heparan Sulfate Proteoglycan Metabolism and the Fate of Grafted Tissues

      • Jeffrey L. Platt, Lucile E. Wrenshall, Geoffrey B. Johnson, Marilia Cascalho
      Pages 123-140

  4. Transplantation

    1. Front Matter

      Pages 141-141
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    2. Xenotransplantation of Cells, Tissues, Organs and the German Research Foundation Transregio Collaborative Research Centre 127

      • Bruno Reichart, Sonja Guethoff, Paolo Brenner, Thomas Poettinger, Eckhard Wolf, Barbara Ludwig et al.
      Pages 143-155

    3. Macroencapsulated Pig Islets Correct Induced Diabetes in Primates up to 6 Months

      • Pierre Gianello
      Pages 157-170

    4. Regulation of Instant Blood Mediated Inflammatory Reaction (IBMIR) in Pancreatic Islet Xeno-Transplantation: Points for Therapeutic Interventions

      • Ioannis Kourtzelis, Peetra U. Magnusson, Klara Kotlabova, John D. Lambris, Triantafyllos Chavakis
      Pages 171-188

    5. Cell Surface Engineering for Regulation of Immune Reactions in Cell Therapy

      • Yuji Teramura, Sana Asif, Kristina N. Ekdahl, Bo Nilsson
      Pages 189-209

    6. Complement Interception Across Humoral Incompatibility in Solid Organ Transplantation: A Clinical Perspective

      • Ali-Reza Biglarnia, Kristina N. Ekdahl, Bo Nilsson
      Pages 211-233

  5. Back Matter

    Pages 235-242
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Keywords

About this book

​The collection of chapters in this proceedings volume brings together research from academic and industry scientists and clinical development experts who are focused on contemporary and emerging aspects of improving treatments employing biosurfaces. Interactions between biomaterial implants, devices, cell therapies, and whole organ transplants frequently trigger activation of body defense systems and responses that negatively affect the clinical outcome. Optimal tissue integration and modulation of foreign body reactions is therefore essential for preserving anticipated functions and avoiding adverse effects. Topics covered include mechanistic and applied research within the fields of extracorporeal devices, soft and hard tissue implants, tissue and biomaterial-targeting, therapeutic modulation of foreign body reactions, cell encapsulations, as well as cell and whole organ transplantation.

Editors and Affiliations

  • Perelman School of Medicine, University of Pennsylvania, Philadelphia, USA

    John D. Lambris, Daniel Ricklin

  • Immunology, Genetics and Pathology, University of Uppsala, Uppsala, Sweden

    Kristina N. Ekdahl, Bo Nilsson

Bibliographic Information

  • Book Title: Immune Responses to Biosurfaces

  • Book Subtitle: Mechanisms and Therapeutic Interventions

  • Editors: John D. Lambris, Kristina N. Ekdahl, Daniel Ricklin, Bo Nilsson

  • Series Title: Advances in Experimental Medicine and Biology

  • DOI: https://doi.org/10.1007/978-3-319-18603-0

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015

  • Hardcover ISBN: 978-3-319-18602-3Published: 08 September 2015

  • Softcover ISBN: 978-3-319-37277-8Published: 22 October 2016

  • eBook ISBN: 978-3-319-18603-0Published: 25 August 2015

  • Series ISSN: 0065-2598

  • Series E-ISSN: 2214-8019

  • Edition Number: 1

  • Number of Pages: XII, 242

  • Number of Illustrations: 6 b/w illustrations, 28 illustrations in colour

  • Topics: Immunology, Biotechnology, Biomedical Engineering and Bioengineering

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