Skip to main content
SpringerLink
Log in

Life Extension

Lessons from Drosophila

  • Book
  • © 2015

Overview

Editors:
  1. Alexander M. Vaiserman

    1. Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  2. Alexey A. Moskalev

    1. Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  3. Elena G. Pasyukova

    1. Laboratory of Genome Variation, Institute of Molecular Genetics of RAS, Moscow, Russia

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

  • Collates world-leading research in the field of bio gerontology
  • Explores aging themes including health span and life extension, through Drosophila models
  • Expands understanding of longevity-associated genes and other mechanisms relating to aging
  • Includes supplementary material: sn.pub/extras

Part of the book series: Healthy Ageing and Longevity (HAL, volume 3)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book USD 109.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (16 chapters)

  1. Front Matter

    Pages i-viii
    Download chapter PDF

  2. Genetic Regulation of Longevity

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Neuronal Genes and Developmental Neuronal Pathways in Drosophila Life Span Control

      • Elena Pasyukova, Alexander Symonenko, Natalia Roshina, Mikhail Trostnikov, Ekaterina Veselkina, Olga Rybina
      Pages 3-37

    3. Gadd45 Proteins in Aging and Longevity of Mammals and Drosophila

      • Alexey A. Moskalev, Ekaterina N. Proshkina, Mikhail V. Shaposhnikov
      Pages 39-65

    4. Superoxide Dismutase (SOD) Genes and Aging in Drosophila

      • John Tower
      Pages 67-81

    5. Effect of Wolbachia Infection on Aging and Longevity-Associated Genes in Drosophila

      • Oleksandr M. Maistrenko, Svitlana V. Serga, Alexander M. Vaiserman, Iryna A. Kozeretska
      Pages 83-104

  3. Drosophila Models for Aging-Associated Diseases

    1. Front Matter

      Pages 105-105
      Download chapter PDF

  4. Drosophila Models for Aging-Associated Diseases

    1. Skeletal Muscle Homeostasis and Aging in Drosophila

      • Melissa J. Puppa, Fabio Demontis
      Pages 107-126

    2. Drosophila Models of Cardiac Aging and Disease

      • Alyson Sujkowski, Robert Wessells
      Pages 127-150

    3. Parallels Between Mammals and Flies in Inflammatory Bowel Disease

      • Christofi Theodoulakis, Yiorgos Apidianakis
      Pages 151-189

    4. Protein Quality Control in Brain Aging: Lessons from Protein Misfolding Disorders in Drosophila

      • Lorena de Mena, Pedro Fernandez-Funez, Diego E. Rincon-Limas
      Pages 191-211

    5. Drosophila Models in Therapeutic Drug Discovery Related to Aging

      • Charles D. Nichols
      Pages 213-225

  5. Life-Extending Treatments

    1. Front Matter

      Pages 227-227
      Download chapter PDF

    2. Life-Extending Effect of Phytochemicals in Drosophila

      • Lee Shin-Hae, Min Kyung-Jin
      Pages 229-244

    3. Life Extension in Drosophila by Histone Deacetylase Inhibitors

      • Alexander M. Vaiserman, Elena G. Pasyukova
      Pages 245-264

    4. An Evolutionary Analysis of Healthspan Extension Using Diet: Have We Come to the End of the Ponce de Leon Trail?

      • Grant A. Rutledge, Michael R. Rose
      Pages 265-283

    5. Atmosphere, Metabolism and Longevity

      • Khatchik Muradian
      Pages 285-299

    6. Effects of Mild Stresses Applied in Adults on Aging and Longevity

      • Éric Le Bourg
      Pages 301-320

    7. Strategies for Stage-Specific Extension of Longevity

      • Robert Arking
      Pages 321-347

  6. Erratum to: Parallels Between Mammals and Flies in Inflammatory Bowel Disease

    • Theodoulakis Christofi
    Pages E1-E1
Back to top

Keywords

About this book

​This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans.

Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine.

This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.

Editors and Affiliations

  • Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine

    Alexander M. Vaiserman

  • Laboratory of Molecular Radiobiology and Gerontology, Institute of Biology of Komi Science Center of Ural Branch of RAS, Syktyvkar, Russia

    Alexey A. Moskalev

  • Laboratory of Genome Variation, Institute of Molecular Genetics of RAS, Moscow, Russia

    Elena G. Pasyukova

Bibliographic Information

  • Book Title: Life Extension

  • Book Subtitle: Lessons from Drosophila

  • Editors: Alexander M. Vaiserman, Alexey A. Moskalev, Elena G. Pasyukova

  • Series Title: Healthy Ageing and Longevity

  • DOI: https://doi.org/10.1007/978-3-319-18326-8

  • Publisher: Springer Cham

  • eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)

  • Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2015

  • Hardcover ISBN: 978-3-319-18325-1Published: 25 June 2015

  • Softcover ISBN: 978-3-319-38210-4Published: 17 October 2016

  • eBook ISBN: 978-3-319-18326-8Published: 09 June 2015

  • Series ISSN: 2199-9007

  • Series E-ISSN: 2199-9015

  • Edition Number: 1

  • Number of Pages: VIII, 353

  • Number of Illustrations: 23 b/w illustrations, 26 illustrations in colour

  • Topics: Biomedicine general, Animal Genetics and Genomics, Geriatrics/Gerontology

Publish with us

Policies and ethics

Back to top

Search

Navigation