Authors:
- Nominated as an outstanding Ph.D. thesis by Columbia University, New York, USA
- Insightful and in-depth evaluation of the evidence for K63-linked regulatory ubiquitination in regulating cell-signalling in vitro
- First theses to directly test the role of regulatory ubiquitination in NF-kB signaling in vivo
- Reports the generation of a knock-in mouse that expresses a mutated form of A20 selectively lacking the deubiquitinase activity
- Critically determines the role of the deubiquitinase function of A20 in limiting inflammatory responses in vivo
Part of the book series: Springer Theses (Springer Theses)
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Table of contents (4 chapters)
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Front Matter
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Back Matter
About this book
Dr. Arnab De received his PhD from the Department of Microbiology & Immunology at Columbia University. During his PhD, he developed transgenic mice to study the mechanism of action of a critical tumor-suppressor called A20. He is also well known for having developed peptide-based prodrugs as therapeutics for diabetes. His work has been reported by the media, and has resulted in multiple patents and publications in peer reviewed journals. He presented his findings at the American Peptide Symposium and wasawarded the Young Investigator’s Award. He is the author of the book entitled Application of Peptide-Based Prodrug Chemistry in Drug Development, with a foreword written by Professor Jean Martinez (Former President, European Peptide Society) and published in the series SpringerBriefs in Pharmaceutical Science & Drug Development. His research interests lie at the intersection of chemistry and medicine. Besides biomedical research, he is also generally interested in public health policy and general scientific outreach.
Authors and Affiliations
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Microbiology & Immunology Hammer Health Sciences Center 1308, Columbia University Medical Center, New York, USA
Arnab De
About the author
Bibliographic Information
Book Title: Ubiquitin Chains: Degradation and Beyond
Authors: Arnab De
Series Title: Springer Theses
DOI: https://doi.org/10.1007/978-3-319-14965-3
Publisher: Springer Cham
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: Springer International Publishing Switzerland 2015
Hardcover ISBN: 978-3-319-14964-6Published: 26 March 2015
Softcover ISBN: 978-3-319-38534-1Published: 09 October 2016
eBook ISBN: 978-3-319-14965-3Published: 10 March 2015
Series ISSN: 2190-5053
Series E-ISSN: 2190-5061
Edition Number: 1
Number of Pages: XV, 103
Number of Illustrations: 12 b/w illustrations, 33 illustrations in colour
Topics: Protein Science, Cell Cycle Analysis, Immunology