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Correlation Force Spectroscopy for Single Molecule Measurements

  • Book
  • © 2015

Overview

Authors:
  1. Milad Radiom

    1. Department of Chemical Engineering, Virginia Tech, Blacksburg, USA

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  • Nominated as an outstanding theses by Virginia Tech
  • Introduces the dynamic new technique for correlation force spectroscopy (CFS)
  • Details the significance of CFS in polymer physics and chemistry
  • Explains the measurement capability in the area of high frequency rheology and single molecule dynamic measurements
  • Includes supplementary material: sn.pub/extras

Part of the book series: Springer Theses (Springer Theses)

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Table of contents (9 chapters)

  1. Front Matter

    Pages i-xxvii
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  2. Introduction

    • Milad Radiom
    Pages 1-9

  3. Correlation Force Spectroscopy

    • Milad Radiom
    Pages 11-23

  4. Dynamics of Single Molecules

    • Milad Radiom
    Pages 25-38

  5. Microrheology with Correlation Force Spectroscopy

    • Milad Radiom
    Pages 39-45

  6. Development of Colloidal Probe Correlation Force Spectroscopy: Case Study

    • Milad Radiom
    Pages 47-62

  7. Correlation Force Spectroscopy for Single-Molecule Measurements

    • Milad Radiom
    Pages 63-69

  8. Single-Molecule Force Spectroscopy of Dextran

    • Milad Radiom
    Pages 71-81

  9. Single Molecule Force Spectroscopy of Single-Stranded DNA

    • Milad Radiom
    Pages 83-99

  10. Summary

    • Milad Radiom
    Pages 101-104

  11. Back Matter

    Pages 105-117
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Keywords

About this book

This thesis addresses the development of a new force spectroscopy tool, correlation force spectroscopy (CFS) for the measurement of the properties of very small volumes of material (molecular to µm3) at kHz-MHz frequency range. CFS measures the simultaneous thermal fluctuations of two closely-spaced atomic force microscopy (AFM) cantilevers.  CFS then calculates the cross-correlation in the thermal fluctuations that gives the mechanical properties of the matter that spans the gap of the two cantilevers. The book also discusses development of CFS, its advantages over AFM, and its application in single molecule force spectroscopy and micro-rheology.

Authors and Affiliations

  • Department of Chemical Engineering, Virginia Tech, Blacksburg, USA

    Milad Radiom

About the author

Milad Radiom received his PhD in Chemical Engineering at Virginia Tech in 2014, after MEng and BSc in Thermal and Fluids Engineering and Mechanical Engineering respectively from Nanyang Technological University and Amirkabir University of Technology. Thereafter, he was appointed as a postdoctoral research associate in Laboratory of Colloid and Surface Chemistry, University of Geneva.  His research interests are physical chemistry of polymers, colloids and surfaces as related to single molecule force spectroscopy, micro-rheology and surface forces.

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